Quality of Life Assessment for Tonsillar Infections and Their Treatment

Hackenberg, Berit; Büttner, M; Schöndorf, Michelle; Strieth, Sebastian; Schramm, Wendelin; Matthias, Christoph; Gouveris, Haralampos

doi:10.3390/medicina58050589

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Indications for surgery comprise obstructive sleep-disordered breathing and recurrent throat infections, both of which can bring formidable impact on the quality of life and health status in people of all ages [3]. Some studies have shown that tonsillectomy can have a positive effect on a patient's life pattern including limitation in sleep, usual activities, vitality and discomfort, resulting in statistically improving their life quality [4][5][6]. However, complications such as postoperative nausea and vomiting, throat pain, dehydration, and bleeding are included after the surgical procedure [7,8].…”

Section: Introductionmentioning

confidence: 99%

Depression risk in chronic tonsillitis patients underwent tonsillectomy: a global federated health network analysis

Chang,

Lu,

Guo

et al. 2024

Int. J. Med. Sci.

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Background: Tonsillectomy is a common surgery in the US, with possible postoperative complications. While small studies indicate postoperative depressive symptoms may occur, large-scale evidence is lacking on the tonsillectomy-depression link. Methods: We conducted a retrospective cohort study using the TriNetX US collaborative network, offering de-identified electronic health data from 59 collaborative healthcare organizations (HCOs) in the United States. In this study, people being diagnosed of chronic tonsillitis between January 2005 and December 2017 were enrolled. Patients deceased, with previous record of cancers or psychiatric events before index date were excluded. 14,874 chronic tonsillitis patients undergoing tonsillectomy were propensity score matched 1:1 to controls for age, sex, and race. New-onset depression risks were evaluated over 5 years post-tonsillectomy and stratified by age and sex. Confounders were adjusted for including demographics, medications, comorbidities and socioeconomic statuses. Results: After matching, the difference of key baseline characteristics including age, sex, comedications status and obesity status was insignificant between tonsillectomy and non-tonsillectomy groups. Tonsillectomy had a 1.29 times higher 5-year depression risk versus matched controls (95% CI, 1.19-1.40), with elevated risks seen at 1 year (HR=1.51; 95% CI, 1.28-1.79) and 3 years (HR=1.30; 95% CI, 1.18-1.43). By stratifications, risks were increased for both males (HR=1.30; 95% CI, 1.08-1.57) and females (HR=1.30; 95% CI, 1.18-1.42), and significantly higher in ages 18-64 years (HR=1.37; 1.26-1.49), but no significance observed for those 65 years and older. After performing sensitivity analyses and applying washout periods of 6, 12, and 36 months, the outcome remained consistent with unadjusted results. Conclusion: This real-world analysis found tonsillectomy was associated with a 30% higher 5-year depression risk versus matched non-tonsillectomy patients with chronic tonsillitis. Further mechanistic research is needed to clarify the pathophysiologic association between depression and tonsillectomy. Depression is not commonly mentioned in the current post-tonsillectomy care realm; however, the outcome of our study emphasized the possibility of these suffering condition after operation. Attention to psychological impacts following tonsillectomy is warranted to support patient well-being, leading to better management of post-tonsillectomy individuals.

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Section: Introductionmentioning

confidence: 99%

Depression risk in chronic tonsillitis patients underwent tonsillectomy: a global federated health network analysis

Chang,

Lu,

Guo

et al. 2024

Int. J. Med. Sci.

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Antibiotics or Tonsillectomy for Adult Recurrent Tonsillitis: Analyzing the Lesser of Two Evils

Jacob,

Leshno,

Carmel‐Neidermann

et al. 2023

The Laryngoscope

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ObjectiveTo determine the best timing for surgical intervention for adults with recurrent tonsillitis (RT).MethodsA Markov model was constructed using variables and ranges based upon a literature review. A 1‐way sensitivity analysis was performed to evaluate the number of yearly bouts at which each algorithm (antibiotics or tonsillectomy) would be favored. A Monte‐Carlo probabilistic sensitivity analysis was calculated for gains and cost. Model outcomes were measured with quality‐adjusted life‐years (QALYs) and incremental cost‐effectiveness ratios (ICER) for tonsillectomy versus repeat antibiotic treatment.ResultsPatients expected to sustain a single annual tonsillitis event will have a negative QALY of 0.02 if treated with surgery and those with 2 annual events will have a QALY gain from undergoing tonsillectomy of 0.01, 3 events = 0.03, 4 events = 0.05, 5 events = 0.07, 6 events = 0.09, 7 events = 0.1, and 8 events = 0.11. These gains became meaningful only after 2 years of recurrent bouts. The average cost of tonsillectomy was 3,238 USD, and the overall average cost of RT was 7,069 USD (an incremental cost of 3,831 USD). The ICER of tonsillectomy over antibiotic treatment for 1 QALY gain was 44,741 USD.ConclusionAdult patients who sustain more than 3 annual bouts of tonsillitis over a period of at least 2 years will gain QALY after tonsillectomy. These gains increase proportionally to the number of yearly events and perennial episodes. The incremental costs of tonsillectomy fail to meet the NICE guidelines but are within other acceptable reference ranges.Level of EvidenceN/A Laryngoscope, 2023

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Knowledge and Awareness among Parents in the Aseer Region, Kingdom of Saudi Arabia, Regarding Complications of Recurrent Adenotonsillitis in Children and Its Surgical Treatment

Musleh,

Alshamrani,

Asiri

et al. 2023

King Khalid University Journal of Health Sciences

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Objective: The study emphasizes the importance of parental awareness regarding complications and surgical procedures associated with pediatric adenotonsillar hypertrophy. Methodology: A descriptive cross-sectional survey was used targeting parents of children aged 1–14 years in the Aseer region of Saudi Arabia. The sample size was 301 individuals. It includes parents of children between the ages of 1 and 14 years who are living in the Aseer region. Exclusion criteria involve anyone who does not live in the Aseer region, <18 years, and nonparents of children between the ages of 1 and 14 years. Results: The data presented are based on 301 people who volunteered to participate in the survey; a considerable majority of participants, 71.4%, correctly identified that recurrent adenotonsillitis could induce tonsil and adenoidal enlargement. However, 28.6% of respondents answered this question incorrectly. Conclusions: Our findings emphasize the necessity of parental education on the risks and surgical procedures related to adenotonsillar hypertrophy in pediatric patients. While some areas of knowledge were well recognized, there is an obvious need for additional education.

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Quality of Life Assessment for Tonsillar Infections and Their Treatment

Cited by 3 publications

References 27 publications

Depression risk in chronic tonsillitis patients underwent tonsillectomy: a global federated health network analysis

Depression risk in chronic tonsillitis patients underwent tonsillectomy: a global federated health network analysis

Antibiotics or Tonsillectomy for Adult Recurrent Tonsillitis: Analyzing the Lesser of Two Evils

Knowledge and Awareness among Parents in the Aseer Region, Kingdom of Saudi Arabia, Regarding Complications of Recurrent Adenotonsillitis in Children and Its Surgical Treatment

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