Quality of life in elderly men with aging symptoms and lower urinary tract symptoms (LUTS)

Perchon, Lygia; Pintarelli, Vitor; Bezerra, Edson; Thiel, Marcelo; Dambros, Míriam

doi:10.1002/nau.21008

Cited by 18 publications

(20 citation statements)

References 13 publications

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“…LUTS, particularly storage symptoms, have a negative impact on patients’ HRQoL . The present analyses of data from the NEPTUNE study indicate that the FDC of solifenacin 6 mg plus TOCAS significantly improved several HRQoL parameters, vs placebo and vs TOCAS monotherapy, in men with LUTS/BPH who had moderate‐to‐severe storage symptoms and voiding symptoms.…”

Section: Discussionmentioning

confidence: 65%

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Responder and health‐related quality of life analyses in men with lower urinary tract symptoms treated with a fixed‐dose combination of solifenacin and tamsulosin oral‐controlled absorption system: results from the NEPTUNE study

et al. 2015

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Responder and health-related quality of life analyses in men with lower urinary tract symptoms treated with a fixed-dose combination of solifenacin and tamsulosin oral-controlled absorption system: results from the NEPTUNE study ObjectiveTo evaluate the effect of a fixed-dose combination (FDC) of solifenacin and an oral-controlled absorption system (OCAS TM ) formulation of tamsulosin (TOCAS) on healthrelated quality of life (HRQoL) in men with lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH). Patients and methodsMen with moderate-to-severe storage symptoms and voiding symptoms were treated for 12 weeks with a FDC of solifenacin 6 or 9 mg plus TOCAS (0.4 mg), TOCAS monotherapy (0.4 mg) or placebo in a randomised, doubleblind study (NEPTUNE). The co-primary endpoints were Total Urgency Frequency Score (TUFS) and total International Prostate Symptom Score (IPSS). HRQoL was assessed by several secondary endpoints: IPSS QoL index, overactive bladder questionnaire (OAB-q), and Patient Global Impression (PGI) scale. The correlation between symptom improvement (TUFS) and HRQoL was assessed by Spearman rank correlation coefficients. Single and double responder analyses, using subjective and objective measures, were also performed. ResultsIn the responder analyses, men treated with a FDC of solifenacin 6 mg plus TOCAS consistently had significantly improved outcomes compared with placebo (8/8 responder analyses performed) and TOCAS (6/8 responder analyses performed). There was a significant correlation (P < 0.001) between the reduction in TUFS and the improvement in HRQoL defined by IPSS QoL score, OAB-q symptom bother score, PGI overall bladder symptoms and PGI general health. ConclusionsIn men with LUTS/BPH who have moderate-to-severe storage symptoms and voiding symptoms, the reduction in symptoms with a once-daily FDC of solifenacin and TOCAS was associated with consistent patient-relevant improvements in HRQoL compared with placebo and TOCAS monotherapy.Keywords benign prostatic hyperplasia, health-related quality of life, lower urinary tract symptoms, solifenacin, tamsulosin

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Section: Discussionmentioning

confidence: 65%

“…Other studies have shown that LUTS can negatively impact patients’ health‐related quality of life (HRQoL) . A cross‐sectional survey of 1 627 men aged 40–79 years found 51% of men with BPH reported interference with at least one daily living activity due to urinary dysfunction, compared with 28% of men without BPH .…”

Section: Introductionmentioning

confidence: 99%

Responder and health‐related quality of life analyses in men with lower urinary tract symptoms treated with a fixed‐dose combination of solifenacin and tamsulosin oral‐controlled absorption system: results from the NEPTUNE study

et al. 2015

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“…Aging has emerged as a major global public health issue that is associated with different types of morbidity, including cancer, cardiovascular diseases, and dementia. Advancing age is also considered a high risk factor for genitourinary tract diseases, being the lower urinary tract symptoms (LUTS) secondary to benign prostate hyperplasia (BPH) the most prevalent age‐related pathological condition in men . BPH is characterized by an increase in both physical size (static component) and prostate smooth muscle tone (dynamic component).…”

Section: Introductionmentioning

confidence: 99%

“…Advancing age is also considered a high risk factor for genitourinary tract diseases, being the lower urinary tract symptoms (LUTS) secondary to benign prostate hyperplasia (BPH) the most prevalent age-related pathological condition in men. 1 BPH is characterized by an increase in both physical size (static component) and prostate smooth muscle tone (dynamic component). The BPH pathogenesis is multifactorial and may include age-related changes in the nervous system and neuroregulatory factors, such as nitric oxide (NO) and RhoA/Rho-kinase.…”

Section: Introductionmentioning

confidence: 99%

Implication of Rho‐kinase and soluble guanylyl cyclase enzymes in prostate smooth muscle dysfunction in middle‐aged rats

Calmasini

Silva

Alexandre

et al. 2016

Neurourology and Urodynamics

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“…Regarding the aging process, quality of life is determined by the ability to maintain autonomy, decision-making, independence and ability to perform daily tasks (Freitas, Queiroz & Sousa, 2010), its decline may contribute to the risk of chronic degenerative diseases in different populations, mostly in men over the age of 40 years (Martits & Costa, 2004). Thus, it is important to maintain adequate levels of quality of life in this population (Perchon, Pintarelli, Bezerra, Thiel & Dambros, 2011).…”

Section: Introductionmentioning

confidence: 99%

Aging male symptoms: the relationship between physical activity and quality of life

Souza

Guimarães

2016

Motriz: rev. educ. fis.

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To examine the relationship between physical activity (PA) and the aging male symptoms of middle-aged men in the quality of life (QOL). Methodology: Cross-sectional study with a probabilistic samples of 416 men (40-59 years old), all residents in two cities in southern of Brazil. A questionnaire was used. The studied population was divided into two groups: with and without symptoms. The analyses were carried out in a descriptive and inferential approaches. Results: Aging male symptoms were related to QOL. Men who perceive their overall QOL as good presented a13% lower probability of (95%CI = 0.77-0.98) being insufficiently active. For those with symptoms, QOL scores were higher in social and environmental domain in PA between 30-60 min/day, and the physical domain for more than 60min/day. Conclusion: Our findings show the importance of PA to achieve significant benefits in QOL and health of men in middle age with aging male symptoms.

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Quality of life in elderly men with aging symptoms and lower urinary tract symptoms (LUTS)

Cited by 18 publications

References 13 publications

Responder and health‐related quality of life analyses in men with lower urinary tract symptoms treated with a fixed‐dose combination of solifenacin and tamsulosin oral‐controlled absorption system: results from the NEPTUNE study

Responder and health‐related quality of life analyses in men with lower urinary tract symptoms treated with a fixed‐dose combination of solifenacin and tamsulosin oral‐controlled absorption system: results from the NEPTUNE study

Implication of Rho‐kinase and soluble guanylyl cyclase enzymes in prostate smooth muscle dysfunction in middle‐aged rats

Aging male symptoms: the relationship between physical activity and quality of life

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