Quality of life in simultaneous pancreas–kidney transplant recipients

Abstract

: Background: Simultaneous pancreas‐kidney transplantation (SPK Tx) allows dialysis and insulin therapy to be discontinued and improves the complications of diabetes mellitus type 1 (DM1). This study measure quality of life (QoL) in SPK transplant recipients and determine if there are differences in QoL between these patients and those with DM1 in renal replacement therapy (RRT). Methods: Short Form Health Survey 36‐Item (SF‐36) was administered to 69 SPK transplant recipients and 34 patients with DM1 under RRT. A descriptive analysis, multiple linear regression, ANOVA, and ordinal regression (PLUM) models were constructed. Results: QoL was higher in SPK transplant recipients than in patients receiving RRT. The best results were in the recently transplanted patients. Respect to Spanish population the men with SPK transplants scored higher on vitality and lower on general health, role limitations‐physical and role limitations‐emotional. Women with SPK transplants scored lower on general health. Among patients under RRT, men scored lower on the general health, physical functioning, vitality, and bodily pain while women scored lower on all dimensions. In both groups, greater age was associated with better mental health. Conclusion: Positive predictive factors of QoL are SPK Tx and age while negative predictive factors are female sex and RRT.

Simultaneous Pancreas Kidney Transplant versus Other Kidney Transplant Options in Patients with Type 2 Diabetes

“…Although the findings on multivariable analysis do not suggest a beneficial effect of the added pancreas transplant on kidney graft or patient survival per se, this should not dissuade consideration of SPK for the selected T2DM candidate who does not have a living donor available. Our findings do not consider the benefits of euglycemia on quality of life (10,11) or the possible effect on secondary complications of diabetes, as has been described in T1DM recipients (12). In addition, the effect of euglycemia on graft or patient survival may not be apparent until beyond 5 years (12).…”

Hverdagen etter nyre–pankreas-transplantasjon

“…Earlier studies examining the post-transplant lives of KPT patients have mainly used quantitative mapping of self-perceived quality of life (2,(5)(6)(7)10). Few studies have investigated patients' experiences in the transition from life with diabetes and renal failure to daily life after a KPT.…”

“…These themes were the transition from life with a chronic illness to life after the transplantation, social relationships and follow-up after the transplantation. We chose these themes based on findings from studies of quality of life following a KPT (2,(5)(6)(7)10), transplant recipients' experiences (8,9,12) and clinical experiences from transplant surgical wards.…”

“…Patients who have undergone a KPT often report an improvement in their quality of life (2,(5)(6)(7). Nevertheless, KPTs present new challenges in their daily lives.…”

Simultaneous pancreas-kidney transplantation: The role in the treatment of type 1 diabetes and end-stage renal disease

“…21 Smith and colleagues compared pre-and post-transplant quality of life and found significant improvement following SPK transplantation. 22 Snort-form-36 Mental Component Summary scores were significantly higher 2 years post-transplant compared to pre-transplant (51.8 vs. 46.8).…”