Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246

Shiono, Yoshihito; Shimanuki, Keiko; Hiramatsu, Fuminori; Koseki, Takuya; Murayama, Tetsuya; Fujisawa, Nozomi; Kimura, Ken‐ichi

doi:10.1016/j.bmcl.2008.10.032

Cited by 51 publications

(55 citation statements)

References 8 publications

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“…GKK1032, 10 pyrrocidines A and B from LL -Cyan 426, 11 hirsutellones A–E from Hirsutella nivea BCC7579, 12 hirsutellone F from Trichoderma sp. BCC 7579, 13 pyrrospirones A and B from Neonectria ramulariae , 14 all bearing a macrocyclic ether and succinimide-derived moieties are known, it is noteworthy that only embellicines A and B from Embellisia euerka 8 have been previously reported to contain the cyclopenta[b]fluorene (6/5/6/5) ring system encountered in phomapyrrolidones A–C ( 1–3 ).…”

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confidence: 99%

Phomapyrrolidones A–C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751

Wijeratne

Franzblau

et al. 2013

J. Nat. Prod.

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Three new alkaloids, phomapyrrolidones A–C (1–3), bearing a cyclopenta[b]fluorene ring system were isolated from the mycelium extract of the endophytic fungal strain, Phoma sp. NRRL 46751, inhabiting Saurauia scaberrinae. Methylation of 1 afforded its N-methyl derivative 4. The planar structures and relative configurations of 1–4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations.

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Phomapyrrolidones A–C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751

Wijeratne

Franzblau

et al. 2013

J. Nat. Prod.

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“…Hirsutellones,[1] pyrrospirones,[2] and pyrrocidines[3] belong to a growing class of fungal secondary metabolites whose biological properties include antifungal and antibiotic activities. Particularly impressive are the activities of hirsutellones A and B ( 1a and 1b , Figure 1)[1] against Mycobacterium tuberculosis (MIC = 0.78 μg/mL), the causative pathogen of tuberculosis.…”

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Total Synthesis of Hirsutellone B

et al. 2009

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“…They were identified as Lachnum sp., Neonectriaramulariae and P. fortinii, respectively. Previously these endophytic fungi were also isolated from other plants and found to possess versatile capacities of producing biologically active compounds [17,23,24]. However, this study is the first to report the presence of these fungi in Rhodiola spp.…”

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confidence: 73%

Potential of the Endophytic Fungus Phialocephala fortinii Rac56 Found in Rhodiola Plants to Produce Salidroside and p-Tyrosol

et al. 2016

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2-(4-Hydroxyphenyl)ehyl-β-D-glucopyranoside (salidroside) and 4-(2-hydroxyethyl)phenol (p-tyrosol) are famous food and medicine additives originally derived from alpine Rhodiola plants. Salidroside or p-tyrosol production by the endophytic fungus Rac56 (Phialocephala fortinii) was confirmed by UPLC/Q-TOF-MS and 1 H-NMR. The fermentation conditions were optimized by orthogonal design using data processing system software. The broth fermentation results showed that salidroside and p-tyrosol extraction yields from Rac56 were stable and reached 1.729˘0.06 mg and 1.990˘0.05 mg per mL of culture medium, respectively. The optimal conditions for salidroside and p-tyrosol production in fermentation culture of Rac56 were determined to be 25˝C, pH values of 7 and 5, Czapek-Dox culture medium volumes of 150 mL and 50 mL in 250 mL flasks, rotation speeds of 100ˆg and 200ˆg, and fermentation durations of 7 and 15 days, respectively. Under these optimal conditions, stable yields of 2.339˘0.1093 mg and 2.002˘0.0009 mg per mL of culture medium of salidroside and p-tyrosol, respectively, were obtained, indicating that the P. fortinii Rac56 strain is a promising source of these compounds.

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Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246

Cited by 51 publications

References 8 publications

Phomapyrrolidones A–C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751

Phomapyrrolidones A–C, Antitubercular Alkaloids from the Endophytic Fungus Phoma sp. NRRL 46751

Total Synthesis of Hirsutellone B

Potential of the Endophytic Fungus Phialocephala fortinii Rac56 Found in Rhodiola Plants to Produce Salidroside and p-Tyrosol

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