2009
DOI: 10.1083/jcb.200810133
|View full text |Cite
|
Sign up to set email alerts
|

Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation

Abstract: Recent studies have unequivocally identified multipotent stem/progenitor cells in mammary glands, offering a tractable model system to unravel genetic and epigenetic regulation of epithelial stem/progenitor cell development and homeostasis. In this study, we show that Pygo2, a member of an evolutionarily conserved family of plant homeo domain–containing proteins, is expressed in embryonic and postnatal mammary progenitor cells. Pygo2 deficiency, which is achieved by complete or epithelia-specific gene ablation… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

15
161
2

Year Published

2011
2011
2019
2019

Publication Types

Select...
5
3

Relationship

1
7

Authors

Journals

citations
Cited by 116 publications
(178 citation statements)
references
References 85 publications
15
161
2
Order By: Relevance
“…S2), we sought to use the K14-Cre mice to generate skin epithelia-specific Pygo2 knockout (SSKO: K14-Cre/Pygo2 floxed/-) to assess the importance of epithelially expressed Pygo2. Despite efficient Cre-mediated deletion (15), SSKO animals showed largely normal epidermal and HF morphogenesis (Fig. S3A).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…S2), we sought to use the K14-Cre mice to generate skin epithelia-specific Pygo2 knockout (SSKO: K14-Cre/Pygo2 floxed/-) to assess the importance of epithelially expressed Pygo2. Despite efficient Cre-mediated deletion (15), SSKO animals showed largely normal epidermal and HF morphogenesis (Fig. S3A).…”
Section: Resultsmentioning
confidence: 99%
“…Pygo proteins directly bind to an active transcriptional histone mark, lysine 4-trimethylated histone H3 (H3K4me3) (14,15). Furthermore, Pygo2 regulates the production of histone marks at target loci in part by recruiting histone-modifying enzymes (15)(16)(17)(18)(19)(20). Germ-line deletion of Pygo2 results in improper HF morphogenesis (21).…”
mentioning
confidence: 99%
“…In addition, the roles for transcriptional cofactors of b-catenin, BCL9/BCL9L and PYGO2, in adult stem cell proliferation have been associated with their function as readers of histone marks H3K4me2 and H3K4me3 (Fiedler et al, 2008;Chen et al, 2010). BCL9 and homolog BCL9L are necessary for adult stem cellmediated regeneration of muscle and colon epithelium (Brack et al, 2009;Deka et al, 2010), whereas PYGO2 promotes self-renewal of mammary progenitor cells through regulation of cell cycle progression (Gu et al, 2009;Chen et al, 2010). In mammary progenitors, PYGO2 binds to H3K4me2 and H3K4me3 and recruits histone methyltransferases to catalyze this active mark at WNT target genes (Gu et al, 2009;Chen et al, 2010).…”
Section: Foxo Transcription Factors In Adult Stem Cells: Integratingmentioning
confidence: 99%
“…BCL9 and homolog BCL9L are necessary for adult stem cellmediated regeneration of muscle and colon epithelium (Brack et al, 2009;Deka et al, 2010), whereas PYGO2 promotes self-renewal of mammary progenitor cells through regulation of cell cycle progression (Gu et al, 2009;Chen et al, 2010). In mammary progenitors, PYGO2 binds to H3K4me2 and H3K4me3 and recruits histone methyltransferases to catalyze this active mark at WNT target genes (Gu et al, 2009;Chen et al, 2010). In other adult stem cells, b-catenin complexes likely control active chromatin marks in response to WNT signaling.…”
Section: Foxo Transcription Factors In Adult Stem Cells: Integratingmentioning
confidence: 99%
“…Additionally, Pygo2 contains a PHD domain that recognizes histone H3K4me2/3, and this interaction is critical to mammary progenitor cell expansion. Pygo2 also facilitates the generation of these marks by physically interacting with Wdr5 at Wntspecific loci and in bulk chromatin, thereby creating a positive feedback loop for the establishment of active chromatin domains [38].…”
Section: Discussionmentioning
confidence: 99%