Quantification and Discrimination of Abnormal Sulcal Patterns in Polymicrogyria

Im, Kiho; Pienaar, Rudolph; Paldino, Michael J.; Gaab, Nadine; Galaburda, Albert M.; Grant, P. Ellen

doi:10.1093/cercor/bhs292

Cited by 37 publications

(36 citation statements)

References 51 publications

(72 reference statements)

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“…65 Quantitative measurements of abnormal sulcal patterns have made it possible to correlate morphologic abnormalities with language impairment. 66 Future 7T functional MR imaging studies are needed to clarify the correlation between abnormal sulcal patterns and functional impairment.…”

Section: Discussionmentioning

confidence: 99%

Ultra-High-Field MR Imaging in Polymicrogyria and Epilepsy

Ciantis

Barkovich

Cosottini

et al. 2014

AJNR Am J Neuroradiol

101

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BACKGROUND AND PURPOSE Polymicrogyria is a malformation of cortical development that is often identified in children with epilepsy or delayed development. We investigated in vivo the potential of 7T imaging in characterizing polymicrogyria to determine whether additional features could be identified. MATERIALS AND METHODS Ten adult patients with polymicrogyria previously diagnosed by using 3T MR imaging underwent additional imaging at 7T. We assessed polymicrogyria according to topographic pattern, extent, symmetry, and morphology. Additional imaging sequences at 7T included 3D T2* susceptibility-weighted angiography and 2D tissue border enhancement FSE inversion recovery. Minimum intensity projections were used to assess the potential of the susceptibility-weighted angiography sequence for depiction of cerebral veins. RESULTS At 7T, we observed perisylvian polymicrogyria that was bilateral in 6 patients, unilateral in 3, and diffuse in 1. Four of the 6 bilateral abnormalities had been considered unilateral at 3T. While 3T imaging revealed 2 morphologic categories (coarse, delicate), 7T susceptibility-weighted angiography images disclosed a uniform ribbonlike pattern. Susceptibility-weighted angiography revealed numerous dilated superficial veins in all polymicrogyric areas. Tissue border enhancement imaging depicted a hypointense line corresponding to the gray-white interface, providing a high definition of the borders and, thereby, improving detection of the polymicrogyric cortex. CONCLUSIONS 7T imaging reveals more anatomic details of polymicrogyria compared with 3T conventional sequences, with potential implications for diagnosis, genetic studies, and surgical treatment of associated epilepsy. Abnormalities of cortical veins may suggest a role for vascular dysgenesis in pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Ultra-High-Field MR Imaging in Polymicrogyria and Epilepsy

Ciantis

Barkovich

Cosottini

et al. 2014

AJNR Am J Neuroradiol

101

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“…Polymicrogyria may be unilateral or bilateral, frontal, frontoparietal, perisylvian, parieto-occipital or generalized (26,27). In localized form, the remaining cortical gray matter may be abnormal (28).…”

Section: Discussionmentioning

confidence: 99%

Assessment of the diagnostic reliability of brain CT and MRI in pediatric epilepsy patients

Alam-Eldeen

Hasan

2015

The Egyptian Journal of Radiology and Nuclear Medicine

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Objective: Analysis of the role of CT and MRI in evaluation of pediatric epilepsy and their diagnostic utility to detect various pathologic entities at one center. Patients and methods: From April 2012 to April 2014, 181 children with epilepsy were underwent standardized CT and or MRI in the Department of Diagnostic Radiology at Sohag University Hospitals. We retrospectively analyzed whether lesions were detected and whether were precisely characterized by CT and or MRI. Results: Of the 181 patients included in the study, abnormalities were detected in 132 patients (73%) while normal brain images were found in 49 patients (27%). Of the 74 patients had CT only, abnormalities were detected in 73% while 27% were normal. Of the 89 patients underwent MRI only, abnormalities were detected in 74% while 26% were normal. Of the 18 patients underwent CT and MRI, abnormalities were detected in 67% while 33% were normal. Conclusion: Seizure disorders are among the most frequent neurologic problems that occur in childhood. MRI is the technique of choice and is superior to CT in identifying underlying cause. However, CT can serve as a screening modality and MRI would be performed to define abnormalities found on CT or in negative CT studies.

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“…Sulcal basins are concave substructures decomposed from one large part of cortical folds 29 . Cortical mean curvature and depth on a surface model were measured using the FreeSurfer (surfer.nmr.mgh.harvard.edu), and sulcal basins were automatically identified using a watershed algorithm based on the curvature map 12, 13, 23, 29 (Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

“…We previously developed a comprehensive and quantitative analytical method for comparing primary sulcal patterns using not only the regional features of sulci folds themselves, but also the inter-sulcal geometric and topological relationships 23 . This method provided an effective means for detecting genetically-influenced abnormal sulcal patterns in pediatric patients with cerebral malformations 10, 12 and developmental dyslexia 13 .…”

Section: Introductionmentioning

confidence: 99%

Quantitative Folding Pattern Analysis of Early Primary Sulci in Human Fetuses with Brain Abnormalities

Guimarães

Kim

et al. 2017

AJNR Am J Neuroradiol

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Background and Purpose Aberrant gyral folding is a key feature in the diagnosis of many cerebral malformations. However, in fetal life it is particularly challenging to confidently diagnose aberrant folding due to the rapid spatiotemporal changes of gyral development. Currently, there is no resource to measure how an individual fetal brain compares to normal spatiotemporal variations. In this study we assess the potential for automatic analysis of early sulcal patterns to detect individual fetal brains with cerebral abnormalities. Materials and Methods Triplane MR images were aligned to create a motion-corrected volume for each individual fetal brain and cortical plate surfaces were extracted. Sulcal basins were automatically identified on the cortical plate surface and compared with a combined set generated from 9 normal fetal brain templates. Sulcal pattern similarities to the templates were quantified using multivariate geometric features and inter-sulcal relationships for 14 normal fetal brains and 5 fetal brains proven abnormal on postnatal MRI. Results were compared to gyrifixation index. Results Significantly reduced sulcal pattern similarities to normal templates were found in all abnormal individual fetuses compared to normal fetuses (mean similarity [normal, abnormal], left: 0.818, 0.752; P < .001, right: 0.810, 0.753; P < .01). Altered location and depth patterns of sulcal basins were the primary distinguishing features. Gyrification index was not significantly different between the normal and abnormal groups. Conclusion Automated analysis of interrelated patterning of early primary sulci could outperform traditional gyrification index and has the potential to quantitatively detect individual fetuses with emerging abnormal sulcal patterns.

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Quantification and Discrimination of Abnormal Sulcal Patterns in Polymicrogyria

Cited by 37 publications

References 51 publications

Ultra-High-Field MR Imaging in Polymicrogyria and Epilepsy

Ultra-High-Field MR Imaging in Polymicrogyria and Epilepsy

Assessment of the diagnostic reliability of brain CT and MRI in pediatric epilepsy patients

Quantitative Folding Pattern Analysis of Early Primary Sulci in Human Fetuses with Brain Abnormalities

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