Pyoderma gangrenosum in a newborn - case report

Carneiro, Francisca Regina Oliveira; Santos, Maria Amélia Lopes dos; Sousa, Brena Andrade de; Nascimento, Carla do Socorro Silva do; Amin, Gabriela Athayde; Moutinho, Ana Thaís Machado

doi:10.1590/abd1806-4841.20132601

Cited by 9 publications

(4 citation statements)

References 7 publications

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“…Pyoderma gangrenosum is neutrophilic dermatosis that is destructive in nature with unknown causes. More than half of patients with PG develop the disorder in association with an underlying systemic disease [11]. However, the diagnosis is made after excluding other causes of ulcerative skin lesions via histopathological findings.…”

Section: Discussionmentioning

confidence: 99%

Pyoderma gangrenosum with splenic involvement

AlDossary

AlFawaz

AlMutairi

2016

International Journal of Pediatrics and Adolescent Medicine

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Pyoderma gangrenosum (PG) is a non-infectious disease characterized by necrotizing, ulcerative, and painful skin. The incidence of PG is approximately 3–10 cases per million people per year. Pyoderma gangrenosum is rarely observed in children, which accounts for less than 4%, but it primarily affects adults between the ages of 25 and 54 years old without gender preference. Here, we present a case report of a 16-month-old toddler diagnosed with pyoderma gangrenous with splenic involvement. The young age of the patient and extracutaneous manifestation are of high interest.

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Section: Discussionmentioning

confidence: 99%

Pyoderma gangrenosum with splenic involvement

AlDossary

AlFawaz

AlMutairi

2016

International Journal of Pediatrics and Adolescent Medicine

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“…It is often associated with a concomitant disease, although up to half of cases are considered idiopathic . Infantile PG is even less common, with only 20 cases reported, 11 of which are described as idiopathic, whereas the others are associated with a spectrum of inflammatory, hematologic, and infectious disorders (Table ) . With this report, we add another patient with infantile PG and review the literature for potential treatments.…”

Section: Introductionmentioning

confidence: 97%

Pyoderma gangrenosum in an infant: A case report and review of the literature

Crouse

McShane

Morrell

et al. 2018

Pediatric Dermatology

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Pyoderma gangrenosum is a neutrophilic dermatosis that is rare in infancy, with only 20 cases reported in the literature. We present a case of infantile pyoderma gangrenosum refractory to topical steroids, tacrolimus, and dapsone as well as systemic steroids and infliximab that is currently well controlled with the addition of oral tacrolimus. To our knowledge, this is the first report of the effective, safe use of oral tacrolimus in combination with infliximab for infantile pyoderma gangrenosum. We review all current cases of infantile pyoderma gangrenosum, as well as tacrolimus and its role in the treatment of this condition.

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“…Pyoderma Gangrenosum (PG) is a neutrophilic dermatosis that was first described by Brunsting et al in 1930 [1]. The pathogenesis is poorly understood, several diseases and conditions associated with PG have been described such as Crohn's disease, ulcerative colitis, polyarthritis, diabetes, myelodysplastic syndromes or myeloid leukemia, monoclonal gammopathy, and systemic lupus erythematosus [2]. Several cases have also been reported after surgery [3].…”

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confidence: 99%

“…PG is a diagnosis of elimination, after exclusion of other ulcerative processes. Histopathologic examination shows a dense inflammatory infiltrate of polymorphonuclear leukocytes associated with fibrinoid necrosis of the vessel wall [2]. Treatment is based primarily on systemic corticosteroid therapy, cyclosporine, and dapsone [5].…”

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confidence: 99%