“…Cochrane Database of Systematic Reviews Index tests were interpreted without the knowledge of the reference standard in 72 (94%) studies, and with the knowledge of the reference standard in four studies due to: the same assessor applying/conducting the index test and reference standard (Rathore 2012), the index test being interpreted with knowledge of the reference standard (Lazarchik 1995), the index test preceding the reference standard (Matos 2011;Mortensen 2018). A prespecified threshold for interpretation of the index test was used in 74 (96%) studies.…”