Pyrazolone Derivatives as Analytical Reagents

Abstract

Illinois 601 15. USC M S . received 14th M a y 1970Ahtract. Starting from bare-ion pseudopotentials, net crystal potentials are evalutiied in direct space by (a) the usual linear screening technique and (b) the Thomas-Fermi method. For the metals considered (Na and AI), the potentials are quite similar, crossing outside the cores and never differing by more than 0.02 a.u. in the case of Na nor by more than 0.2 a.u. in the case of Al. The similarity of the results based on (a) and (b) suggest the use of the pseudopotential concept in conjunction with the rather general method (b) under conditions when (a) is questionable, that is whenever the zeroth order uniform electron gas solution is a poor physical approximation to the actual system under study (specific examples being molecules, insulating solids and interfaces).Methods (a) and (bj both yield shallower wells than those most often used as input information in band structure calculations and obtained by superposing atomic data.

Novel Regioselective Synthesis of 1,3,4,5-Tetrasubstituted Pyrazoles and Biochemical Valuation on F1FO-ATPase and Mitochondrial Permeability Transition Pore Formation

“…Pzs show a large number of applications due to the aromatic character of the heterocycle core that makes them resistant to oxidation, reduction, and acid or basic hydrolysis [ 2 ]. For this reason, Pz derivatives are useful as agrochemicals, such as insecticides, fungicides, and herbicides [ 3 , 4 ]; or as dyes [ 5 ], sunscreen materials [ 6 ], analytical reagents [ 7 ], and powerful ligands in coordination chemistry [ 8 ]. In addition, polyaromatic pyrazoles have important photophysical, optical, and electronic properties [ 5 , 9 ].…”

Revisiting the Chemistry of Vinylpyrazoles: Properties, Synthesis, and Reactivity

“…Pyrazoles have attracted increased attention in recent years owing to their widespread applications in medicine [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ], agriculture, [ 16 ] materials science [ 17 , 18 , 19 , 20 ], and catalysis [ 21 , 22 ]. In this review, the chemistry of a particular kind of pyrazoles, the vinylpyrazoles, is revisited.…”

Styrylpyrazoles: Properties, Synthesis and Transformations

“…Along with the medicinal applications, pyrazoles are also useful as agrochemicals, such as herbicides, others [15][16][17][18][19][20][21]. Along with the medicinal applications, pyrazoles are also useful as agrochemicals, such as herbicides, fungicides, and insecticides [22] and possess other applications, such as dyestuffs, sunscreen materials [23,24], analytical reagents and pluripotent ligands in coordination chemistry [25,26]. For instance, polyaromatic pyrazoles possess important biological, photophysical, optical and electronic properties [10,[27][28][29].…”

“…Pyrazole and its derivatives occupy a prime place in medicinal chemistry because they are present in several drugs with real medicinal applications, such as celecoxib (Celebrex ® ), sildenafil (Viagra ® ), rimonabant, lonazolac, fomepizole, penthiopyrad, doramapimod, sulfaphenazole and in several remarkable compounds with a wide range of pharmacological activities, namely anticancer [ 3 ], analgesic, anti-inflammatory and antioxidant [ 4 , 5 , 6 , 7 ], antibacterial and antifungal [ 8 , 9 ] antipyretic, antidepressant and anticonvulsant [ 10 , 11 ], antidiabetic [ 12 ] and cannabinoid activities [ 13 , 14 ], among others [ 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. Along with the medicinal applications, pyrazoles are also useful as agrochemicals, such as herbicides, fungicides, and insecticides [ 22 ] and possess other applications, such as dyestuffs, sunscreen materials [ 23 , 24 ], analytical reagents and pluripotent ligands in coordination chemistry [ 25 , 26 ]. For instance, polyaromatic pyrazoles possess important biological, photophysical, optical and electronic properties [ 10 , 27 , 28 , 29 ].…”