PVP (Polyvinylpyrrolidone)

Burnett, Christina L.

doi:10.1177/1091581817716649

Cited by 16 publications

(11 citation statements)

References 19 publications

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“…PVP has a wide number of applications in cosmetics. It acts as a binder, film former, hair fixative, dispersing agent, surfactant, viscosity enhancer, and stabilizer in different cosmetic products [ 180 ]. Different cosmetic products that are prepared with PVP as an ingredient include shampoos, hair sprays, hair setting lotions, eye shadows, eyeliners, mascara, lipsticks, nail polishes, shaving creams, moisturizers, etc and its use in cosmetics is reported to be as safe [ 181 ].…”

Section: Pvp As An Excipient In the Formulation Of Cosmeticsmentioning

confidence: 99%

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Kurakula

Rao

2020

Journal of Drug Delivery Science and Technology

294

172

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Polyvinylpyrrolidone (PVP) is a water-soluble polymer obtained by polymerization of monomer N -vinylpyrrolidone. PVP is an inert, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps to encapsulate and cater both hydrophilic and lipophilic drugs. These advantages enable PVP a versatile excipient in the formulation development of broad conventional to novel controlled delivery systems. PVP has tunable properties and can be used as a brace component for gene delivery, orthopedic implants, and tissue engineering applications. Based on different molecular weights and modified forms, PVP can lead to exceptional beneficial features with varying chemical properties. Graft copolymerization and other techniques assist PVP to conjugate with poorly soluble drugs that can inflate bioavailability and even introduces the desired swelling tract for their control or sustained release. The present review provides chemistry, mechanical, physicochemical properties, evaluation parameters, dewy preparation methods of PVP derivatives intended for designing conventional to controlled systems for drug, gene, and cosmetic delivery. The past and growing interest in PVP establishes it as a promising polymer to enhance the trait and performance of current generation pharmaceutical dosage forms. Furthermore, the scrutiny explores existing patents, marketed products, new and futuristic approaches of PVP that have been identified and scope for future development, characterization, and its use. The exploration spotlights the importance and role of PVP in the design of Povidone-iodine (PVP–I) and clinical trials to assess therapeutic efficacy against the COVID-19 in the current pandemic scenario.

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Section: Pvp As An Excipient In the Formulation Of Cosmeticsmentioning

confidence: 99%

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Kurakula

Rao

2020

Journal of Drug Delivery Science and Technology

294

172

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“…The amount of PVP released into the culture medium over a certain period of time is determined by the content of PVP in the sample. It is known that PVP is protonated in aqueous solutions and can form complexes with anions, including various biologically active molecules [45]. Thus, an increase of PVP content may lead to an increase in the content of complexes with biologically active anions in the culture medium, changing its chemical composition and reducing the availability of anions for cells.…”

Section: Resultsmentioning

confidence: 99%

“…It might be due to following reasons. First, membranes made by electrospinning have interconnected porosity formed by micron-sized fibers, resulting in a significant free surface [47] and the ability of PVP to bind toxins and water [45]. These properties of the obtained membranes make it possible to absorb a significant amount of exudate released by pathogenic microflora, as well as maintaining the required moisture level on the wound surface.…”

Section: Resultsmentioning

confidence: 99%

Composite Ferroelectric Membranes Based on Vinylidene Fluoride-Tetrafluoroethylene Copolymer and Polyvinylpyrrolidone for Wound Healing

et al. 2020

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Wound healing is a complex process and an ongoing challenge for modern medicine. Herein, we present the results of study of structure and properties of ferroelectric composite polymer membranes for wound healing. Membranes were fabricated by electrospinning from a solution of vinylidene fluoride/tetrafluoroethylene copolymer (VDF–TeFE) and polyvinylpyrrolidone (PVP) in dimethylformamide (DMF). The effects of the PVP content on the viscosity and conductivity of the spinning solution, DMF concentration, chemical composition, crystal structure, and conformation of VDF–TeFE macromolecules in the fabricated materials were studied. It was found that as PVP amount increased, the viscosity and conductivity of the spinning solutions decreased, resulting in thinner fibers. Using FTIR and XRD methods, it was shown that if the PVP content was lower than 50 wt %, the VDF–TeFE copolymer adopted a flat zigzag conformation (TTT conformation) and crystalline phases with ferroelectric properties were formed. Gas chromatography results indicated that an increase in the PVP concentration led to a higher residual amount of DMF in the material, causing cytotoxic effects on 3T3L1 fibroblasts. In vivo studies demonstrated that compared to classical gauze dressings impregnated with a solution of an antibacterial agent, ferroelectric composite membranes with 15 wt % PVP provided better conditions for the healing of purulent wounds.

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“…The amount of PVP released into the culture medium over a certain period of time is determined by the content of PVP in the sample. It is known that PVP is protonated in aqueous solutions and can form complexes with anions, including various biologically active molecules [34]. Thus, an increase of PVP content may lead to an increase in the content of complexes with biologically active anions in the culture medium, changing its chemical composition and reducing the availability of anions for cells.…”

Section: Resultsmentioning

confidence: 99%

“…It might be due to following reasons. First, membranes made by electrospinning have interconnected porosity formed by micron-sized fibers resulting in significant free surface [36] and the ability of PVP to bind toxins and water [34]. These properties of the obtained membranes make it possible to absorb a significant amount of exudate released by pathogenic microflora, as well as maintain the required moisture level on the wound surface.…”

Section: Resultsmentioning

confidence: 99%

Composite Ferroelectric Membranes based on Vinylidene Fluoride-Tetrafluoroethylene Copolymer and Polyvinylpyrrolidone for Wound Healing: A Pilot Study

Tverdokhlebova¹,

Antipina²,

Kudryavtseva³

et al. 2020

Preprint

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Herein, we report results of the study of the composite ferroelectric scaffolds based on vinylidene fluoride-tetrafluoroethylene copolymer (VDF-TeFE) and polyvinylpyrrolidone (PVP) produced by electrospinning and their application as a wound-healing material. The physicochemical properties of ferroelectric composite polymer scaffolds depending on the content of PVP (in the range from 0 to 50 wt %) including morphology, composition and crystalline structure were studied. The cytotoxicity of materials and the proliferative activity of cells during their cultivation on the surface of formed scaffolds are reported. It has been found that the optimal PVP content in the VDF-TeFE composite scaffolds is 15 wt%. On a model of a full-thickness contaminated wound in vivo, it was shown that piezoelectric scaffolds based on VDF-TeFE copolymer containing 15 wt% PVP provide better wound healing results in comparison with standard gauze dressings impregnated with a solution of an antibacterial agent.

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PVP (Polyvinylpyrrolidone)

Cited by 16 publications

References 19 publications

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Composite Ferroelectric Membranes Based on Vinylidene Fluoride-Tetrafluoroethylene Copolymer and Polyvinylpyrrolidone for Wound Healing

Composite Ferroelectric Membranes based on Vinylidene Fluoride-Tetrafluoroethylene Copolymer and Polyvinylpyrrolidone for Wound Healing: A Pilot Study

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