Quadrantal macular retinal thickness changes in strabismus subjects with abnormal binocular vision development

Oka, Mayumi; Yamashita, Tsutomu; Ono, Shizuka; Kubo, Ikumi; Tabuchi, Akio

doi:10.1007/s10384-012-0214-8

Cited by 5 publications

(10 citation statements)

References 24 publications

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“…Unlike other studies, Oka et al. [10] reported that the dominant eyes of patients with strabismus who had developed abnormal binocular vision had thinner superior temporal quadrantal macular thickness values.…”

Section: Discussionmentioning

confidence: 84%

“…This study was motivated by recent reports revealing interocular quadrant macular thickness, refractive error, and axial length differences in sighting ocular dominance [10,11]. Because the macula is the retinal area concerned with central vision and is the primary determinant of visual output to the visual cortex, we hypothesized that it might complement the brain's primary role in the mechanism of ocular dominance.…”

Section: Introductionmentioning

confidence: 99%

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Macular asymmetry analysis in sighting ocular dominance

Pekel

Acer

Özbakış

et al. 2014

The Kaohsiung J of Med Scie

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Sighting ocular dominance is the preference of one eye over the other in terms of sighting. In this study, our aim was to examine differences in interocular and intraocular macular thickness, interocular fovea-optic disc angle, and foveal blood vessel asymmetries associated with sighting ocular dominance. Ninety eyes of 45 healthy young adults were included in this prospective, cross-sectional, and comparative study. Sighting ocular dominance was determined by a hole-in-the-card test. Macular thickness measurements were taken and posterior pole asymmetry analysis conducted with spectral domain optical coherence tomography. The optic disc-fovea angle and visible foveal blood vessel counts were calculated by using the posterior pole retinal images of optical coherence tomography. The mean age of the participants was 27.3 (standard deviation [SD] 6.6) years. There were 20 males and 25 females. The mean total macular area thickness, and mean macular thickness of the superior and inferior hemispheres of the dominant and nondominant eyes were similar (p > 0.05). Macular asymmetry analysis revealed no statistically significant interocular difference (p > 0.05). In the dominant eyes, the mean optic disc-fovea angle was 5.24° (SD 1.77), whereas it was 5.49° (SD 2.58) in the nondominant eyes (p = 0.51). The number of visible blood vessels passing through the fovea was similar in the dominant and nondominant eyes (p > 0.05). These results suggested that interocular and intraocular macular thickness differences, interocular fovea-optic disc angle differences, and number of visible foveal blood vessels are not associated with sighting ocular dominance.

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Macular asymmetry analysis in sighting ocular dominance

Pekel

Acer

Özbakış

et al. 2014

The Kaohsiung J of Med Scie

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“…This phenomenon can cause suppression or potentially abnormal retinal correspondence [ 7 – 11 ]. In reports of strabismic patients with abnormal binocular vision development, OCT exhibited changes in macular retinal thickness [ 1 ]. Retinal thickness was correlated with retinal perfusion for both healthy subjects and amblyopia [ 3 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previously, concomitant strabismic patients with normal visual acuity were generally considered to have normal macular structure. However, recent studies have revealed morphological changes in the macular of strabismic patients, including thickened outer retinal layers in XT patients according to optical coherence tomography (OCT) [ 1 , 2 ]. Furthermore, known relationships exist between retinal thickness and retinal perfusion in healthy subjects [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Macular perfusion density evaluation in constant and intermittent exotropia by means of optical coherence tomography angiography

Zhai

Fang

et al. 2021

BMC Ophthalmol

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Background To quantify and compare retinal microvascular features using optical coherence tomography angiography (OCTA) in constant (XT) and intermittent exotropia (IXT). Methods An observational cross-sectional study was conducted from September 2020 to November 2020 at the Affiliated Eye Hospital of Wenzhou Medical University. OCTA examination was performed to evaluate the macular perfusion density of the deep capillary plexus (DCP), superficial capillary plexus (SCP), and foveal avascular zone (FAZ) parameters in XT and IXT patients, and in age-matched controls. The study parameters were analyzed. Results A total of 76 participants, including 16 (21%) XT patients, 24 (32%) IXT patients, and 36 (47%) controls, were recruited. The exodeviation angle was 39.06 ± 10.38 prism degrees (PD) at near and 43.00 ± 9.74 PD at distance in the XT group, and 27.13 ± 18.28 PD at near and 31.04 ± 18.82 PD at distance in the IXT group. The macular perfusion density of the DCP in 6 × 6-mm scans and the SCP in 3 × 3-mm scans were lower in the deviating eyes than in the fixating eyes of XT patients (p < 0.001, p = 0.032, respectively). The macular perfusion density of the DCP in the deviating eyes of XT and IXT patients was significantly lower than that of the controls. There was no significant difference in the FAZ parameters among the groups. Conclusions In XT patients, OCTA revealed lower macular perfusion density in deviating eyes than in fixating eyes and control eyes. IXT patients showed no difference between the two eyes, but the macular perfusion density of the DCP was lower than that of the controls.

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“…(10)(11)(12)(13) Several studies have demonstrated that inconsistent macular structure changes in the deviated eye in strabismus, which includes increased central macular thickness postoperatively and decreased total macular thickness of the dominant eye, although these pathoanatomical ndings have not been con rmed. (14,15) However, macular OCTA ndings in large angle exotropia with abnormal binocular vision have not been reported. The study aimed to use OCTA to assess macular microvasculature and the foveal avascular zone (FAZ) in large exodeviation patients with abnormal binocular vision.…”

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confidence: 99%

Evaluation of retinal microvasculature in exotropia with abnormal binocular vision by optical coherence tomography angiography

Chen

Zhu

et al. 2022

Preprint

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Background: To explore the retinal microvasculature in large angle concomitant exotropia patients with abnormal binocular vision using quantitative optical coherence tomography angiography (OCTA) analysis. Methods: OCTA images of 52 healthy and 100 strabismic eyes were analyzed to quantify the retinal thickness (RT), superficial capillary plexus (SCP), deep capillary plexus (DCP), and foveal avascular zone (FAZ). Paired t-tests were performed comparing differences in the two groups, dominant and deviated eyes in exotropia group, respectively. Results: The mean angle of deviation at the distance was 79.38 [± 25.64] (prism diopters, PD). The temporal SCP in exotropia group was significantly higher than that of control group in deviated eyes (p = 0.020). Nasal vessel density in exotropia group was lower than that of control group in the SCP in deviated eyes (p = 0.037). There were significantly differences in the DCP in deviated eyes between exotropia group and control group (Fovea: p = 0.007; Temporal: p = 0.014; Nasal: p = 0.028; Inferior: p = 0.013). Dominant eyes had significantly greater nasal RT and temporal SCP than deviated eyes (p = 0.023 and p = 0.043). Conclusions:The study found that OCTA reveals subnormal, superficial, and deep macular capillary density in large angle exotropia patients with abnormal binocularity and may be related to retinal suppression. Changes in macular microvasculature may offer valuable insights in the development of strabismus. Further studies are needed to determine the clinical relevance of this finding. Trial registration: This trial is registered as ChiCTR2100052577 at www.Chictr.org.cn .

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Quadrantal macular retinal thickness changes in strabismus subjects with abnormal binocular vision development

Cited by 5 publications

References 24 publications

Macular asymmetry analysis in sighting ocular dominance

Macular asymmetry analysis in sighting ocular dominance

Macular perfusion density evaluation in constant and intermittent exotropia by means of optical coherence tomography angiography

Evaluation of retinal microvasculature in exotropia with abnormal binocular vision by optical coherence tomography angiography

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