Quality of Life in Gestational Trophoblastic Neoplasia Patients after Treatment in Thailand

Leenharattanarak, Pattaramon; Lertkhachonsuk, Ruangsak

doi:10.7314/apjcp.2014.15.24.10871

Cited by 9 publications

(6 citation statements)

References 15 publications

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“…Post-treatment quality of life has been studied in different oncologic scenarios(24, 25) but never for the treatment of ocular surface squamous neoplasia. In this study, we used a cohort of patients with medical and surgical treatment, of which both groups had similar clinical outcomes, proving medical and surgical therapy are good first-line options in treating OSSN(3, 8).…”

Section: Discussionmentioning

confidence: 99%

Surgical versus medical treatment for ocular surface squamous neoplasia: A quality of life comparison

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Surgical versus medical treatment for ocular surface squamous neoplasia: A quality of life comparison

et al. 2019

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“…Hydatidiform mole is a benign trophoblastic tumor 27 and accounts for the majority of GTD; about 80% of GTDs are hydatidiform moles 13 . Hydatidiform mole is associated with abnormal gametogenesis and fertilization.…”

Section: Gestational Trophoblastic Diseasementioning

confidence: 99%

Understanding and management of gestational trophoblastic disease

et al. 2019

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Gestational trophoblastic disease or neoplasia covers a spectrum of benign and malignant conditions arising from pregnancies with highly abnormal development of trophoblastic tissue. In this brief review, we discuss the different features of these different conditions and their origins and risk factors and introduce some of the more novel and controversial treatment options currently being explored.

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“…Seven of the studies, 15,16,[23][24][25][26][27] that include GTN patients measure HRQoL use a validated generic HRQoL tool (FACT-G, EORTC QLQ-C30, WHOQOL-BREF, SWLS, QoL-CS, SF 36 and the SF 12). Of these, there is a mixture of patients already in remission and patients undergoing active treatment.…”

Section: General Hrqolmentioning

confidence: 99%

“…Of these, there is a mixture of patients already in remission and patients undergoing active treatment. Where the study only includes patients in remission, [24][25][26][27] the results show levels of HRQoL at or above population norms (Table IV). Within FACT-G scores there were no significant differences based on population characteristics; however patients who desired further fertility showed significantly lower FACT-G score in the emotional well-being domain (p=0.02).…”

Section: General Hrqolmentioning

confidence: 99%

“…Within FACT-G scores there were no significant differences based on population characteristics; however patients who desired further fertility showed significantly lower FACT-G score in the emotional well-being domain (p=0.02). 26 Studies including patients either in remission or during active treatment are undermined by a lack of information on disease status. 15,16,23 Two studies using the EORTC-QLQ-C30 and the SWLS demonstrate that chemotherapy significantly reduces overall HRQoL.…”

Section: General Hrqolmentioning

confidence: 99%

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Systematic review of health-related quality of life and patient-reported outcome measures in gestational trophoblastic disease: a parallel synthesis approach

Ireson

Jones

Winter

et al. 2018

The Lancet Oncology

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Gestational trophoblastic disease is a rare complication of pregnancy that can develop into cancer. Medical outcomes of gestational trophoblastic disease are well researched, but the effect of the disease on health-related quality of life (HRQOL) requires attention if care is to be improved. This systematic review was designed to establish the effect of gestational trophoblastic disease and its treatment on HRQOL and to identify the appropriateness of HRQOL measures. Quantitative studies found HRQOL in long-term survivors of gestational trophoblastic disease to be at or above population norms. The disease had a negative effect on HRQOL for patients who experienced physical, psychological, and social sequelae related to the condition. Clinically significant levels of anxiety, depression, sexual dysfunction, and fertility-related distress were found in these patients. The results should be treated with caution because the evidence base was limited to small heterogeneous samples, data were retrospective, and a range of measures was used. Within qualitative studies on HRQOL for survivors of gestational trophoblastic disease, new conditions emerged, including nerve damage, fatigue, amenorrhoea, and grief. These areas are not captured in existing patient-reported outcome measures, and the content might not be valid for this population. Further qualitative research might lead to the development of a specific patient-reported outcome measure for gestational trophoblastic disease, providing reliable, meaningful, and valid assessments, and allowing longitudinal data to be obtained.

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Quality of Life in Gestational Trophoblastic Neoplasia Patients after Treatment in Thailand

Cited by 9 publications

References 15 publications

Surgical versus medical treatment for ocular surface squamous neoplasia: A quality of life comparison

Surgical versus medical treatment for ocular surface squamous neoplasia: A quality of life comparison

Understanding and management of gestational trophoblastic disease

Systematic review of health-related quality of life and patient-reported outcome measures in gestational trophoblastic disease: a parallel synthesis approach

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