Qingda granule alleviate angiotensin ⅱ-induced hypertensive renal injury by suppressing oxidative stress and inﬂammation through NOX1 and NF-κB pathways

Chen, Daxin; Long, Linzi; Lin, Shan; Jia, Peizhi; Zhu, Zhengchuan; Gao, Huajian; Wang, Tianyi; Zhu, Ying; Shen, Aling; Chu, Jianfeng; Lin, Wei; Peng, Jun; Chen, Ke-ji

doi:10.1016/j.biopha.2022.113407

Cited by 9 publications

(5 citation statements)

References 36 publications

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“…Qian Yang Yu Yin Granule has been found to relieve hypertensive renal injury through multiple mechanisms, including a nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase (NOX)-reactive oxygen species (ROS) pathway [ 73 ], a novel epigenetic mechanism related to Nicotinamide N-Methyltransferase expression, and reversing the Ang II-induced autophagy of podocytes [ 74 ]. Qingda granule [ 75 ] has been shown to improve renal function through inhibition of NF-κB signaling pathway and inflammation. Tengdan capsule (TDC) [ 76 ] could effectively lower blood pressure and protect against renal damage by regulating the TGF-β/Smad signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Current perspectives and trends of the research on hypertensive nephropathy: a bibliometric analysis from 2000 to 2023

Wang,

Zhang

et al. 2024

Renal Failure

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Hypertensive nephropathy continues to be a major cause of end-stage renal disease and poses a significant global health burden. Despite the staggering development of research in hypertensive nephropathy, scientists and clinicians can only seek out useful information through articles and reviews, it remains a hurdle for them to quickly track the trend in this field. This study uses the bibliometric method to identify the evolutionary development and recent hotspots of hypertensive nephropathy. The Web of Science Core Collection database was used to extract publications on hypertensive nephropathy from January 2000 to November 2023. CiteSpace was used to capture the patterns and trends from multi-perspectives, including countries/regions, institutions, keywords, and references. In total, 557 publications on hypertensive nephropathy were eligible for inclusion. China ( n = 208, 37.34%) was the most influential contributor among all the countries. Veterans Health Administration ( n = 19, 3.41%) was found to be the most productive institution. Keyword bursting till now are renal fibrosis, outcomes, and mechanisms which are predicted to be the potential frontiers and hotspots in the future. The top seven references were listed, and their burst strength was shown. A comprehensive overview of the current status and research frontiers of hypertensive nephropathy has been provided through the bibliometric perspective. Recent advancements and challenges in hypertensive nephropathy have been discussed. These findings can offer informative instructions for researchers and scholars.

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Section: Discussionmentioning

confidence: 99%

Current perspectives and trends of the research on hypertensive nephropathy: a bibliometric analysis from 2000 to 2023

Wang,

Zhang

et al. 2024

Renal Failure

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“…NF-kB has been recognized as a key target for disease treatment. [47][48][49] Several anti-inflammatory drugs have been proved to inhibit the activation of NF-kB by blocking the degradation of I-kBα, such as aspirin, [50] sodium salicylate [51] and dexamethasone. [52] In our study, dendrocandin U obviously decreased the expression of TLR4 and MyD88 and inhibited the phosphorylation levels of I-kBα and NF-kB p65 at 20 μM (Figure 6).…”

Section: Discussionmentioning

confidence: 99%

“…It is involved in the regulation of multiple diseases, such as inflammatory diseases, autoimmune diseases and allergic diseases. NF‐κB has been recognized as a key target for disease treatment [47–49] . Several anti‐inflammatory drugs have been proved to inhibit the activation of NF‐κB by blocking the degradation of I‐κBα, such as aspirin, [50] sodium salicylate [51] and dexamethasone [52] .…”

Section: Discussionmentioning

confidence: 99%

Dendrocandin U fromDendrobium officinaleKimura et Migo Inhibits M1 Polarization in Alveolar Macrophage by Suppressing NF‐κB Signaling Pathway

