Quality evaluation of guidelines for the diagnosis and treatment of radiation enteritis

Abstract

Objective To systematically evaluate the guidelines for the diagnosis and treatment of radioactive enteritis, compare their differences and reasons and provide some reference for updating them. Methods This study used guidelines related to radiation enteritis by searching a database. Four independent reviewers used the AGREE II evaluation tool to evaluate the quality of the included guidelines, collate their main recommendations, and analyze the highest evidence supporting the main recommendations. Results Six diagnostic and therapeutic guidelines for radiation enteritis were included in this study, one of which, the American Society for Gastrointestinal Endoscopy guidelines, had an overall score of over 60%, which is worthy of clinical recommendation. In the diagnosis and treatment of radioactive rectal injury, the recommendations for hemorrhagic endoscopic treatment are mature and mainly include (I) argon plasma coagulation; (II) formalin treatment; (III) bipolar electrocoagulation; (IV) heater probe; (V) radiofrequency ablation; and (VI) cryoablation. Conclusion The methodological quality of radioactive enteritis guidelines is unequal; even in the same guidelines, different domains have a large difference. For radioactive rectal damage diagnosis, a type of endoscopic treatment recommendation is more mature, but the overall diagnosis and treatment of radioactive enteritis still lacks high-quality research evidence.

FLASH radiotherapy using high-energy X-rays: validation of the FLASH effect triggered by a compact single high-energy X-ray source device

“…For CT26 cells, BAL b/c mice were inoculated in the hind flank with 5  10 5 cells. Tumors were irradiated when the tumor volume reached 30-100 mm 3 .…”

“…Cancer remains a leading cause of death worldwide, with an estimated 20 million new cases and approximately 9.7 million deaths reported in 2022 [1]. Radiotherapy, a commonly used treatment for cancer, is required by approximately 60-80% of affected patients throughout the course of the disease [2,3]. However, radiotherapy can damage the surrounding organs at risk (OARs), resulting in treatment interruption and impaired anti-tumor efficacy.…”