Quality Control and Quality Assurance

Fan, Gaowei; Wang, Qingtao

doi:10.1007/978-981-16-1037-0_8

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…where E is the measured potential (mV), E o is the standard potential (mV) indicating initial potential for a sensor in targeted ion solution, NS is the Nernst slope (mV/dec) indicating sensor sensitivity, and 𝐶 0 is the concentration (mg/L) of the target ion. For the mass fabrication of MSP-ISM sensors, efficient QC/QA protocols should be developed to minimize the discrepancy of the E readings, assure the consistent values of E o and NS, and ultimately minimize the needs for (re)calibration 13,14 . However, traditional PVC (Polyvinyl chloride)-based material-wise design cannot simultaneously solve the problems of water layer formation inside the sensor polymer matrix and biofouling on the sensor surface (Fig.…”

Section: Introductionmentioning

confidence: 99%

Mass Fabrication and Smart Deployment of “Calibration-free" Miniature Solid-State Potentiometric Sensors towards Digital Water Infrastructure

Fan

Dai²,

et al. 2023

Preprint

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Achieving digital water infrastructures requires efficient in situ collection and swift interpretation of vast amounts of data under spatial and temporal variations. Existing water sensors suffer from inconsistent quality, incur frequent (re)calibration before and after deployment, and impede reliable data interpretation across water infrastructures. In this study, a novel quality control/quality assurance (QC/QA) regime was developed for mass fabrication of miniature solid-state potentiometric ion-selective membrane (MSP-ISM) sensors through material-wise and device-wise advancements. Our goal was to minimize the discrepancy of sensor readings, assure the consistence of sensor Nernst slope (NS) and standard potential (Eo), and ultimately alleviate the needs of (re)calibration towards calibration-free (CF). Specifically, the material-wise advancement was performed by modifying the key components (e.g., ion selective membrane and solid contact) of the polymer matrix to enhance the NS consistence among multiple pieces of NH4+ MSP-ISM sensors and reduce the standard deviation (SD) from 2.38 mV/dec to 0.27 mV/dec. The devise-wise advancement was conducted by fabricate polymer membranes using electrospray to and fabricating the substratum electrode using aerosol jet printing, through which the variation of the E0 values was diminished from 7.58 mV to 1.39 mV and the uniformity and homogeneity of each layer of sensors were improved. Furthermore, the recalibration-free capability of CF-MSP-ISM sensors was examined in real wastewater over 14 days consecutively, exhibiting excellent accuracy with a discrepancy of less than 2 mg/L against the lab-based validation results. Finally, smart deployment of multiple pieces of CF-MSP-ISM sensors along the length of an anoxic/oxic (A/O) system and precision feedback control were simulated a plug-flow aerobic flexible control (PFAFC) model. The simulation results demonstrate that energy consumption saving and greenhouse gas (GHG, with N2O as the example) emission reduction can achieve 38.4% and 68.7%, respectively, compared with the one using traditional “single-point” monitoring. This high-resolution sensor profiling-based precise control strategy has a great potential to renovate the existing treatment facilities highly relying on excess energy consumption to meet the effluent requirement and explore an energy-saving and resilient operation with mitigated GHG emission.

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Section: Introductionmentioning

confidence: 99%

Mass Fabrication and Smart Deployment of “Calibration-free" Miniature Solid-State Potentiometric Sensors towards Digital Water Infrastructure

Fan

Dai²,

et al. 2023

Preprint

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Assessing the comparability of cycle threshold values derived from five external quality assessment rounds for omicron nucleic acid testing

Fan

Jin²,

Wang

et al. 2023

Virol J

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Background A variety of open-system real-time reverse transcriptase polymerase chain reaction (RT-PCR) assays for several acute respiratory syndrome coronavirus 2 are currently in use. This study aimed to ensure the quality of omicron nucleic acid testing and to assess the comparability of cycle threshold (Ct) values derived from RT-PCR. Methods Five external quality assessment (EQA) rounds using the omicron virus-like particles were organized between February 2022 and June 2022. Results A total of 1401 qualitative EQA reports have been collected. The overall positive percentage agreement was 99.72%, the negative percentage agreement was 99.75%, and the percent agreement was 99.73%. This study observed a significant variance in Ct values derived from different test systems. There was a wide heterogeneity in PCR efficiency among different RT-PCR kits and inter-laboratories. Conclusion There was strong concordance among laboratories performing qualitative omicron nucleic acid testing. Ct values from qualitative RT-PCR tests should not be used for clinical or epidemiological decision-making to avoid the potential for misinterpretation of the results.

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Quality Control and Quality Assurance

Cited by 2 publications

References 44 publications

Mass Fabrication and Smart Deployment of “Calibration-free" Miniature Solid-State Potentiometric Sensors towards Digital Water Infrastructure

Mass Fabrication and Smart Deployment of “Calibration-free" Miniature Solid-State Potentiometric Sensors towards Digital Water Infrastructure

Assessing the comparability of cycle threshold values derived from five external quality assessment rounds for omicron nucleic acid testing

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