2023
DOI: 10.22159/ijap.2023v15i6.48850
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QUALITY BY DESIGN APPROACH FOR DEVELOPMENT AND OPTIMIZATION OF CHITOSAN-BASED FLOATING MICROSPHERES FOR TOPOTECAN HCl

PRAHLAD PRAGALLAPATI,
REVATHI NAGA LAKSHMI PONNURI,
VENKATA RAMANA MURTHY KOLLAPALLI

Abstract: Objective: To develop floating microspheres for the topotecan in order to prevent its onversion into inactive carboxylate form in intestinal pH conditions so as to improve its bioavailability. Methods: Chitosan-based porous floating microspheres containing sodium bicarbonate by coacervation technique were developed. Quality by design approach using Box-Behnken Design was adopted to assess the influences of selected formulation variables and their importance on the quality of the finished product. Results: The … Show more

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