Pyridoxal derivatized copper(II) complexes: Evaluation of antioxidant, catecholase, and DNA cleavage activity

Pereira, Mateus Brum; Fontana, Liniquer A.; Siqueira, Josiéli Demetrio; Auras, Bruna L.; Silva, Marcos Da; Neves, Ademir; Gabriel, Philipe; Terenzi, Hernán; Iglesias, Bernardo A.; Back, Davi F.

doi:10.1016/j.ica.2017.09.063

Cited by 19 publications

(4 citation statements)

References 72 publications

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“…Numerous reports can be found in the literature that illustrate the use of high-resolution tandem mass spectrometry (MS/MS) for the characterization of proteins [46][47][48][49], identification of peptide [50][51][52], untargeted screening of lipids [53], investigation of rhamnogalacturonan II pectin [54], and quantification of transfucosylation products for manufacturing biomimetic human milk oligosaccharides [55]. Other investigations varied from the synthesis of diarylethene fluorescence probes with a methylquinoline moiety [56], analysis of intermediates produced in the sulfamethoxazole photodegradation process [57], identification of isopropylphenol oxidation products [58], analysis of carotenoids in citrus [59], and chemical structure confirmation of phenolic compounds [60] to a wide range of bioanalytical applications using electrospray ionization (ESI) [61][62][63][64][65][66][67]. This literature review emphasizes both the versatility of ESI-ITMS as an analytical tool and the novelty of our BPA adsorption/desorption study uniquely with TiO 2 nanoparticles or milk proteins.…”

Section: Introductionmentioning

confidence: 99%

Ion-Trap Mass Spectrometric Analysis of Bisphenol A Interactions With Titanium Dioxide Nanoparticles and Milk Proteins

2020

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Quantitative analysis of endocrine-disrupting molecules such as bisphenol A (BPA) in freshwater to determine their widespread occurrence in environmental resources has been challenged by various adsorption and desorption processes. In this work, ion trap mass spectrometry (ITMS) analysis of BPA was aimed at studying its molecular interactions with titanium dioxide (TiO2) nanoparticles and milk whey proteins. Addition of sodium formate prevented TiO2 nanoparticles from sedimentation while enhancing the electrospray ionization (ESI) efficiency to produce an abundance of [BPA + Na]+ ions at m/z 251.0. More importantly, the ESI-ITMS instrument could operate properly during a direct infusion of nanoparticles up to 500 μg/mL without clogging the intake capillary. Milk protein adsorption of BPA could decrease the [BPA + Na]+ peak intensity significantly unless the proteins were partially removed by curdling to produce whey, which allowed BPA desorption during ESI for quantitative analysis by ITMS.

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Section: Introductionmentioning

confidence: 99%

Ion-Trap Mass Spectrometric Analysis of Bisphenol A Interactions With Titanium Dioxide Nanoparticles and Milk Proteins

2020

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“…Once the molecular structure of this enzyme in plants has been elucidated, various transition metal complexes have been tested as catalysts for catechol‐quinone conversion . Among them, catecholase activity of Cu (II), Mn (II, III, IV), Fe (III), Co (II/III), Ni (II) and Zn (II) complexes have reported …”

Section: Introductionmentioning

confidence: 99%

Triazine based Mn (II) and Mn (II)/Ln (III) complexes: Synthesis, characterization and catecholase activities

Çelik

Köse

2018

Applied Organom Chemis

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In the current work, two triazine‐based multidentate ligands (H2L1 and H2L2) and their homo‐dinuclear Mn (II), mononuclear Ln (III) and hetero‐dinuclear Mn (II)/Ln (III) (Where Ln: Eu or La) complexes were synthesized and characterized by spectroscopic and analytical methods. Single crystals of a homo‐dinuclear Mn (II) complex {[Mn (HL1)(CH3OH)](ClO4·CH3OH}2 (1) were obtained and the molecular structure was determined by X‐ray diffraction method. In the structure of the complex, each Mn (II) ion is seven‐coordinate and one of the phenolic oxygen bridges two Mn (II) centre forming a dimeric structure. The UV–Vis. and photoluminescence properties of synthesized ligands and their metal complexes were investigated in DMF solution and the compounds showed emission bands in the UV–Vis. region. The catecholase enzyme‐like activity of the complexes were studied for 3,5‐DTBC → 3,5‐DTBQ conversion in the presence of air oxygen. Homo‐dinuclear Mn (II) complexes (1 and 4) were found to efficiently catalyse 3,5‐DTBC → 3,5‐DTBQ conversion with the turnover numbers of 37.25 and 35.78 h−1 (kcat), respectively. Mononuclear Eu (III) and La (III) complexes did not show catecholase activity.

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“…13,14 However, the combination of a distorted geometry and close M•••F contacts has not been reported so far; in other cases, M•••F contacts are axial, allowing the conventional (N, O) donor ligands to adopt a square-planar geometry. 15,16…”

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confidence: 99%

“…Due to its d 9 electron configuration giving rise to a classic Jahn–Teller distortion, Cu(II) tends to form complexes that are square planar or octahedral with axial elongation, yet tetrahedral distortions are quite common . In a number of cases, interligand steric repulsion leads to a distorted geometry. , However, the combination of a distorted geometry and close M···F contacts has not been reported so far; in other cases, M···F contacts are axial, allowing the conventional (N, O) donor ligands to adopt a square-planar geometry. , …”

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Distorted Copper(II) Complex with Unusually Short CF···Cu Distances

et al. 2021

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We find a Cu(II)-(L-CF 3 ) 2 complex (L-CF 3 = 2,2,2-trifluoro-N-[2-(pyridin-2-yl)propan-2-yl]acetamide) with a distorted "seesaw" geometry. It has the shortest crystallographic CF•••Cu distances yet reported, to the best of our knowledge (<2.6 Å), for which computational and experimental data indicate a secondary bonding interaction. A comparison with a CCl 3 version and one without ligand backbone gem-dimethyl groups suggests a steric origin for the distorted geometry, resulting from the specific ligand interactions.

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Pyridoxal derivatized copper(II) complexes: Evaluation of antioxidant, catecholase, and DNA cleavage activity

Cited by 19 publications

References 72 publications

Ion-Trap Mass Spectrometric Analysis of Bisphenol A Interactions With Titanium Dioxide Nanoparticles and Milk Proteins

Ion-Trap Mass Spectrometric Analysis of Bisphenol A Interactions With Titanium Dioxide Nanoparticles and Milk Proteins

Triazine based Mn (II) and Mn (II)/Ln (III) complexes: Synthesis, characterization and catecholase activities

Distorted Copper(II) Complex with Unusually Short CF···Cu Distances

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