Quality of life in patients with cervical cancer after open versus minimally invasive radical hysterectomy (LACC): a secondary outcome of a multicentre, randomised, open-label, phase 3, non-inferiority trial

Frumovitz, Michael; Obermair, Andreas; Coleman, Robert L.; Pareja, René; López, Aldo; Ribero, Reitan; Isla, David; Rendón, Gabriel; Bernardini, Marcus Q.; Buda, Alessandro; Moretti-Marquez, Renato; Zevallos, Albert; Vieira, Marcelo Andrade da Costa; Zhu, Tao; Land, Russell; Nicklin, James L.; Asher, Rebecca; Robledo, Kristy; Gebski, Val; Ramírez, Pedro T.

doi:10.1016/s1470-2045(20)30081-4

Cited by 71 publications

(61 citation statements)

References 33 publications

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“…1 In a landmark clinical trial of cervical cancer, the compliance rate of at least one QoL survey was 79%, showing the difficulty on this issue. 5 Notably, even during the pandemic, we found a potentially better patients' compliance with telemedicine compared to our previous experience.…”

Section: Telemedicine and Cancer Research During The Covid-19 Pandemicmentioning

confidence: 43%

Telemedicine and cancer research during the COVID‐19 pandemic

Gonçalves

Baiocchi

2020

Journal of Surgical Oncology

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Section: Telemedicine and Cancer Research During The Covid-19 Pandemicmentioning

confidence: 43%

Telemedicine and cancer research during the COVID‐19 pandemic

Gonçalves

Baiocchi

2020

Journal of Surgical Oncology

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“…The authors concluded that open radical hysterectomy should be recommended for patients with early-stage cervical cancer. [ 38 ]…”

Section: T He P Ost L Aparoscopic a Pproach To C Ermentioning

confidence: 99%

Cervical Cancer Surgery

Yang

Huang

Yang

et al. 2021

Gynecology and Minimally Invasive Therapy

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Cervical cancer surgery has a history of more than 100-years whereby it has transitioned from the open approach to minimally invasive surgery (MIS). From the era of clinical exploration and practice, minimally invasive gynecologic surgeons have never ceased to explore new frontiers in the field of gynecologic surgery. MIS has fewer postoperative complications, including reduction of treatment-related morbidity and length of hospital stay than laparotomy; this forms the mainstay of treatment for early-stage cervical cancer. However, in November 2018, the New England Journal of Medicine had published two clinical studies on cervical cancer surgery (Laparoscopic Approach to Cervical Cancer [LACC]). Following these publications, laparoscopic surgery for early-stage cervical cancer has come under intense scrutiny and negative perceptions. Many studies began to explore the concept of standardized surgery for early-stage cervical cancer. In this article, we performed a review of the history of cervical cancer surgery, outlined the standardization of cervical cancer surgery, and analyzed the current state of affairs revolving around cervical cancer surgery in the post-LACC era.

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“…A battery of analyses of the LACC trial has now added additional information that minimally invasive radical hysterectomy for early cervical cancer is not associated with improved quality of life after surgery compared with open radical hysterectomy. [1][2][3] Taken together with the prior principal findings of the LACC trial including (1) increased risk of disease recurrence/death and (2) similar peri-operative morbidity in minimally invasive versus open radical hysterectomy, 2 3 the study team recommended that gynecologic oncologists perform open radical hysterectomy for women with early cervical cancer. 1 Because comparable survival, reduced surgical adverse events, and improved quality of life were the expected premise for performance of minimally invasive over open surgery, failure to demonstrate these three outcome measures argues against the utilization of a minimally invasive approach for cervical cancer treatment.…”

Section: Gynecological Cancermentioning

confidence: 99%