Pyoderma gangrenosum‐like ulcer caused by <i>Helicobacter cinaedi</i> in a patient with hypogammaglobulinemia

Harada, Kazutoshi; Nakamura, Itaru; Gotoh, Moritaka; Tsuboi, Ryoji

doi:10.1111/1346-8138.14012

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Indeed, the clinical courses and outcomes, such as complications and need for surgical treatments, in-hospital days, and mortality, were not aggravated in the present study. On the contrary, immunocompromised patients, especially those with recent chemotherapy, were likely admitted at the first visit to the ED in the present study, and previous studies also pointed out that those patients are at risk for recurrence [8,9,[22][23][24][25][26][27].…”

Section: Discussionmentioning

confidence: 51%

Helicobacter cinaedi Infections in Emergency Departments: A Descriptive Study

Izuta,

Matsuoka,

Hasuike

et al. 2023

Cureus

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Aim: Helicobacter cinaedi , a Gram-negative spiral bacterium, is a rare cause of bacteremia in humans. Unfortunately, little is known about H. cinaedi infections in emergency departments (EDs). We aimed to describe the clinical features of H. cinaedi infections in the ED. Methods: We conducted a descriptive study at the ED of Kobe City General Hospital (KCGH) in Japan between November 2011 and December 2020. We included all ED patients with H. cinaedi infections. We retrospectively obtained the patient data from electronic medical records and described the patient characteristics, clinical course, and management of H. cinaedi infections. Results: A total of 22 patients in the ED were diagnosed with H. cinaedi infections, and all of them were detected through blood cultures. The chief complaints were vague: fever (18/22, 81.8%), chills (10/22, 45.5%), and localized pain or tenderness (8/22, 36.4%). Patients with complicated cases were also reported in the ED; three patients had vertebral osteomyelitis, two had infected aortic aneurysms, and another two had infected cysts (renal cyst and pancreatic cyst with concomitant empyema). Tetracycline (minocycline) was primarily prescribed and administered intravenously in five of 15 (33.3%) and orally in nine of 20 (45.0%) patients. Only one (4.5%) patient required surgical interventions. None of the patients died in the hospital. Conclusions: We reported the clinical features of H. cinaedi infections in the ED. Although some patients developed complicated infections, the prognosis was not poor under appropriate treatment, and most of them were successfully treated with antibiotics, primarily tetracycline.

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Section: Discussionmentioning

confidence: 51%

Helicobacter cinaedi Infections in Emergency Departments: A Descriptive Study

Izuta,

Matsuoka,

Hasuike

et al. 2023

Cureus

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“…Most infections with enterohepatic NHPH species are initially detected in the skin. They are diagnosed initially as cellulitis and in some cases progress to PG-like ulcer (Harada et al, 2017). When these infections are not cleared despite antibiotic therapy, they progress to osteomyelitis and sepsis (Simons et al, 2004;Yoda et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Infections With Enterohepatic Non-H. pylori Helicobacter Species in X-Linked Agammaglobulinemia: Clinical Cases and Review of the Literature

Romo-González¹,

Ogando²,

Yamazaki‐Nakashimada³

et al. 2022

Front. Cell. Infect. Microbiol.

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The genus Helicobacter is classified into two main groups according to its habitat: gastric and enterohepatic. Patients with X-linked agammaglobulinemia (XLA) appear to be associated with invasive infection with enterohepatic non-Helicobacter pylori species (NHPH), mainly H. cinaedi and H. bilis. Such infections are difficult to control and have a high potential for recurrence. The spectrum of illnesses caused by these species includes recurrent fever, bacteremia, arthritis, osteomyelitis, cellulitis, abdominal abscesses, and pyoderma gangrenosum-like ulcer. The presence of these Helicobacters is particularly difficult to diagnose and eradicate, as they are very fastidious bacteria and present resistance to several types of antibiotics. We report two clinical cases of XLA patients infected with H. bilis. These infections were chronic in these patients and could not be eradicated in one of them. We also review the cases of enterohepatic non-Helicobacter pylori species (NHPH) in patients with this inborn error of immunity.

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Antineoplastics

2018

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Pyoderma gangrenosum‐like ulcer caused by Helicobacter cinaedi in a patient with hypogammaglobulinemia

Cited by 4 publications

References 6 publications

Helicobacter cinaedi Infections in Emergency Departments: A Descriptive Study

Helicobacter cinaedi Infections in Emergency Departments: A Descriptive Study

Infections With Enterohepatic Non-H. pylori Helicobacter Species in X-Linked Agammaglobulinemia: Clinical Cases and Review of the Literature

Antineoplastics

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