Quantificação de Corpos de Neurônios em Camundongos Submetidos ao Uso de Esteróides Anabolizantes

Damião, Bruno; Souza, Guilherme Gonzales de; Nogueira, Denismar Alve; Rossi, Wagner Costa; Fernandes, Geraldo José Medeiros; Esteves, Alessandra

doi:10.34024/rnc.2012.v20.8303

Cited by 12 publications

(25 citation statements)

References 12 publications

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“…In face of the results obtained in the brain cortex, it can mean the chronic treatment with the specified AAS doses of this work contributed to the reduction of neuron number in the limbic, motor and sensitive areas of the cortex, like the results of previous researches [13,37], were the anabolic steroids demonstrated association with neuronal loss in the same regions of the brain cortex.…”

Section: Discussionsupporting

confidence: 58%

“…These data combined suggest that AAS use during adolescence can lead to behavioral effects more pronounced and lasting than in adults [11,12]. Different researchers also indicate that AAS use increases the chances of neuron death in different brain regions in mice [13,14,15].…”

Section: Introductionmentioning

confidence: 86%

“…Encephalon fragments were processed following standardized histological procedure [13,15]. To estimate the neuron density, simple random sampling method was used [22,23,24,25].…”

Section: Methodsmentioning

confidence: 99%

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Chronic Use of Anabolic Steroids and the Effects on the Neuronal Density of the Cerebral Cortex and Hippocampus in Mice

Silva¹

2018

AJSS

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This study analyzed the effects of the chronic use of these drugs on the neuronal density of mice cerebral cortex and hippocampus. Materials and methods: 40 male Swiss mice were used, divided into 4 groups (n=10): GI-Control (0,02ml/Kg/week of saline solution), GII-treated with anabolic steroid Durateston® (83,3mg/Kg/week) GIII-treated with anabolic steroid Deca Durabolin® (16,6mg/Kg/week) e GIV-treated with the two anabolic steroids, concomitantly. The mice were treated for sixty days (60) and practiced swimming three times a week. The brain fragments were processed following the standardized sequence in conventional histological procedures and stained using cresyl violet. For the neuronal density analysis, the simple random count methodology was used. Results: Data revealed a significant reduction in the neuronal density of the groups treated with anabolic steroids, the limbic area had an estimated decrease of 16.44% in group III and 29.21% in group IV; the motor area the groups II, III, and IV presented a reduction of 17.63%, 15.35%, and 12.23%, and in the sensory area 15.22%, 16.41% and 21.59%, respectively; the groups II, III, and IV of the Ca1 area of the hippocampus showed a neuronal loss of 23.5%, 27.8%, and 36.36%, while groups II, III and IV of the Ca2 area there was a reduction of 10.37%, 11.83%, and 16.34%. In conclusion, the chronic use of AAS can be harmful to the nervous system since the neuronal reduction can bring structural and functional damages with possible consequences the whole organism.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 86%

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Chronic Use of Anabolic Steroids and the Effects on the Neuronal Density of the Cerebral Cortex and Hippocampus in Mice

Silva¹

2018

AJSS

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“…Outras pesquisas com modelos animais avaliaram o impacto dos anabolizantes sob o número médio dos corpos dos neurônios do córtex cerebral, administrando esteroides anabolizantes nos animais e, posteriormente, estimulando-os fisicamente através da natação. Desta forma, os pesquisadores analisaram a quantificação dos neurônios, constatando, assim, a diminuição de 30% da densidade média dos corpos dos neurônios nos animais submetidos ao tratamento com esteroides anabolizantes androgênicos (Damião et al, 2012). Com isto, concluíram que o consumo indiscriminado de esteroides anabolizantes pode levar a degenerações severas no sistema nervoso central, produzindo perda de atividades cerebrais e cognitivas (Damião et al, 2012; Tabela 1).…”

Section: Dados De Experimentos Em Modelos Animaisunclassified

Psicobiologia do anabolismo: um estudo bibliográfico das alterações no sistema de recompensa cerebral decorrentes do consumo indiscriminado de esteroides anabolizantes

Medeiros¹,

Alves²,

Nogueira³

2018

Psique

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This research investigated whether the consumption of androgenic anabolic steroids can cause alteration in the brain's reward system. It is a qualitative research in which the bibliographical method of the state of the question was used; an analysis was made about the current situation of the research object in the international scientific field. The CAPES journal platform was consulted, and initially, a search was made to find research published in the Portuguese language using the descriptors: "Brain reward system", "Anabolic-androgenic steroids" and the combination of both. Then, after realizing that the Brazilian scientific literature about this subject was scarce, a search was made to find articles published in other languages. A survey of articles, books, and scholarly works addressing pertinent questions was carried out and they helped to answer the objectives of this study. Thus, the definition of what androgenic anabolic steroids are was advanced. The close relationship between the use of psychoactive substances and the brain's mechanism of reward and pleasure was analyzed. A global analysis was made, which indicated that the recurrent consumption of anabolic steroids can alter the functioning of the brain' s reward system, which can also result in chemical addiction and other psychobiological damages that affect the quality of life of users.

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“…Neste número da Revista Neurociências é publicado o estudo sobre a quantificação de corpos de neurônios em camundongos submetidos ao uso de esteróides anabolizantes 1 . Os esteróides anabolizantes são drogas sinteticamente derivadas da testosterona 2 .…”

Section: Rivelilson Mendes De Freitasunclassified