QT Interval and Dispersion in Very Young Children Treated with Antipsychotic Drugs: A Retrospective Chart Review

Nahshoni, Eitan; Spitzer, Sara; Berant, Michael; Shoval, Gal; Zalsman, Gil; Weizman, Abraham

doi:10.1089/cap.2007.0061

Cited by 19 publications

(4 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study showed that abnormal QT dispersion or T wave abnormalities were not significantly associated with antipsychotic treatment, but were associated with lithium therapy [33]. In another study conducted by Nahshoni et al [34], QT interval, QTd, and rate-corrected values were calculated before initiation of antipsychotic treatment and during the maintenance period of 12 children while 3 of them were concomitantly maintained on methylphenidate therapy. They found that QT interval, QTd, and their rate-corrected values were all within normal values both before and after successful drug treatment.…”

Section: Discussionmentioning

confidence: 98%

QT dispersion and P wave dispersion in schizophrenia

Baykara

Yılmaz

Baykara

2018

Psychiatry and Clinical Psychopharmacology

View full text Add to dashboard Cite

BACKGROUND: The difference between maximum QT (QTmax) and minimum (QTmin) on electrocardiography (ECG) is known as QT dispersion (QTd). An increase in QTd carries the risk of ventricular arrhythmia and subsequent death. P wave dispersion (Pd) shows the difference between maximum P (Pmax) and minimum P (Pmin). Prolonged P wave duration and an increase in Pd are a risk for irregular electrical transmission and atrial fibrillation. OBJECTIVES: The aim of this study was to examine QTd and Pd values which indicate atrial fibrillation and ventricular arrhythmia in schizophrenia patients with whom cardiovascular diseases (CVD) are seen at a higher rate than the general population.

show abstract

Section: Discussionmentioning

confidence: 98%

QT dispersion and P wave dispersion in schizophrenia

Baykara

Yılmaz

Baykara

2018

Psychiatry and Clinical Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…36 In one study, it was determined that QTd and T-wave abnormalities were related with mood regulators, not with antipsychotic treatment. 37 In our results, none of the patients had mood-regulating drug use. They had left their antipsychotic treatment at least 1 month ago, and the treatment that was used was atypical antipsychotic treatment.…”

Section: Discussionmentioning

confidence: 44%

Electrocardiographic evaluation of the ventricular arrhythmia risk in patients with schizophrenia

Özsoy¹,

Zorlu²,

Kaya³

2021

Anadolu Psikiyatri Derg

View full text Add to dashboard Cite

Objective The purpose of this study was to examine electrocardiographic ventricular arrhythmia predictors in patients with schizophrenia by comparing with healthy controls. Methods The study included 100 patients with schizophrenia and 100 healthy controls. Electrocardiography (ECG) was performed on all participants in resting position. T-wave peak to end (Tp-e), QT ranges, P-wave dispersion (Pd), and R-R range were measured. Then, the Schizophrenia Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS) were applied to the schizophrenia group. Results The PANSS positive symptom subscale was calculated as 10.41 (SD = 2.27), the negative symptom subscale was calculated as 14.44 (SD = 5.42), and the overall functionality level was calculated as 27.04 (SD = 5.43). The mean CDSS score was determined to be 3.74 (SD = 2.15). No differences were detected in the heart rate measurements of the patient and control groups in ECG results ( P = .427). The minimum QT interval and minimum Tp-e wave times were found to be low in the patient group ( P < .001 for both intervals). Corrected QTc dispersion, Pd, Tp-e dispersion, and QT dispersion were found to be higher in the patient group than in healthy controls ( P < .001 for all intervals). Discussion Based on our results, it is possible to speculate that patients with schizophrenia are at a risk of developing cardiac arrhythmia and cardiac dysfunction if they do not receive treatment. For this reason, clinicians should pay attention to cardiac transmission problems when organizing the treatment of patients. Further studies should be conducted to determine cardiac problems in patients with schizophrenia.

show abstract

“…According to a previous report, the QTc interval was not changed with psychostimulant drugs like risperidone and clotiapine 18 . Similarly, recent reports investigating the effects of methylphenidate on the QTc interval showed a mild increase in heart rate and blood pressure, but no effect on the QTc interval [19][20][21] .…”

Section: Discussionmentioning

confidence: 97%