Pyoderma gangrenosum: a presenting sign of myelodysplastic syndrome in undiagnosed Fanconi anemia

Pyoderma Gangrenosum Revealing Myeloid Activation of Fanconi Anaemia: Two Case Reports

“…We describe here 2 adult patients with long-standing FA diagnoses who developed PG, revealing an acceleration of their myeloid disorder. To our knowledge only 2 similar cases have been reported previously ( 5 , 6 ).…”

“…ND has rarely been described in association with FA: 11 cases of Sweet’s syndrome and 2 cases of PG ( 5 , 6 , 8 ). In almost all cases, the onset of Sweet’s syndrome was associated with progression to malignant haematological disease.…”

“…One case of PG occurred after the underlying malignant disease had been diagnosed ( 5 ). The other case of PG led to the discovery of the underlying FA and its progression towards MDS ( 6 ).…”