[PVP‐SO₃H] HSO₄: An Efficient Polymeric Solid Acid Catalyst for the Formylation and N‐Boc Protection Reactions

Abstract

In the present work, the formylation of a variety of amines and alcohols was performed using [PVP‐SO3H] HSO4 as a powerful solid acid catalyst under solvent‐free conditions. Under this catalytic condition, N‐Boc protection of amines was also successfully done at room temperature. Easy and economical methodology, short reaction times, high yields, chemo‐selectivity, high TOF and easy workup are some of the advantages of this work. Furthermore, [PVP‐SO3H]HSO4 can be easily separated and reused for several times without considerable loss of its catalytic activity.

Efficient N-formylation of primary aromatic amines using novel solid acid magnetic nanocatalyst

“…Presumably, the mechanism of the reaction proceeds through activation of carbonyl group of formic acid in situ by the action of SO 3 H group of nanocatalyst. 47,48 In the rst step, the SO 3 H proton of the nanocatalyst interacts with the oxygen atom of the carbonyl group of the formic acid, thereby increasing the electrophilic character of the carbonyl carbon probably through hydrogen bond formation. Then, the lone pair of electron on the nitrogen atom of aniline attack the cationic carbon of formic acid.…”

Reductive N-Formylation of Nitroarenes Mediated by Rongalite

“…In organic synthesis, formamides are key building blocks for functionalizations to form privileged structures . Moreover, formamides play an important role in a variety of valuable substances such as pharmaceuticals, dyes, fragrances, and pesticides, as well as natural products and other bioactive molecules (Figure ). , Therefore, the exploration of methodologies for the synthesis of formamides represents a worthwhile pursuit in scientific research and industrial manufacture.…”