2021
DOI: 10.1016/j.prp.2021.153389
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Pyloric gland metaplasia: Potential histologic predictor of severe pouch disease including Crohn’s disease of the pouch in ulcerative colitis

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Cited by 6 publications
(3 citation statements)
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“…1 CD of the pouch has an estimated incidence of 10% to 20% in UC and indeterminate colitis following IPAA. 21 It remains debatable whether CD of the pouch is a part of the IBD spectrum or a phenotype distinct from classic CD and classic UC. Diagnosis of CD of the pouch is based on a combination of clinical, imaging, endoscopic, and histologic findings after excluding surgical complications.…”
Section: Crohn's Disease Of the Pouchmentioning
confidence: 99%
See 1 more Smart Citation
“…1 CD of the pouch has an estimated incidence of 10% to 20% in UC and indeterminate colitis following IPAA. 21 It remains debatable whether CD of the pouch is a part of the IBD spectrum or a phenotype distinct from classic CD and classic UC. Diagnosis of CD of the pouch is based on a combination of clinical, imaging, endoscopic, and histologic findings after excluding surgical complications.…”
Section: Crohn's Disease Of the Pouchmentioning
confidence: 99%
“…PGM is a common feature in CD of the pouch; however, it can also occur in pouchitis of comparable severity. 21 Likewise, the presence of transmural inflammation in excised pouch specimens is insufficient for diagnosing CD of the pouch because of low sensitivity (about 20%) and low specificity. 22 The combination of chronic mucosal injury and transmural lymphoid aggregates was seen in only 20% of surgically resected pouches with presumed CD of the pouch.…”
Section: Secondary Pouchitismentioning
confidence: 99%
“…In CD the presence of metaplastic changes such as pyloric gland metaplasia or gastric foveolar metaplasia have been described in the small bowel mucosa or in pouchitis in long-standing disease [17][18][19][20][21][22]. Recently, gastric metaplasia (GM) has been identified as a substrate for the initiation of the serrated pathway of CRC, due to the continuous lesion of the colonic epithelium of the right colon [23].…”
Section: Introductionmentioning
confidence: 99%