Piao,

Feng,

Zhao

et al. 2023

Chemistry & Biodiversity

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Dendrobium officinale Kimura et Migo is a valuable and homologous medicine and food traditional Chinese medicine. Currently there are few studies on the anti‐inflammatory activity of lipophilic components. The aim of this study was to explore the anti‐inflammatory effect and mechanism of the lipophilic compounds in Dendrobium officinale. Six compounds were isolated and identified, including three bibenzyl compounds, dendrocandin U, dendronbibisline B, erianin, and three lignans, (−)‐syringaresinol, (+)‐syringaresinol‐O‐β‐D‐glucopyranoside, 5‐methoxy‐(+)‐isolariciresinol. Among them, dendronbibisline B and 5‐methoxy‐(+)‐isolariciresinol were isolated from Dendrobium officinale for the first time. Besides, we found dendrocandin U, dendronbibisline B and (−)‐syringaresinol exhibited the anti‐inflammation to inhibit nitric oxide secretion induced by lipopolysaccharide (LPS)/interferon (IFN‐γ) in MH−S cells. Furthermore, dendrocandin U could inhibit the expression of tumor necrosis factor‐α (TNF‐α), Cluster of Differentiation 86 (CD86), and reduce inflammatory morphological changes of macrophages. Meanwhile, we confirmed that the anti‐inflammation mechanism of dendrocandin U was to inhibit M1 polarization by suppressing toll‐like receptor 4 (TLR4)/recombinant myeloid differentiation factor 88 (MyD88)/nuclear factor kappa B (NF‐κB) signaling pathway. In this paper, dendrocandin U with significant anti‐inflammatory activity was found from Dendrobium officinale, which could provide a basis for the study of its anti‐inflammatory drugs.

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“…23,24 In spontaneously hypertensive rats (SHRs), quercetin reduces pulse rate, minimizes endothelial dysfunction and pathogenesis of morphological characteristics. 25,26 However, the precise impact of quercetin as an anti-hypertensive agent on vascular smooth muscles requires further investigation. Therefore, our current study explored the efficacy of quercetin on blood pressure, pulse wave velocity (PWV), and pathological alterations in abdominal aorta of mice infused with Ang II.…”

Section: Introductionmentioning

confidence: 99%

“…It also has preventive and protective activities against inflammation, viral infections, nervous system protection, heart disease, and cancer 23,24 . In spontaneously hypertensive rats (SHRs), quercetin reduces pulse rate, minimizes endothelial dysfunction and pathogenesis of morphological characteristics 25,26 . However, the precise impact of quercetin as an anti‐hypertensive agent on vascular smooth muscles requires further investigation.…”

Section: Introductionmentioning

confidence: 99%

Quercetin attenuates angiotensin II‐induced proliferation of vascular smooth muscle cells and p53 pathway activation in vitro and in vivo

et al. 2023

Self Cite

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Quercetin is an essential flavonoid mostly found in herbal plants, fruits, and vegetables, which exhibits anti‐hypertension properties. However, its pharmacological impact on angiotensin II (Ang II) induced the increase of blood pressure along with in‐depth mechanism needs further exploration. The present study pointed out the anti‐hypertensive role of quercetin and its comprehensive fundamental mechanisms. Our data showed that quercetin treatment substantially reduced the increase in blood pressure, pulse wave velocity, and aortic thickness of abdominal aorta in Ang II‐infused C57BL/6 mice. RNA sequencing revealed that quercetin treatment reversed 464 differentially expressed transcripts in the abdominal aorta of Ang II‐infused mice. Moreover, overlapping KEGG‐enriched signaling pathways identified multiple common pathways between the comparison of Ang II versus control and Ang II + quercetin versus Ang II. Likewise, these pathways included cell cycle as well as p53 pathways. Transcriptome was further validated by immunohistochemistry, indicating that quercetin treatment significantly decreased the Ang II‐induced expression of proliferating cell nuclear antigen (PCNA), cyclin‐dependent kinase‐4 (CDK4), and cyclin D1, while increased protein expression of p53, and p21 in abdominal aortic tissues of mice. In vitro, quercetin treatment meaningfully decreased the cell viability, arrested cell cycle at G0/G1 phase, and up‐regulated the p53 and p21 proteins expression, as well as down‐regulated the protein expression of cell cycle‐related markers, for example, CDK4, cyclin D1 in Ang II stimulated vascular smooth muscle cells (VSMCs). This study addresses pharmacologic and mechanistic perspectives of quercetin against Ang‐II‐induced vascular injury and the increase of blood pressure.

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Qingda granule alleviate angiotensin ⅱ-induced hypertensive renal injury by suppressing oxidative stress and inﬂammation through NOX1 and NF-κB pathways

Cited by 9 publications

References 36 publications

Current perspectives and trends of the research on hypertensive nephropathy: a bibliometric analysis from 2000 to 2023

Current perspectives and trends of the research on hypertensive nephropathy: a bibliometric analysis from 2000 to 2023

Dendrocandin U fromDendrobium officinaleKimura et Migo Inhibits M1 Polarization in Alveolar Macrophage by Suppressing NF‐κB Signaling Pathway

Quercetin attenuates angiotensin II‐induced proliferation of vascular smooth muscle cells and p53 pathway activation in vitro and in vivo

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