Pyridine derivatives as preferable scaffolds for the process of discovering new drugs

Abstract

The pyridine ring is present in numerous significant plant compounds. It is used as a therapeutic to boost the solubility and bioavailability of less soluble chemicals since it is a polar and ionizable aromatic molecule. Chemical compounds derived from pyridine are highly sought-after in the pharmaceutical industry. An essential synthesis strategy in the search for novel medications is the fusion of the pyridine nucleus. Due to the compounds’ powerful therapeutic characteristics, medicinal chemists have long been fascinated by the chemistry of pyridine and its derivatives, which inspires them to look for and make novel compounds with biological utility. There are significant ramifications for medical chemistry in the adaptability of pyridine and its derivatives as reactants and starting materials for structural changes. Pesticides and agricultural chemicals that heavily rely on pyridine derivatives include insecticides, fungicides, and herbicides; However, this page focuses on their medical applications. Pyridine derivatives are frequently used in the textile industry to create dyes. We present the most recent findings from 2010 onward, highlighting the growing significance of pyridine scaffolds in medicinal chemistry and the development of new drugs. Even though there are a lot of studies on pyridine derivatives, this chapter only has compounds with a clear pharmacophore.