Pyroptosis, a New Breakthrough in Cancer Treatment

Wu, Dengqiang; Wei, Changhong; Li, Yujie; Yang, Xuejia; Zhou, Sufang

doi:10.3389/fonc.2021.698811

Cited by 34 publications

(29 citation statements)

References 170 publications

(199 reference statements)

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“…Deregulation of apoptosis is considered one of the characteristics of cancer progression, and transformed cells are able to circumvent this process, although the mechanisms involved are not sufficiently known. For this reason, therapeutic strategies aimed at restoring the sensitivity of cancer cells to apoptosis are increasingly tested [113][114][115]. Citrus fruits represent major sources of flavonoids.…”

Section: Natural Compounds and Cancer: Cellular Viabilitymentioning

confidence: 99%

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Nutraceuticals and Cancer: Potential for Natural Polyphenols

et al. 2021

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Cancer is one of the leading causes of death globally, associated with multifactorial pathophysiological components. In particular, genetic mutations, infection or inflammation, unhealthy eating habits, exposition to radiation, work stress, and/or intake of toxins have been found to contribute to the development and progression of cancer disease states. Early detection of cancer and proper treatment have been found to enhance the chances of survival and healing, but the side effects of anticancer drugs still produce detrimental responses that counteract the benefits of treatment in terms of hospitalization and survival. Recently, several natural bioactive compounds were found to possess anticancer properties, capable of killing transformed or cancerous cells without being toxic to their normal counterparts. This effect occurs when natural products are associated with conventional treatments, thereby suggesting that nutraceutical supplementation may contribute to successful anticancer therapy. This review aims to discuss the current literature on four natural bioactive extracts mostly characterized by a specific polyphenolic profile. In particular, several activities have been reported to contribute to nutraceutical support in anticancer treatment: (1) inhibition of cell proliferation, (2) antioxidant activity, and (3) anti-inflammatory activity. On the other hand, owing to their attenuation of the toxic effect of current anticancer therapies, natural antioxidants may contribute to improving the compliance of patients undergoing anticancer treatment. Thus, nutraceutical supplementation, along with current anticancer drug treatment, may be considered for better responses and compliance in patients with cancer. It should be noted, however, that when data from studies with bioactive plant preparations are discussed, it is appropriate to ensure that experiments have been conducted in accordance with accepted pharmacological research practices so as not to disclose information that is only partially correct.

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Section: Natural Compounds and Cancer: Cellular Viabilitymentioning

confidence: 99%

“…In addition, oleuropein induced the downregulation of metalloproteinase genes, which may be involved in the prevention of breast cancer metastases [113,116,181]. An antioxidant and growth inhibitory effect was found for differentiated thyroid cancer [115].…”

Section: Antioxidant Effect Of Natural Compounds On Cancermentioning

confidence: 99%

Nutraceuticals and Cancer: Potential for Natural Polyphenols

et al. 2021

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“…We obtained 52 pyroptosis-related genes (PRGs) from prior reviews (Xia et al, 2019;Zhou and Fang, 2019;Li et al, 2020;Ju X. et al, 2021;Wu et al, 2021;Ye et al, 2021) and MSigDB database v7.4 (Subramanian et al, 2005) (listed in Supplementary Table S1). We identified DEPRGs between tumor and normal tissues using the "limma" package, with a p-value < 0.05.…”

Section: Identification Of Deprgsmentioning

confidence: 99%

“…Pyroptosis is a newly discovered form of programmed cell death that is morphologically distinct from apoptosis and necrosis while releasing inflammatory mediators in the process (Wu et al, 2021). Pyroptosis is mediated by pore-forming proteins, such as the gasdermin family, of which gasdermin D (GSDMD) is a primary substrate for the caspase family (Li L. et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma

Zhang

Liu

et al. 2021

Front. Genet.

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Osteosarcoma is a common malignant bone tumor with a propensity for drug resistance, recurrence, and metastasis. A growing number of studies have elucidated the dual role of pyroptosis in the development of cancer, which is a gasdermin-regulated novel inflammatory programmed cell death. However, the interaction between pyroptosis and the overall survival (OS) of osteosarcoma patients is poorly understood. This study aimed to construct a prognostic model based on pyroptosis-related genes to provide new insights into the prognosis of osteosarcoma patients. We identified 46 differentially expressed pyroptosis-associated genes between osteosarcoma tissues and normal control tissues. A total of six risk genes affecting the prognosis of osteosarcoma patients were screened to form a pyroptosis-related signature by univariate and LASSO regression analysis and verified using GSE21257 as a validation cohort. Combined with other clinical characteristics, including age, gender, and metastatic status, we found that the pyroptosis-related signature score, which we named “PRS-score,” was an independent prognostic factor for patients with osteosarcoma and that a low PRS-score indicated better OS and a lower risk of metastasis. The result of ssGSEA and ESTIMATE algorithms showed that a lower PRS-score indicated higher immune scores, higher levels of tumor infiltration by immune cells, more active immune function, and lower tumor purity. In summary, we developed and validated a pyroptosis-related signature for predicting the prognosis of osteosarcoma, which may contribute to early diagnosis and immunotherapy of osteosarcoma.

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“…Pyroptosis is a programmed cell death process that was first described when primary mouse macrophages were treated with an anthrax lethal toxin [ 1 , 2 , 3 , 4 , 5 , 6 ]. It was mistakenly reported as apoptosis when the macrophages were infected with Shigella flexneri in 1992 [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Pan-Cancer Analyses of Pyroptosis-Related Genes to Predict Survival and Immunotherapeutic Outcome

Wang

Liu

et al. 2022

Cancers

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Pyroptosis is a newly characterized type of programmed cell death. However, its function in cancer progression and its response to treatments remain controversial. Here, we extensively and systematically compiled genes associated with pyroptosis, integrated multiomics data and clinical data across 31 cancer types from The Cancer Genome Atlas, and delineated the global alterations in PRGs at the transcriptional level. The underlying transcriptional regulations by copy number variation, miRNAs, and enhancers were elucidated by integrating data from the Genotype-Tissue Expression and International Cancer Genome Consortium. A prognostic risk model, based on the expression of PRGs across 31 cancer types, was constructed. To investigate the role of pyroptosis in immunotherapy, we found five PRGs associated with effectiveness by exploring the RNA-Seq data of patients with immunotherapy, and further identified two small-molecule compounds that are potentially beneficial for immunotherapy. For the first time, from a pyroptosis standpoint, this study establishes a novel strategy to predict cancer patient survival and immunotherapeutic outcomes.

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Pyroptosis, a New Breakthrough in Cancer Treatment

Cited by 34 publications

References 170 publications

Nutraceuticals and Cancer: Potential for Natural Polyphenols

Nutraceuticals and Cancer: Potential for Natural Polyphenols

A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma

Comprehensive Pan-Cancer Analyses of Pyroptosis-Related Genes to Predict Survival and Immunotherapeutic Outcome

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