Quality of life in patients with smell loss due to upper respiratory tract infections

Toledano, A; Rodríguez, Gil; Martín, Armando González; Onrubia, Tomás; Galindo, Néstor

doi:10.1016/j.amjoto.2010.11.002

Cited by 16 publications

(16 citation statements)

References 16 publications

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“…CRS creates a tremendous economic burden, with direct healthcare costs of ~$6 billion annually in the USA [4–8]. Moreover, patients requiring sinus surgery for CRS report worse quality-of-life scores for physical pain and social functioning than patients suffering from chronic obstructive pulmonary disease, congestive heart failure, or angina [9–11]. …”

Section: Introductionmentioning

confidence: 99%

Bitter and sweet taste receptors in the respiratory epithelium in health and disease

Lee

Cohen

2014

J Mol Med

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Taste receptors on the tongue communicate information to the brain about the nutrient content or potential toxicity of ingested foods. However, recent research has now shown that taste receptors are also expressed far beyond the tongue, from the airway and gastrointestinal epithelia to the pancreas and brain. The functions of many of these so-called extraoral taste receptors remain unknown, but emerging basic science and clinical evidence suggests that bitter and sweet taste receptors in the airway are important in sensing bacteria and regulating innate immunity. This review focuses on the role of bitter and sweet taste receptors in human airway innate immunity and the potential clinical relevance to airway infections. The T2R38 bitter taste receptor in sinonasal cilia detects bitter bacterial quorum-sensing molecules and activates nitric oxide-dependent innate immune responses. Polymorphisms that underlie T2R38 functionality also appear to be involved in susceptibility to upper respiratory infection and chronic rhinosinusitis (CRS). Bitter and sweet receptors in specialized sinonasal solitary chemosensory cells control antimicrobial peptide secretion, which may have important implications for airway infections in CRS patients as well as patients with diabetes mellitus. Future research on taste receptors in the airway has tremendous potential to identify immune mechanisms involved in host-pathogen interactions and thus reveal novel therapeutic targets.

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Section: Introductionmentioning

confidence: 99%

Bitter and sweet taste receptors in the respiratory epithelium in health and disease

Lee

Cohen

2014

J Mol Med

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“…Given the role of olfaction in our daily lives, olfactory loss may significantly affects quality of life (QoL) and mood . Furthermore, patients with anosmia or decreased smell often report experiencing a feeling of personal isolation, show less interest in eating, and become emotionally stunted …”

Section: Introductionmentioning

confidence: 99%

Does post‐infectious olfactory loss affect mood more severely than chronic sinusitis with olfactory loss?

2014

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“…Loss of smell has been shown to have a negative impact on mood, social interactions, and overall quality of life (QOL). 5,6 Olfactory loss may be caused by various respiratory viruses, including the influenza virus. Because of the highly contagious nature of seasonal influenza and its associated morbidity and mortality, seasonal vaccination programs have been instituted in this country and around the world.…”

mentioning

confidence: 99%

Association of Decreased Rate of Influenza Vaccination With Increased Subjective Olfactory Dysfunction

Flanagan

Wise

DelGaudio

et al. 2015

JAMA Otolaryngol Head Neck Surg

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Quality of life in patients with smell loss due to upper respiratory tract infections

Cited by 16 publications

References 16 publications

Bitter and sweet taste receptors in the respiratory epithelium in health and disease

Bitter and sweet taste receptors in the respiratory epithelium in health and disease

Does post‐infectious olfactory loss affect mood more severely than chronic sinusitis with olfactory loss?

Association of Decreased Rate of Influenza Vaccination With Increased Subjective Olfactory Dysfunction

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