1993
DOI: 10.1289/ehp.93101s3219
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Quantification and molecular characterization of hprt mutants of human T-lymphocytes.

Abstract: Somatic mutations have been implicated as critical early events in carcinogenesis. Point mutations, deletions, and translocation events have been shown to activate oncogenes or inactivate suppressor oncogenes. In human population monitoring, quantitative analysis of mutation events that affect gene function is limited to those genes whose cellular phenotypes can be identified by selection procedures and to those tissues (like blood) that are accessible for analysis. In an effort to determine the frequency and … Show more

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Cited by 5 publications
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