Quality evaluation for the surveillance system of human prion diseases in China based on the data from 2010 to 2016

Abstract

ABSTRACT. The surveillance of CJD or human prion diseases (PrDs) has been conducted for 10 y in China. To evaluate the quality of China CJD surveillance system, the collections of the clinical and epidemiological information, the sampling, the clinical examinations and laboratory tests and follow-up survey were separately analyzed based on the data from 2010 to 2015. The obtaining rates of clinicalinformation table, epidemiological-information table, sample inspection sheet and medical record of the referring patients from reporting units to the center of CJD surveillance maintained or reached at very high levels, being close to 100% in the past 3 y. 93.82%, 85.23%, 96.21% and 94.70% of the reported cases had the data of MRI, EEG, CSF 14-3-3 and PRNP sequencing, respectively. Follow-up surveys were conducted in about 50% cases in 2010 and 2011, 93.39% cases in 2012 and 100% cases in the last 3 y. High obtaining rates of the clinical and epidemiological data, high conducting rates of the relevant clinical examinations and laboratory tests, high performing rates of follow-up survey for every referring case reflect a good implemental capacity in China CJD surveillance system, which supplies solid basis for recognition and diagnosis of human prion diseases and guarantees good quality of China CJD surveillance system.

Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

“…However, in the following 13 years (2003-2016), a total of 26 infectious disease outbreaks/events, which was more than doubled, was reported. These 26 events involved humans with the following viral or bacterial infections: severe SARS [28], avian influenza virus H5N1 (2005)(2006), Neisseria mengititds serotype C sequence type complex T4821 (2003)(2004)(2005) [29], S. suis ST7 (2005) [30], avian influenza H5N1 [31], HGA (2006) [32], influenza H1N1 (2009) [33], New Bunyavirus (2009) [34][35][36], avian influenza H7N9 (2013) [37], dengue fever (2013) [38], West Nile virus (2014) [39], Zika virus (2015) [40], yellow fever (2016) [41], Rift Valley fever (2016) [42], Middle East respiratory syndrome (MERS) (2015) [43], poliomyelitis (Xinjiang) (2011) [6], Anaplasma capra (2014) [44], Shigella flexneri Xv (2003) [45], Tahyna virus (2006) [46], Babesia venatorum (2014) [47], Rickettsia sibirica BJ-90 (2012) [48], R. tarasevichiae (2012) [49], R. raoultii (2012) [50], Borrelia valaisiana (2010) [51], Anaplasma ovis-like (2014) [44], Wolbachia (2012) [52], adenovirus serotype 50 (2010) [53], and Creutzfeldt-Jakob disease [54].…”

Evaluation of the Disease Burden of Sporadic Creutzfeldt-Jacob Disease with the Surveillance Data from 2013 to 2017 in China

“…All information of the sCJD patients came from the National Center for CJD surveillance network, China CDC. The reporting and diagnostic procedures for various human prion diseases within National CJD surveillance network were described elsewhere (9). In this study, after excluding other diagnosed cases, we recruited all probable-diagnostic sCJD patients from 2013 to 2017, totally 753 cases.…”

“…China has started the national CJD surveillance since 2006. Up to 2018, thousands of sCJD cases and more than 150 cases of various genetic prion diseases have been diagnosed via National CJD surveillance network (8,9). Like the features of sCJD globally, the prevalence of Chinese sCJD patients does not reveal any seasonal-and geographic-association.…”

The associations of two SNPs in miRNA-146a and one SNP in ZBTB38-RASA2 with the disease susceptibility and the clinical features of the Chinese patients of sCJD and FFI

“…The diagnoses of sCJD and FFI were performed by China CJD Surveillance Center, according to the diagnostic criteria for human prion diseases issued by World Health Organization (WHO) [13,14] and by National Health and Family Planning Commission of the People's Republic of China (http://www.nhfpc.gov.cn/ewebeditor/uploadfile/ 2017/07/20170727150307976.pdf). The detailed processes for the diagnosis of human prion diseases in China CJD Surveillance System were described previously [14,15,16]. Briefly, the clinical data (including the results of EEG and MRI) and specimens of the suspected patients were collected by the clinician from hospitals, while their epidemiological data were collected by the staff of provincial CDCs.…”