Quantification and evaluation of thymoquinone loaded mucoadhesive nanoemulsion for treatment of cerebral ischemia

RETRACTED ARTICLE: Impact of ultrasonication techniques on the preparation of novel Amiloride-nanoemulsion used for intranasal delivery in the treatment of epilepsy

“…As per the reported method Ahmad et al [12], droplet size, polydispersity index (PDI) zeta potential, scanning electron microscopy and transmission electron microscopy (TEM) of the investigated samples were obtained (in triplicate) by calculating the average of thirteen measurements at an angle of 173 C.…”

“…In order to get an idea regarding the globule size and stability of the formulation, % transmittance (650 nm) for developed formulations was observed spectrophotometrically (Shimadzu, UV-1601, Kyoto, Japan). The blank used was distilled water and no dilution for any formulation was carried out in this process [12].…”

“…Abbes type refractometer (Bellinghan and Stanley Ltd., Tunbridge Wells, UK), was used to determine the RI of the samples in triplicate whereas the mean value and standard deviation (SD) for the data was calculated [12].…”

“…In addition the added advantages of nano-emulsion, i.e. being small particle size, incorporable in different ingredients and enhancement of nasal mucosa permeability, further enhance the drug action [11,12].…”

Quantification of rutin in rat’s brain by UHPLC/ESI-Q-TOF-MS/MS after intranasal administration of rutin loaded chitosan nanoparticles

“…5), for RT-CS-NPs. The particle size, is although within the range of optimum particle size for intranasal brain drug delivery as reported (Ahmad et al, 2013[3], 2016[2]), still other parameters were studied in order to optimize our formulation, i.e. TTP concentration, CS concentration, pH and stirring speed in order to obtain small particles, maximum loading with maximum encapsulation efficiency as well as PDI (0.206).…”