Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development

Schwab, Kristopher R.; Patterson, Larry T.; Hartman, Heather A.; Song, Ning; Lang, Richard A.; Lin, Xinhua; Potter, S. Steven

doi:10.1186/1741-7007-5-15

Cited by 89 publications

(103 citation statements)

References 39 publications

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“…Th ese similarities underscore the involvement of Wnt / β -catenin signalling in the regulation of Gcm1 expression and initiation of the branching morphogenesis in the placental labyrinth layer. In addition, as Pygo1 / Pygo2 doubledefi cient mice have been reported not to show any major placental phenotype 47 , the role of BCL9L in placental morphogenesis is independent of the Pygo family of genes. Th is fi nding is consistent with previous reports showing that Pygo is dispensable for the transactivation activity of the BCL9 family of genes 23,48 .…”

Section: Discussionmentioning

confidence: 97%

Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway

et al. 2011

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Cell fusion has a critical role in various developmental processes, immune response, tissue homeostasis and regeneration, and possibly, in cancer. However, the signals that regulate cell fusion remain poorly understood. In a screen for novel targets of Wnt / β -catenin signalling, we identifi ed glial cells missing 1 ( GCM1 ), which encodes a transcription factor that is involved in epigenetic regulation and is critical for the fusion of syncytiotrophoblast (ST) cells. Here we show that β -catenin / BCL9-Like (BCL9L) / T-cell factor 4 (TCF4) signalling directly targets the GCM1 / syncytin pathway and thereby regulates the fusion of human choriocarcinoma cells. Furthermore, we show that the GCM1 / syncytin-B pathway is signifi cantly downregulated in the placenta of BCL9L-defi cient mice and that the fusion and differentiation of ST-II cells are blocked. Our results demonstrate a signal transduction pathway that regulates cell fusion, and may provide intriguing perspectives into the various biological and pathological processes that involve cell fusion.

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Section: Discussionmentioning

confidence: 97%

Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway

et al. 2011

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“…However, even though Pygo's biochemical properties are conserved in mammalian Pygo1 and Pygo2 (Fiedler et al 2008;Kramps et al 2002), pygo1, pygo2 or double knockouts in mice have a surprisingly mild decrease in Wnt signaling (Li et al 2007a;Schwab et al 2007;Song et al 2007). Perhaps this is because mouse BCL9 contains its own transactivation domain (Sustmann et al 2008).…”

Section: Into the Nucleus-target Gene Regulation By Bcat/armmentioning

confidence: 99%

Wnt Signaling from Development to Disease: Insights from Model Systems

Cadigan¹,

Peifer²

2009

Cold Spring Harbor Perspectives in Biology

275

259

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One of the early surprises in the study of cell adhesion was the discovery that b-catenin plays dual roles, serving as an essential component of cadherin-based cell -cell adherens junctions and also serving as the key regulated effector of the Wnt signaling pathway. Here, we review our current model of Wnt signaling and discuss how recent work using model organisms has advanced our understanding of the roles Wnt signaling plays in both normal development and in disease. These data help flesh out the mechanisms of signaling from the membrane to the nucleus, revealing new protein players and providing novel information about known components of the pathway.

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“…In doing so, it may predispose these genes for Wingless-induced transcription, or oppose their terminal shut-down by transcriptional repressors after a Wingless signaling phase. Importantly, the observed bypass of Pygo function in Drosophila gro mutants could provide an explanation why Pygo proteins appear less critical for Wnt outputs in vertebrates compared with the fly (27)(28)(29)(30)(31): it is conceivable that vertebrate Wnt target genes are naturally derepressed and/or poised for transcriptional activity, so their Wnt inducibility depends to a lesser extent on the anti-repressor function of Pygo than in flies.…”

Section: Discussionmentioning

confidence: 99%

“…Vertebrates encode two Pygo orthologues, which contribute to efficient ␤-catenin-mediated transcription during development (27)(28)(29)(30)(31) and in cancer cell lines with high Wnt pathway activity (24,32), although their roles in Wnt signaling seem to be less critical than in flies. Pygo proteins are nuclear proteins that associate with Armadillo/␤-catenin via the adapter protein Legless (or BCL9), although their molecular function with regard to TCF-dependent transcription remains unclear.…”

mentioning

confidence: 99%

A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription

Mieszczanek

Bienz

2008

Proc. Natl. Acad. Sci. U.S.A.

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Wnt/␤-catenin signaling controls animal development and tissue homeostasis, and is also an important cancer pathway. Pygopus (Pygo) is a conserved nuclear Wnt signaling component that is essential for Wingless-induced transcription throughout Drosophila development. It associates with Armadillo/␤-catenin and T cell factor (TCF) through the Legless/BCL9 adaptor, but its molecular function in TCF-mediated transcription is unknown. Here, we use a groucho-null allele to show that Groucho represses Wingless target genes during Drosophila development. Interestingly, groucho pygo double-mutants revealed that Pygo is not obligatory for transcriptional and phenotypic Wingless signaling outputs if the interaction between Groucho and Drosophila TCF is compromised genetically. Pygo function is also non-essential for Wingless outputs in the absence of other transcriptional antagonists of Wingless signaling. This indicates an anti-repressor function of Pygo: we propose that Pygo predisposes Drosophila TCF target genes for rapid Wingless-induced transcription, or that it protects them against premature shut-down.ecdysone signaling ͉ Groucho ͉ transcriptional repression ͉ Wnt signaling

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Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development

Cited by 89 publications

References 39 publications

Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway

Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway

Wnt Signaling from Development to Disease: Insights from Model Systems

A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription

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