A dual-target uorescent chemosensor BQC (((E)-N-benzhydryl-2-(quinolin-2-ylmethylene)hydrazine-1carbothioamide) was synthesized for detecting In 3+ and ClO − . BQC displayed green and blue uorescence responses to In 3+ and ClO − with low detection limits (0.83 µM for In 3+ and 2.50 µM for ClO − ), respectively. Importantly, BQC is the rst uorescent chemosensor capable of detecting In 3+ and ClO − . The binding ratio between BQC and In 3+ was determined to be a 2:1 through Job plot and ESI-MS analysis. BQC could be successfully utilized as a visible test kit to detect In 3+ . Meanwhile, BQC showed a selective turn-on response to ClO − even in the presence of anions or reactive oxygen species. The sensing mechanisms of BQC for In 3+ and ClO − were demonstrated by 1 H NMR titration, ESI-MS and theoretical calculations.