Quantification of apparent axon density and orientation dispersion in the white matter of youth born with congenital heart disease

Easson, Kaitlyn; Rohlicek, Charles V.; Houde, Jean‐Christophe; Gilbert, Guillaume; Saint‐Martin, Christine; Fontes, Kimberly; Majnemer, Annette; Marelli, Ariane J.; Wintermark, Pia; Descoteaux, Maxime; Brossard‐Racine, Marie

doi:10.1016/j.neuroimage.2019.116255

Cited by 23 publications

(27 citation statements)

References 61 publications

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“…Previous studies have demonstrated that altered white matter microstructure in CHD is not restricted to the CST but is a rather global trait evident across the whole brain ( Brewster et al, 2015 , Ehrler et al, 2021 , Ehrler et al, 2020 , Rollins et al, 2014 , Watson et al, 2018 ), which can already be detected postnatally and is associated with decreased oxygen delivery ( Karmacharya et al, 2018 , Kelly et al, 2019 ). Of note is that two previously conducted studies in adolescents with CHD did not find any significant difference in FA of the CST compared to controls, while there was significantly lower FA in other major tracts ( Easson et al, 2020 , Watson et al, 2018 ). Different methodological approaches may partly explain these contradicting results ( Ressel et al, 2018 ).…”

Section: Discussionmentioning

confidence: 60%

Microstructural alterations of the corticospinal tract are associated with poor motor function in patients with severe congenital heart disease

Ehrler

Rhein

Schlosser

et al. 2021

NeuroImage: Clinical

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Highlights Congenital heart disease (CHD) patients are at risk for developmental impairments. CHD patients have a higher rate of motor impairments compared to controls. Fractional anisotropy of the corticospinal tract (FA CST) is lower in CHD patients. Lower FA CST is associated with poorer motor function in patients with complex CHD. Altered primary motor pathway development may lead to motor impairments in CHD.

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Section: Discussionmentioning

confidence: 60%

Microstructural alterations of the corticospinal tract are associated with poor motor function in patients with severe congenital heart disease

Ehrler

Rhein

Schlosser

et al. 2021

NeuroImage: Clinical

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“…Acquired white matter injury with abnormal brain microstructure and connectivity is common. 10,[16][17][18][19][20][21] Brain injury is often due to chronic or intermittent low oxygen levels in the brain, decreased brain blood flow from hypoperfusion and/or cardiac arrest, and/or reperfusion injury related to the medical and surgical therapies they have received. 5,9,[22][23][24][25] In addition, genetic contributors include associated congenital structural abnormalities of the brain as well as genetic factors associated with an increased risk for brain injury.…”

mentioning

confidence: 99%

The origins and development of the Cardiac Neurodevelopmental Outcome Collaborative: creating innovative clinical, quality improvement, and research opportunities

et al. 2020

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Compared to the general population, individuals with complex congenital heart disease are at increased risk for deficits in cognitive, neurodevelopmental, psychosocial, and physical functioning, resulting in a diminished health-related quality of life. These deficits have been well described over the past 25 years, but significant gaps remain in our understanding of the best practices to improve neurodevelopmental and psychosocial outcomes and health-related quality of life for individuals with paediatric and congenital heart disease. Innovative clinical, quality improvement, and research opportunities with collaboration across multiple disciplines and institutions were needed to address these gaps. The Cardiac Neurodevelopmental Outcome Collaborative was founded in 2016 with a described mission to determine and implement best practices of neurodevelopmental and psychosocial services for individuals and their families with paediatric and congenital heart disease through clinical, quality improvement, and research initiatives. The vision is to be a multi-centre, multi-national, multi-disciplinary group of healthcare professionals committed to working together and partnering with families to optimise neurodevelopmental outcomes for individuals with paediatric and congenital heart disease through clinical, quality, and research initiatives, intending to maximise quality of life for every individual across the lifespan. This manuscript describes the development and organisation of the Cardiac Neurodevelopmental Outcome Collaborative.

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“…4 ), which suggests that tissue abnormalities in the OR are associated with more specific neurobiological mechanisms. Because it is natural to interpret ICVF in white matter voxels as a measurement of apparent axonal density, 78 our finding may indicate that glaucoma causes axonal damage in the OR rather than myelin damage. This interpretation is also in line with a previous study demonstrating that diffusivity measurements are sensitive to Wallerian degeneration, in which axonal loss has been considered as one of the main determinants of tissue damage.…”

Section: Discussionmentioning

confidence: 79%

Multi-Contrast Magnetic Resonance Imaging of Visual White Matter Pathways in Patients With Glaucoma

Ogawa

Takemura

Horiguchi

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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Purpose Glaucoma is a disorder that involves visual field loss caused by retinal ganglion cell damage. Previous diffusion magnetic resonance imaging (dMRI) studies have demonstrated that retinal ganglion cell damage affects tissues in the optic tract (OT) and optic radiation (OR). However, because previous studies have used a simple diffusion tensor model to analyze dMRI data, the microstructural interpretation of white matter tissue changes remains uncertain. In this study, we used a multi-contrast MRI approach to further clarify the type of microstructural damage that occurs in patients with glaucoma. Methods We collected dMRI data from 17 patients with glaucoma and 30 controls using 3-tesla (3T) MRI. Using the dMRI data, we estimated three types of tissue property metrics: intracellular volume fraction (ICVF), orientation dispersion index (ODI), and isotropic volume fraction (IsoV). Quantitative T1 (qT1) data, which may be relatively specific to myelin, were collected from all subjects. Results In the OT, all four metrics showed significant differences between the glaucoma and control groups. In the OR, only the ICVF showed significant between-group differences. ICVF was significantly correlated with qT1 in the OR of the glaucoma group, although qT1 did not show any abnormality at the group level. Conclusions Our results suggest that, at the group level, tissue changes in OR caused by glaucoma might be explained by axonal damage, which is reflected in the intracellular diffusion signals, rather than myelin damage. The significant correlation between ICVF and qT1 suggests that myelin damage might also occur in a smaller number of severe cases.

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Quantification of apparent axon density and orientation dispersion in the white matter of youth born with congenital heart disease

Cited by 23 publications

References 61 publications

Microstructural alterations of the corticospinal tract are associated with poor motor function in patients with severe congenital heart disease

Microstructural alterations of the corticospinal tract are associated with poor motor function in patients with severe congenital heart disease

The origins and development of the Cardiac Neurodevelopmental Outcome Collaborative: creating innovative clinical, quality improvement, and research opportunities

Multi-Contrast Magnetic Resonance Imaging of Visual White Matter Pathways in Patients With Glaucoma

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