Quadriceps strength and endurance in fibrotic idiopathic interstitial pneumonia

Mendoza, Laura; Gogali, Athena; Shrikrishna, Dinesh; Cavada, Gabriel; Kemp, Samuel V.; Natanek, Samantha A.; Jackson, A D; Polkey, Michael I.; Wells, Adrian; Hopkinson, Nicholas S

doi:10.1111/resp.12181

Cited by 47 publications

(49 citation statements)

References 37 publications

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“…In a study by NISHIYAMA et al [50], the quadriceps muscle force of 41 IPF patients studied retrospectively was reduced on average to 65% predicted and represented an independent predictor of V′O 2 peak at the end of exercise. A more recent prospective study showed reduced quadriceps strength and endurance in IPF and nonspecific interstitial pneumonia patients, compared to age-matched controls [51]. A similar relationship between quadriceps peak torque and both peak workload and functional exercise capacity has been documented in patients with sarcoidosis [52].…”

Section: Peripheral Muscle Dysfunctionmentioning

confidence: 73%

Exertional dyspnoea in interstitial lung diseases: the clinical utility of cardiopulmonary exercise testing

Bonini

Fiorenzano

2017

Eur Respir Rev

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Interstitial lung diseases (ILDs) represent a heterogeneous group of pathologies characterised by alveolar and interstitial damage, pulmonary inflammation (usually associated with fibrosis), decreased lung function and impaired gas exchange, which can be attributed to either a known or an unknown aetiology. Dyspnoea is one of the most common and disabling symptoms in patients with ILD, significantly impacting quality of life. The mechanisms causing dyspnoea are complex and not yet fully understood. However, it is recognised that dyspnoea occurs when there is an imbalance between the central respiratory efferent drive and the response of the respiratory musculature. The respiratory derangement observed in ILD patients at rest is even more evident during exercise. Pathophysiological mechanisms responsible for exertional dyspnoea and reduced exercise tolerance include altered respiratory mechanics, impaired gas exchange, cardiovascular abnormalities and peripheral muscle dysfunction.This review describes the respiratory physiology of ILD, both at rest and during exercise, and aims to provide comprehensive and updated evidence on the clinical utility of the cardiopulmonary exercise test in the assessment and management of these pathological entities. In addition, the role of exercise training and pulmonary rehabilitation programmes in the ILD population is addressed.

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Section: Peripheral Muscle Dysfunctionmentioning

confidence: 73%

Exertional dyspnoea in interstitial lung diseases: the clinical utility of cardiopulmonary exercise testing

Bonini

Fiorenzano

2017

Eur Respir Rev

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“…Reduced quadricep strength and endurance was seen in patients with fibrotic idiopathic interstitial pneumonias relative to healthy controls [Mendoza et al 2014]. However, there was no association between 6MWD and quadricep force [Mendoza et al 2014].…”

Section: Muscle Dysfunctionmentioning

confidence: 99%

Current best practice in rehabilitation in interstitial lung disease

Nakazawa

Cox

Holland

2016

Ther Adv Respir Dis

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Abstract:Interstitial lung disease (ILD) is a group of chronic respiratory diseases characterized by dyspnoea on exertion and decline in health-related quality of life (HRQL). People with ILD experience significant exercise limitation with contributors that include ventilatory limitation, impaired gas exchange, decreased cardiac function and skeletal muscle dysfunction. Pulmonary rehabilitation (PR) is well established in patients with chronic obstructive pulmonary disease (COPD) as a means to overcome exercise limitation and improve activity-related dyspnoea. There is increasing evidence for similar effects of PR in people with ILD. This review discusses the evidence for PR in ILD, outlines the essential components of PR in this population, and highlights special considerations for exercise training in people with ILD. Possible future directions for PR research in people with ILD are explored.

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“…There are similarities and differences in peripheral muscle dysfunction between ILD and COPD. Studies in both populations report reduced voluntary strength of the quadriceps as the most common finding of peripheral muscle function; preferential muscle weakness in the lower versus upper extremities; and have a smaller body of evidence of reduced non-volitional quadriceps strength and endurance [3,18,35,37].…”

Section: Discussionmentioning

confidence: 99%

“…One study did not find reductions in volitional quadriceps muscle strength compared to healthy controls, however did report reduced non-volitional quadriceps muscle strength and endurance. [37] Quadriceps force or torque was reduced to a greater extent than handgrip force, which was reported to be normal in some studies, or marginally reduced (range: 84-97% predicted). Muscle strength and lower extremity function was also measured using short functional tests targeting muscle strength (3 studies); and lower performance in individuals with ILD compared to healthy controls or predicted values was reported.…”

Section: Findings Of Muscle Strength and Endurancementioning

confidence: 99%

“…Fat free mass and fat free mass index measured using bioelectrical impedance analysis was reported as either normal 34 or impaired [37]. A smaller mid-thigh cross-sectional area using computerized tomography and ultrasound imaging, and reduced rectus femoris cross sectional area, calf and bicep muscle layer thickness using ultrasound imaging was observed in ILD compared to healthy controls [35,36,48].…”

Section: Alterations In Peripheral Muscle Structure and Metabolic Chamentioning

confidence: 99%

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Peripheral Muscle Dysfunction in Interstitial Lung Disease: A Scoping Study

Wickerson¹,

Brooks²,

Mathur³

2016

Physiother Rehabil

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Purpose: To characterize the state of the evidence for peripheral muscle dysfunction in individuals with interstitial lung disease (ILD). Method:A scoping study was performed by searching multiple electronic databases for published papers and conference abstracts of any study design that included a measure of peripheral muscle dysfunction and/or structural and metabolic characteristics of muscle. All sub-types of ILD were eligible. Result:Forty-five studies representing 2522 individuals with 34 sub-types of ILD were included in this study. Data were charted using descriptive numerical analysis of study characteristics. Peripheral muscle dysfunction was predominantly reflected by reduced volitional isometric strength (17 studies), whereas the evaluation of muscle endurance was rare (2 studies). Volitional muscle force or torque was measured in the quadriceps (14 studies) and handgrip (8 studies), with strength preferentially reduced in the lower limbs. Eight studies measured structural or metabolic characteristics and found evidence of reduced muscle size and oxidative stress. Findings of muscle injury and muscle inflammation (e.g. serum markers, electromyography and muscle biopsies) were reported primarily in individuals with idiopathic inflammatory myopathies and connective tissue diseases. Conclusions:Reduced volitional muscle strength was the most common finding of peripheral muscle dysfunction in ILD. Further quantification of peripheral muscle dysfunction and identification of structural and metabolic characteristics are needed to target specific interventions and optimize muscle function.

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Quadriceps strength and endurance in fibrotic idiopathic interstitial pneumonia

Abstract: Quadriceps strength and endurance are reduced in patients with fibrotic IIP compared with healthy controls, but are less tightly correlated with exercise performance.

Cited by 47 publications

References 37 publications

Exertional dyspnoea in interstitial lung diseases: the clinical utility of cardiopulmonary exercise testing

Exertional dyspnoea in interstitial lung diseases: the clinical utility of cardiopulmonary exercise testing

Current best practice in rehabilitation in interstitial lung disease

Peripheral Muscle Dysfunction in Interstitial Lung Disease: A Scoping Study

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