Quality control system for blood irradiation using a teletherapy unit

Abstract

The methodology developed in the present work provides appropriate storage conditions during irradiation of both red blood cells and platelet blood components using a teletherapy unit.

Quality control of blood irradiation: determination T cells radiosensitivity to cobalt‐60 gamma rays

“…23°C) during the irradiation process. A thermal device that provides appropriate storage conditions during the irradiation of blood com‐ponents with a teletherapy unit has been recently proposed 17 . Because of the dimensions of this device (20 cm in diameter and 20 cm in height), however, the dose distribution in the volume is more heterogeneous, and therefore we decided to build a more appropriate thermal device to store the blood bags during the process of irradiation used in this experiments.…”

Quality control of blood irradiation with a teletherapy unit: damage to stored red blood cells after cobalt‐60 gamma irradiation

“…These irradiators incorporate one to four gamma‐ray sources, usually 137 Cs. In the absence of a blood irradiator, however, other alternatives such as X‐rays produced by a linear accelerator or gamma rays derived from the 60 Co source of a cobalt teletherapy machine can be used for this purpose 11‐15 . Ultraviolet light (ultraviolet B) also inactivates T lymphocytes.…”

“…To guarantee temperatures below 6°C, the RBC units were stored in the thermal device of an automated mechanical system used to store blood bags during irradiation with a teletherapy unit 15 . To minimize the heterogeneity of the dose in the irradiated volume, the thermal device was rotated at 2 r.p.m.…”

Reduction of T-lymphocytes in Blood Samples Using X-ray of Two Different Energies

“…The most commonly reported setting for TA-GVHD is immunocompetent recipients of blood from biologically related (directed) or HLA identical donors. [12,14] The main stay of preventing TA-GVHD is the ionization radiation therapy of blood products. Leukocyte depletion using current technology is inadequate for this purpose in order to kill all T-cells in the blood of the donor which will attack host tissue [15].…”

“…[17] Thus, these lymphocytes are unable to proliferate in the host and therefore cannot mediate TA-GvHD proliferate in the host and therefore cannot mediate TA-GvHD. [14] …”