Qualitative analysis of lysergic acid diethylamide by means of the 10-hydroxy derivative

Mechanism of electrochemical oxidation of trimethoprim at pyrolytic graphite electrode

“…Brooks et aZ. [14] determined trimethoprim in a biological specimen based on its polarographic reduction. Bishop and Hussein [ 151 demonstrated that trimethoprim can undergo voltammetric oxidation in CH,CN in one well-defined peak at a rotating disk gold electrode.…”

N‐Oxidative Transformations ofCNGroups as Means of Toxification and Detoxification

“…Indeed, the antibacterial agent 2,4-diamino-5-(3,4,5-trimethoxybenzyl) O pyrimidine (trimethoprim) affords small amounts of its 1-N-oxide (42) and 3-N-oxide as urinary metabolites in rats, dogs and humans 105 . A species variation in the relative proportions of the isomeric N-oxides of trimethoprim formed has been reported: whereas man excretes about equal amounts of each isomer, rats and dogs excrete predominantly the 1-N-oxide and 3-N-oxide, respectively 105 . N-oxygenation in vitro of trimethoprim has also been documented using washed hepatic microsomal preparations from rats, hamsters, mice and guinea-pigs 16 .…”

Adsorptive stripping voltammetry of trimethoprim: Mechanistic studies and application to the fast determination in pharmaceutical suspensions

“…sulfamethoxazole (SMX), for the treatment of a number of bacterial infections [1][2][3][4]. Binary mixtures of TMP and SMX are current in commercial pharmaceutical preparations, like Bactrim (ratio 1:5), but TMP can be also supplied as a single agent.…”

“…Binary mixtures of TMP and SMX are current in commercial pharmaceutical preparations, like Bactrim (ratio 1:5), but TMP can be also supplied as a single agent. Analytical methods for the determination of TMP range from liquid chromatography [1,5,6] spectrophotometry [7][8][9], potentiometry [10], capillary zone electrophoresis [4] and capillary electrophoresis with amperometric detection at carbon electrodes [11,12], NMR [13] and electroanalysis [3,[14][15][16][17]. In the earlier electrochemical methods [3,14] the determination of TMP was achieved by polarographic reduction in acidic solutions.…”

“…Also, the proposed methods required sample pre-treatments, e.g. solvent extraction of the TMP, whenever the determination of TMP proceeded from pharmaceutical suspensions [14] or from other complex media like blood and urine [3]. Kotoucek et al [15] evaluated the mechanism of the polarographic reduction of TMP.…”