Pyrrole Insecticides: A New Class of Agriculturally Important Insecticides Functioning as Uncouplers of Oxidative Phosphorylation

Hunt, David A.; Treacy, M. F.

doi:10.1007/978-3-662-03565-8_8

Cited by 37 publications

(33 citation statements)

References 17 publications

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“…Chlorfenapyr acts as a decoupler of the oxidative phosphorylation, and this compound must be previously enabled via oxidative removal of the N-etoxymethyl group to present a lethal effect in the organism (Yu 2008). Thus, this product is able to inhibit ATP production, leading to death (Hunt and Tracy 1998). Kim and Yoo (2002) observed that the survival of Phytoseiulus persimilis Athias-Henriot is reduced over time upon exposure to chlorfenapyr.…”

Section: Discussionmentioning

confidence: 98%

Survival and behavioural response to acaricides of the coconut mite predator Neoseiulus baraki

et al. 2012

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The coconut mite, Aceria guerreronis Keifer, is a major pest of coconut palm in the world. The control of this pest species is done through acaricide applications at short time intervals. However, the predators of this pest may also be affected by acaricides. Among the predators of A. guerreronis, Neoseiulus baraki (Athias-Henriot) has potential for biological control. The objective of this study was to assess the effect of acaricides on the survival and behavior of N. baraki. The survivorship of N. baraki was recorded in surface-impregnated arenas. Choice and no-choice behavioral bioassays were carried out using a video tracking system to assess the walking behavior of the predator under acaricide exposure. Although all acaricides negatively affected the survival of N. baraki, chlorfenapyr and azadirachtin caused lower effect than the other acaricides. No significant differences in walking behavior were observed under exposure to fenpyroximate, chlorfenapyr and chlorpyrifos on fully-contaminated arenas. Azadirachtin and chlorpyrifos caused repellence. Irritability was observed for all acaricides, except for abamectin. Chlorfenapyr was the most suitable product for managing the coconut mite because of its low effect on survival and behavior of N. baraki.

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Section: Discussionmentioning

confidence: 98%

Survival and behavioural response to acaricides of the coconut mite predator Neoseiulus baraki

et al. 2012

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“…Chlorfenapyr, a novel N-substituted halogenated pyrrole, is a wide-spectrum insecticide with an acaricidal activity (Hunt and Treacy 1998). Chlorfenapyr is a proinsecticide activated by the in vivo oxidative elimination of its N-ethoxymethyl group by mixed function oxidases (Black et al 1994).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and genotoxic effects of abamectin, chlorfenapyr, and imidacloprid on CHOK1 cells

Al‐Sarar

Abobakr

Bayoumi

et al. 2015

Environ Sci Pollut Res

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The cytotoxicity and genotoxicity of abamectin, chlorfenapyr, and imidacloprid have been evaluated on the Chinese hamster ovary (CHOK1) cells. Neutral red incorporation (NRI), total cellular protein content (TCP), and methyl tetrazolium (MTT) assays were followed to estimate the mid-point cytotoxicity values, NRI50, TCP50, and MTT50, respectively. The effects of the sublethal concentration (NRI25) on glutathione S-transferase (GST), glutathione reductase (GRD), glutathione peroxidase (GPX), and total glutathione content have been evaluated in the presence and absence of reduced glutathione (GSH), vitamin C, and vitamin E. The genotoxicity was evaluated using chromosomal aberrations (CA), micronucleus (MN) formation, and DNA fragmentation techniques in the presence and absence of the metabolic activation system, S9 mix. Abamectin was the most cytotoxic pesticide followed by chlorfenapyr, while imidacloprid was the least cytotoxic one. The glutathione redox cycle components were altered by the tested pesticides in the absence and presence of the tested antioxidants. The results of genotoxicity indicate that abamectin, chlorfenapyr, and imidacloprid have potential genotoxic effects on CHOK1 cells under the experimental conditions.

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“…Acetamiprid has contact, translaminar, and systemic activity, whereas thiamethoxam has systemic activity and long residual activity in several plants (McLeod et al 2002). Chlorfenapyr is a group 13A insecticide that requires activation by the insectÕs own defensive biochemical pathways, creating an active molecule that interferes with oxidative phosphorylation (Hunt and Treacy 1998), and it is the only insecticide in its group (Ware and Whitacre 2004). All three insecticides are regarded to be "reduced risk" insecticides because their spectrum of activity is narrow.…”

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confidence: 99%

Potential New Insecticides for the Control of Western Flower Thrips (Thysanoptera: Thripidae) on Sweet Pepper, Tomato, and Lettuce

Broughton

Herron

2009

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New pesticides are required to maintain effective resistance management strategies for control of western flower thrips, Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae). We tested the efficacy of acetamiprid, and thiamethoxam, two neonicotinoids that represent a newer class of insecticides for the control of thrips. We also tested chlorfenapyr, a pyrrol compound, and a lower than registered rate of the biopesticide spinosad. Laboratory bioassays were used to predict the relative efficacy of insecticides against F. occidentalis and to forecast likely field rates. Two doses within the calculated LC99.99 range were used to predict field rates and trial rates of 0.5 g and 1.0 active ingredient (AI)/liter acetamiprid, 0.025 and 0.05 g (AI)/liter chlorfenapyr, 0.3 and 0.6 g (AI)/liter thiamethoxam, and 0.01 g (AI)/ liter spinosad were tested in the greenhouse against pepper, lettuce, and tomato. With the exception of acetamiprid, field trial doses predicted from laboratory bioassay translated to effective field efficacy. All products controlled F. occidentalis at the rates trialed and so have potential to augment current chemical controls. Increasing mortality correlated with increasing acetamiprid concentration in a greenhouse lettuce trial, suggesting that the higher trial rate (1.0 g [AI]/liter) may be required in some lettuce crops. The lower than registered (0.01 g [AI]/liter) rate of spinosad also significantly reduced F. occidentalis numbers and is a viable control option that may be useful in specific integrated pest management programs. The implications of introducing neonicotinoids into existing insecticide resistance management strategies for F. occidentalis are discussed.

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Pyrrole Insecticides: A New Class of Agriculturally Important Insecticides Functioning as Uncouplers of Oxidative Phosphorylation

Cited by 37 publications

References 17 publications

Survival and behavioural response to acaricides of the coconut mite predator Neoseiulus baraki

Survival and behavioural response to acaricides of the coconut mite predator Neoseiulus baraki

Cytotoxic and genotoxic effects of abamectin, chlorfenapyr, and imidacloprid on CHOK1 cells

Potential New Insecticides for the Control of Western Flower Thrips (Thysanoptera: Thripidae) on Sweet Pepper, Tomato, and Lettuce

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