Pyostomatitis vegetans (PSV)-pyodermatitis vegetans (PDV): A clinicopathologic study of 7 cases at a tertiary referral center

Pyodermatitis‐pyostomatitis vegetans associated with asymptomatic inflammatory bowel disease

“…Cutaneous and mucosal lesions have similar histopathological features that include epidermal hyperplasia and a dense mixed dermal inflammatory infiltrate . Exocytosis of eosinophils and neutrophils and formation of distinctive intraepithelial and subepithelial microabscesses containing neutrophils and eosinophils are reported . Focal acantholysis, superficial ulceration, and subcorneal neutrophilic pustules may also be present .…”

“…Oral lesions consist of multiple pustules that result in shallow ulcerations with a typical “snail track” appearance . Cutaneous and mucosal lesions have similar histopathological features that include epidermal hyperplasia and a dense mixed dermal inflammatory infiltrate . Exocytosis of eosinophils and neutrophils and formation of distinctive intraepithelial and subepithelial microabscesses containing neutrophils and eosinophils are reported .…”

“…Exocytosis of eosinophils and neutrophils and formation of distinctive intraepithelial and subepithelial microabscesses containing neutrophils and eosinophils are reported . Focal acantholysis, superficial ulceration, and subcorneal neutrophilic pustules may also be present . In contrast to pemphigus vegetans, DIF and IIF studies are typically negative.…”

Disfiguring facial pyoderma vegetans with an excellent outcome

“…In contrast to PV, cases of PG do not appear to closely correlate with inflammatory bowel disease activity 28. Large case series have reported that eosinophilia on histopathology, and to a lesser extent peripheral eosinophilia, may be helpful in distinguishing PV from PG 28. Notably, our patient had a transient peripheral blood eosinophilia at the time of presentation, which in conjunction with the pattern of clinical features supported the diagnosis of PV.…”

“…In contrast to PV, cases of PG do not appear to closely correlate with inflammatory bowel disease activity 28. Large case series have reported that eosinophilia on histopathology, and to a lesser extent peripheral eosinophilia, may be helpful in distinguishing PV from PG 28.…”