QCM-nanomagnetic beads biosensor for lead ion detection

Zhang, Qingli; Cui, Haixia; Xiong, Xingliang; Wang, Ying; Shen, Jianguo; Luo, Yiting; Chen, Longcong

doi:10.1039/c7an01498h

Cited by 18 publications

(6 citation statements)

References 37 publications

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“…The linear correlation between Pb concentration logarithm and frequency changes in the proposed biosensor ranged from 0.21×10 −3 to 10.83 ppb, and the detection limit was 0.06×10 −3 ppb. 118 Other remarkable biosensors designed for lead level analysis in recent years are listed in Table 2.…”

Section: Leadmentioning

confidence: 99%

Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium

Maghsoudi¹,

Hassani²,

Mirnia³

et al. 2021

IJN

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Heavy metals cause considerable environmental pollution due to their extent and non-degradability in the environment. Analysis and trace levels of arsenic, lead, mercury, and cadmium as the most toxic heavy metals show that they can cause various hazards in humans’ health. To achieve rapid, high-sensitivity methods for analyzing ultra-trace amounts of heavy metals in different environmental and biological samples, novel biosensors have been designed with the participation of strategies applied in nanotechnology. This review attempted to investigate the novel, sensitive, efficient, cost-benefit, point of care, and user-friendly biosensors designed to detect these heavy metals based on functional mechanisms. The study’s search strategies included examining the primary databases from 2015 onwards and various keywords focusing on heavy metal biosensors’ performance and toxicity mechanisms. The use of aptamers and whole cells as two important bio-functional nanomaterials is remarkable in heavy metal diagnostic biosensors’ bioreceptor design. The application of hybridized nanomaterials containing a specific physicochemical function in the presence of a suitable transducer can improve the sensing performance to achieve an integrated detection system. Our study showed that in addition to both labeled and label-free detection strategies, a wide range of nanoparticles and nanocomposites were used to modify the biosensor surface platform in the detection of heavy metals. The detection limit and linear dynamic range as an essential characteristic of superior biosensors for the primary toxic metals are studied. Furthermore, the perspectives and challenges facing the design of heavy metal biosensors are outlined. The development of novel biosensors and the application of nanotechnology, especially in real samples, face challenges such as the capability to simultaneously detect multiple heavy metals, the interference process in complex matrices, the efficiency and stability of nanomaterials implemented in various laboratory conditions.

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Section: Leadmentioning

confidence: 99%

Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium

Maghsoudi¹,

Hassani²,

Mirnia³

et al. 2021

IJN

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“…61 A similar strategy has been used with embedded magnetic nanoparticles. 62 Other approaches involve biocatalytic precipitation to deposit insoluble products onto the sensor surface and enzymatic chain reactions to amplify or reduce the detected signal. [63][64][65][66][67][68] Chain reactions involving DNA amplifications, hybridization, and displacement have proven to lower the limit of detection significantly for nucleic acid based biosensors.…”

Section: The Role Of Qcm-d In Biosensingmentioning

confidence: 99%

Recent applications of QCM-D for the design, synthesis, and characterization of bioactive materials

Mosley

Talarico

Byrne

2021

Journal of Bioactive and Compatible Polymers

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The clinical translation of bioactive technologies is lacking compared to the number of novel technologies reported in the literature. This is in part due to the difficulties in characterizing bioactive materials to understand and predict their biological response. To progress the field and increase clinical success, more robust analytical techniques must be utilized when investigating novel bioactive materials. The quartz crystal microbalance with dissipation (QCM-D), a label-free sensing instrument based on an acoustic resonator, is used to quantify mass change and viscoelastic parameters from soft materials at the nanoscale, in situ, with precise temporal resolution and operation in both liquid and gaseous environments. The versatility of QCM-D has enhanced the characterization of bioactive polymers and sensing arrays for advanced applications of novel biotechnologies. In this review, we highlight exciting, recent applications of QCM-D for the investigation of bioactive materials. Attention is given to the dynamic mechanical properties of bioactive materials, discerning protein structure on surfaces, probing cell adhesion and cytoskeletal changes, and biosensing applications. We conclude that QCM-D has untapped utility in the pre-clinical investigation of bioactive materials and further utilization can improve the clinical success of novel technologies.

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“…Quartz crystal microbalances (QCMs) have gained increasing popularity in various fields, such as chemistry [1,2,3,4,5], biomedicine [6,7,8,9,10], and environmental fields [11,12,13,14], due to high sensitivity, simple operation principles, a digital output, and low-cost components.…”

Section: Introductionmentioning

confidence: 99%

Investigation on Mass Sensitivity of N-M Type Electrode Quartz Crystal Microbalance

Chen

Huang

Pan

et al. 2019

Sensors

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Mass sensitivity plays a crucial role in the practical application of quartz crystal microbalances (QCMs)-based quantitative analysis. n-m type QCMs have many applications, so it is necessary to clarify the relationship between the mass sensitivity and the electrode of the n-m type QCM. The performance of gold-plated films with different electrodes was studied by theoretical calculation and experiment. The results show that the mass sensitivity on the surface of the n electrode and the surface of the m electrode are essentially the same. Meanwhile, the mass sensitivity of n-m type QCMs varies with the diameter of the n and m electrodes. When the diameter of the n electrode is close to half the diameter of the m electrode, mass sensitivity is at maximum value. These results are important for the further designs and applications of n-m type QCMs.

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QCM-nanomagnetic beads biosensor for lead ion detection

Abstract: A QCM biosensor combined with NMBs has been proposed for Pb2+detection with a lower detection limit of 0.3 pM.

Cited by 18 publications

References 37 publications

Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium

Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium

Recent applications of QCM-D for the design, synthesis, and characterization of bioactive materials

Investigation on Mass Sensitivity of N-M Type Electrode Quartz Crystal Microbalance

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