Pyrophosphate functionalized silver nanoparticles for colorimetric determination of deferiprone via competitive binding to Fe(III)

Chavada, Vijay D.; Bhatt, Nejal M.; Sanyal, Mallika; Shrivastav, Pranav S.

doi:10.1007/s00604-017-2417-7

Cited by 17 publications

(4 citation statements)

References 22 publications

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“…The clinically used chelator, desferrioxamine-loaded polymeric nanoparticles (NPs) containing galactose as the targeting ligand were prepared in another study for targeted drug delivery to asialoglycoprotein receptors in hepatocytes [ 124 ]. Zinc oxide nanocrystals–methylene blue nanocomposites [ 125 ], pyrophosphate functionalized silver nanoparticles (Pyro-AgNPs) [ 126 ], gold nanorods [ 127 ], and HRP–AuNP–CaCO 3 composites [ 128 ] have been developed to sense deferiprone in vitro, which is an anti-thalassemic iron chelating drug.…”

Section: Nanotechnology For the Treatment Of Complications Of Thalass...mentioning

confidence: 99%

Thalassemia and Nanotheragnostics: Advanced Approaches for Diagnosis and Treatment

Tariq

Qadeer²,

Anjum

et al. 2023

Biosensors

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Thalassemia is a monogenic autosomal recessive disorder caused by mutations, which lead to abnormal or reduced production of hemoglobin. Ineffective erythropoiesis, hemolysis, hepcidin suppression, and iron overload are common manifestations that vary according to genotypes and dictate, which diagnosis and therapeutic modalities, including transfusion therapy, iron chelation therapy, HbF induction, gene therapy, and editing, are performed. These conventional therapeutic methods have proven to be effective, yet have several disadvantages, specifically iron toxicity, associated with them; therefore, there are demands for advanced therapeutic methods. Nanotechnology-based applications, such as the use of nanoparticles and nanomedicines for theragnostic purposes have emerged that are simple, convenient, and cost-effective methods. The therapeutic potential of various nanoparticles has been explored by developing artificial hemoglobin, nano-based iron chelating agents, and nanocarriers for globin gene editing by CRISPR/Cas9. Au, Ag, carbon, graphene, silicon, porous nanoparticles, dendrimers, hydrogels, quantum dots, etc., have been used in electrochemical biosensors development for diagnosis of thalassemia, quantification of hemoglobin in these patients, and analysis of conventional iron chelating agents. This review summarizes the potential of nanotechnology in the development of various theragnostic approaches to determine thalassemia-causing gene mutations using various nano-based biosensors along with the employment of efficacious nano-based therapeutic procedures, in contrast to conventional therapies.

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Section: Nanotechnology For the Treatment Of Complications Of Thalass...mentioning

confidence: 99%

Thalassemia and Nanotheragnostics: Advanced Approaches for Diagnosis and Treatment

Tariq

Qadeer²,

Anjum

et al. 2023

Biosensors

View full text Add to dashboard Cite

show abstract

“…The selectivity was verified since no responses were obtained in the presence of many amino acids, saccharides, and inorganic ions. The method was applied for determining deferiprone in commercial drugs and a spiked human plasma demonstrating good accuracy, so this innovative and cheap assay can be promising for deferiprone dosage in biological fluids and pharmaceutics [93].…”

Section: Colorimetric Sensors Based On Agnps Anti-aggregationmentioning

confidence: 99%

Gold and Silver Nanoparticle-Based Colorimetric Sensors: New Trends and Applications

et al. 2021

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Gold and Silver nanoparticles (AuNPs and AgNPs) are perfect platforms for developing sensing colorimetric devices thanks to their high surface to volume ratio and distinctive optical properties, particularly sensitive to changes in the surrounding environment. These characteristics ensure high sensitivity in colorimetric devices. Au and Ag nanoparticles can be capped with suitable molecules that can act as specific analyte receptors, so highly selective sensors can be obtained. This review aims to highlight the principal strategies developed during the last decade concerning the preparation of Au and Ag nanoparticle-based colorimetric sensors, with particular attention to environmental and health monitoring applications.

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“…目前, 基于纳米酶的传感方法已广泛应用于免疫分析 [20,21] 、核酸检测 [22] 、重金属离子检测 [23] 、农药残留检测 [24] 、食品安全监测 [25] 和药品质量控制 [26] 等. [27,28] . 相比当前定量检测DFP的主要方法如荧光法 [29,30] 、电化学法 [31] 、高效液相色谱法 [32] 、液相色谱-串联质谱法…”

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Colorimetric detection of thalassaemia therapeutic drug deferiprone through tuning the peroxidase-like activity of MoS<sub>2</sub> quantum dots

Tan¹,

Xia²,

Fu³

et al. 2021

Sci. Sin.-Chim

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Precisely regulating the catalytic activity of nanozymes is of great significance for their applications in sensing, biomedicine, etc. In this work, the peroxidase-like activity of MoS 2 quantum dots (QDs) is controlled by regulating their aggregation or disaggregation in aqueous solution. Specifically, monodispersed MoS 2 QDs show very weak peroxidase-like activity. Fe 3+ ions can induce significant aggregation of MoS 2 QDs in aqueous solution and thus greatly enhance their activity. However, the drug deferiprone that commonly used for thalassaemia treatment can selectively bind with Fe 3+ via complexation, thus inhibiting the aggregation of MoS 2 QDs and their enhancement of enzyme-like activity. Based on this mechanism, a new colorimetric method for the detection of deferiprone is developed and further successfully applied to the quality control of drug. Moreover, with the aid of photographing and chroma analysis by a smartphone, a smartphone-based analytical method for deferiprone is also established, which is expected to be extended to point-of-care testing and diagnosis.

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Pyrophosphate functionalized silver nanoparticles for colorimetric determination of deferiprone via competitive binding to Fe(III)

Cited by 17 publications

References 22 publications

Thalassemia and Nanotheragnostics: Advanced Approaches for Diagnosis and Treatment

Thalassemia and Nanotheragnostics: Advanced Approaches for Diagnosis and Treatment

Gold and Silver Nanoparticle-Based Colorimetric Sensors: New Trends and Applications

Colorimetric detection of thalassaemia therapeutic drug deferiprone through tuning the peroxidase-like activity of MoS<sub>2</sub> quantum dots

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Pyrophosphate functionalized silver nanoparticles for colorimetric determination of deferiprone via competitive binding to Fe(III)

Cited by 17 publications

References 22 publications

Thalassemia and Nanotheragnostics: Advanced Approaches for Diagnosis and Treatment

Thalassemia and Nanotheragnostics: Advanced Approaches for Diagnosis and Treatment

Gold and Silver Nanoparticle-Based Colorimetric Sensors: New Trends and Applications

Colorimetric detection of thalassaemia therapeutic drug deferiprone through tuning the peroxidase-like activity of MoS&lt;sub&gt;2&lt;/sub&gt; quantum dots

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Colorimetric detection of thalassaemia therapeutic drug deferiprone through tuning the peroxidase-like activity of MoS<sub>2</sub> quantum dots