Qi deficiency is associated with depression in chronic hemodialysis patients

Liao, Yuan; Chang, Chiz Tzung; Li, Tsai‐Chung; Sun, Mao; Chang, Hen Hong; Tsai, Fuu Jen; Yen, Hung-Rong

doi:10.1016/j.ctim.2016.12.008

Cited by 13 publications

(8 citation statements)

References 37 publications

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“…Third, serotonin and histamine are common mediators of inflammation, and tryptophan and histidine are important precursors for serotonin and histamine ( Alfaifi et al, 2020 ). Particularly, in the theory of TCM, the abnormal rise and fall of qi can lead to a series of clinical manifestations, such as depression ( Liao et al, 2017 ) and insomnia ( Ye et al, 2015 ; Li et al, 2020 ), while the traditional use of ZYP on digestive system diseases is achieved by regulating qi . Coincidentally, the two main products in the tryptophan metabolic pathway, 5-HT and melatonin, are representative drugs for depression and insomnia ( Cardinali et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Mechanism of interventional effect and targets of Zhuyu pill in regulating and suppressing colitis and cholestasis

Zhang

Wen

et al. 2022

Front. Pharmacol.

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Zhuyu pill (ZYP) is a traditional Chinese medicine prescription composed of two drugs, Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, and is commonly used in the clinical treatment of diseases of the digestive system. However, the mechanism underlying the effect of ZYP on colitis remains unclear. In this study, a colitis rat model was induced with 2,4,6-trinitro-benzenesulfonic acid (TNBS, 100 mg/kg) and treated with ZYP (low dose: 0.6 g/kg, high dose: 1.2 g/kg). Disease activity index, colonic weight index, and weight change ratio were used to evaluate the model and efficacy. LC-MS and 16S rRNA gene sequencing were used to measure differences in fecal metabolism and microorganism population among the control, model, low-dose ZYP, and high-dose ZYP groups. To elucidate the mechanism of interventional effect of ZYP, Spearman correlation analysis was used to analyze the correlation between fecal metabolism and fecal microbial number. High-dose and low-dose ZYP both exhibited significant interventional effects on colitis rat models, and high-dose ZYP produced a better interventional effect compared with low-dose ZYP. Based on a metabolomics test of fecal samples, significantly altered metabolites in the model and high-dose ZYP treatment groups were identified. In total, 492 metabolites were differentially expressed. Additionally, sequencing of the 16S rRNA gene in fecal samples revealed that the high-dose ZYP could improve TNBS-induced fecal microbiota dysbiosis. Ultimately, changes in tryptophan metabolism and Firmicutes and Gammaproteobacteria populations were detected after ZYP treatment in both colitis and cholestasis. Therefore, we conclude that tryptophan metabolism and Firmicutes and Gammaproteobacteria populations are the core targets of the anti-inflammatory effect of ZYP. These findings provide a scientific basis for further investigation of the anti-inflammatory mechanism of ZYP in the future.

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Section: Discussionmentioning

confidence: 99%

Mechanism of interventional effect and targets of Zhuyu pill in regulating and suppressing colitis and cholestasis

Zhang

Wen

et al. 2022

Front. Pharmacol.

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“…Qi-de ciency and depression can accumulate heart/liver to cause re, as well as impaired Yin-consume the body uid then leading to Yang heat diathesis or Yin de ciency diathesis. Qi stagnation can produce the blood-stasis constitution [40,41]. Thus, Good mental status, conscious activities, and stable emotion are bene cial to the health, ensuing to prevent the disorder of qi movement that helps to avoid unbalanced TCMC types' occurrence.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal studies on the characteristics of TCM constitutions and related factors of adult Chinese women in Hong Kong

Sun

Chan

et al. 2021

Preprint

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Background Traditional Chinese Medicine Constitution (TCMC, Named Tizhi in Chinese) is essential to reflect an individual’s body-mind and health. Understanding TCMCs and their influencing factors would be beneficial for improving the individual’s health and disease prevention. Earlier our studies have found the characteristics of TCMCs and related influencing factors at a single time point, however, longitudinal data on the development of characteristics of TCMC constitutions over time is limited. Hence, this follow-up study was attempted to investigate the changes in characteristics of TCMCs and explore the factors influencing the development of individual TCMC types at baseline and follow-up. Materials and methods We conducted a follow-up cross-sectional survey of Chinese women in Hong Kong to compare with the characteristics of TCMCs as well as influencing factors related to each TCMC type at baseline with a 4-year interval by using the questionnaires with slight modifications. Statistical methods were employed as similar to that of the initial study including students’ T-test, Chi-square test one way ANOVA, multiple stepwise logistic regression analysis, and association rules mining method. Results A response rate of 59.0% was achieved in the follow-up study. Of 81.5% among 249 participants were diagnosed with unbalanced TCMCs. Qi-deficiency constitution (QDF, 51.8%), Yang-deficiency (PD, 45.4%), and Phlegm-wetness (PW, 38.6%) were still the top three unbalanced TCMCs types and the Yin-deficiency (ND), Blood stasis (BS) and Qi-depressed (QDP) constitutions were significantly increasing. The percentage of owning 1 to 2 unbalanced TCMC types by individual decreased from 30.9% at baseline to 26.9% at follow-up, whereas having 3–6 unbalanced TCMC types had increased from 47.4% at baseline to 58.2% at follow-up. Results of the association mining rules showed the top three paired-unbalanced TCMC types were in QDP paired with QDF (93.75%), PW paired with QDF (85.42%), and PD paired with QDF (81.65%) respectively. Stepwise logistic analysis indicated that poorer health condition (OR, 1.37–2.56), suffering negative effect on body-mind health (OR, 2.70–4.06), negative emotion (OR = 2.57) was significantly positively correlated with certain unbalanced TCMCs. Aging (OR, 0.91–0.93), regular exercise (OR = 0.71) usage of TCM habit (OR = 0.12), and women who experienced menopause (OR, 0.37–0.39) showed inverse correlations with certain unbalanced constitutions. Conclusion Owned unbalanced and more complex TCMC types were the main characteristics of TCMCs in most adult Chinese women in Hong Kong with a 4 -year interval during follow-up. QDF, PD, and PW constitutions were still the top three frequent unbalanced TCMC types at baseline and follow-up, but ND, BS, and QDP constitutions significantly increased during the menopausal stage. Poor health status, unhappy emotions, and/or suffering negative effects on body-mind health and suffering in the menopause stage may be the diverse factors for the development of unbalanced TCMC types, however, regular exercise and habit of regular usage of TCM might be potential protectors for maintaining in the normal constitution.

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“…Our findings also confirmed that frequent emotional fluctuation could harm body-mind health, likely resulting in a QDP with high frequency paired with a QDF owned by the individual. Qi stagnation can produce BS [31,32]. Thus, Good mental status, conscious activities, and stable emotions are beneficial to the health, ensuing to prevent the disorder of qi movement that helps to avoid unbalanced TCMC types of occurrences.…”

Section: Influencing Factors Related To Unbalanced Tcmc Types and The...mentioning

confidence: 99%

Longitudinal Studies on the Characteristics of TCM Constitutions and Related Factors of Women in Hong Kong

Guo¹,

He²,

Y³

et al. 2022

Pharmacophore

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Traditional Chinese Medicine Constitution (TCMC) is essential to reflect an individual's bodymind and health. Understanding TCMCs and their influencing factors would benefit the individual's health and disease prevention. Our previous cross-sectional studies have found the characteristics of TCMCs and related influencing factors simultaneously. However, longitudinal data on the development of characteristics of TCMC constitutions over time is limited. This follow-up study attempted to investigate the changes in characteristics of TCMCs and explore the factors influencing the development of individual TCMC types at baseline and follow-up. We conducted a follow-up survey of Chinese women in Hong Kong to compare the characteristics of TCMCs and their factors at baseline with a 4-year interval. Of 81.5% among 249 participants were diagnosed with unbalanced TCMCs. Most of the constitutions were significantly increasing. Stepwise logistic analysis indicated that poorer health conditions (OR=1.37-2.56), negative effect on body-mind health (OR, 2.70-4.06), and negative emotion (OR, 2.57) were positively correlated with certain unbalanced TCMCs. Aging (OR, 0.91-0.93), regular exercise (OR=0.71), usage of TCM habits (OR=0.12), and menopause (OR, 0.37-0.39) showed inverse correlations with certain unbalanced constitutions. Based on the findings, we concluded that diverse factors could unbalance TCMC. At the same time, regular exercise and habit of regular usage of TCM might be potential protectors to regulate the normal constitution.

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Qi deficiency is associated with depression in chronic hemodialysis patients

Cited by 13 publications

References 37 publications

Mechanism of interventional effect and targets of Zhuyu pill in regulating and suppressing colitis and cholestasis

Mechanism of interventional effect and targets of Zhuyu pill in regulating and suppressing colitis and cholestasis

Longitudinal studies on the characteristics of TCM constitutions and related factors of adult Chinese women in Hong Kong

Longitudinal Studies on the Characteristics of TCM Constitutions and Related Factors of Women in Hong Kong

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