Quantification of bone marrow edema in rheumatoid arthritis by using high-speed T2-corrected multiecho acquisition of 1H magnetic resonance spectroscopy: a feasibility study

Yuan, Wenzhao; Lei, Yiwu; Tang, Cheng; Qin, Fang; Wen, Jing; Li, Chenhui; Ling, Min; Huang, Jian; Zhang, Huiting

doi:10.1007/s10067-021-05764-x

Cited by 3 publications

(3 citation statements)

References 47 publications

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“…1 H-MRS spectroscopy provides concentrations of specific metabolites, and its main application in marrow imaging is the quantification of fat. 36 103 In clinical research, it has been investigated in a few applications related to osteoporosis, fracture risk assessment, and response to treatment in patients with metabolic diseases like anorexia nervosa, 104 105 Gaucher's disease, 106 rheumatoid arthritis, 107 multiple myeloma, 108 or Charcot's neuroarthropathy. 109 However, in clinical practice, its use has significantly decreased in favor of CSI.…”

Section: Other Techniques Of Marrow Imaging Using Mrimentioning

confidence: 99%

Advances in Bone Marrow Imaging: Strengths and Limitations from a Clinical Perspective

Mourad

Cosentino

Lalonde

et al. 2023

Semin Musculoskelet Radiol

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Conventional magnetic resonance imaging (MRI) remains the modality of choice to image bone marrow. However, the last few decades have witnessed the emergence and development of novel MRI techniques, such as chemical shift imaging, diffusion-weighted imaging, dynamic contrast-enhanced MRI, and whole-body MRI, as well as spectral computed tomography and nuclear medicine techniques. We summarize the technical bases behind these methods, in relation to the common physiologic and pathologic processes involving the bone marrow. We present the strengths and limitations of these imaging methods and consider their added value compared with conventional imaging in assessing non-neoplastic disorders like septic, rheumatologic, traumatic, and metabolic conditions. The potential usefulness of these methods to differentiate between benign and malignant bone marrow lesions is discussed. Finally, we consider the limitations hampering a more widespread use of these techniques in clinical practice.

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Section: Other Techniques Of Marrow Imaging Using Mrimentioning

confidence: 99%

Advances in Bone Marrow Imaging: Strengths and Limitations from a Clinical Perspective

Mourad

Cosentino

Lalonde

et al. 2023

Semin Musculoskelet Radiol

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“…One is water-fat separation based and another is proton magnetic resonance spectroscopy ( 1 H MRS) based. Various MRI techniques, commonly recognized in the field as quantitative Dixon (Q-Dixon) ( 21 ) for water-fat separation and high-speed T 2 -corrected multi-echo (HISTO) ( 22 ) for 1 H MRS respectively, facilitate noninvasive reproducible examination and quantitative measurement of fat proportion in the liver ( 22 , 23 ), bone ( 21 ), bone marrow ( 24 ) and muscle ( 25 , 26 ). Both methods quantify volumetric tissue fat in terms of proton density fat fraction (PDFF), defined as the ratio of the signal strength from fat to the total signal from fat and water ( 27 , 28 ).…”

Section: Introductionmentioning

confidence: 99%

Quantification of volumetric thigh and paravertebral muscle fat content: comparison of quantitative Dixon (Q-Dixon) magnetic resonance imaging (MRI) with high-speed T2-corrected multiecho MR spectroscopy

Zhang,

Fu,

Yan

et al. 2024

Quant Imaging Med Surg

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Background Muscle fat infiltration (MFI) is increasingly recognized as a critical factor influencing muscle function and metabolic health. Accurate quantification of MFI is essential for diagnosing and monitoring various muscular and metabolic disorders. Quantitative Dixon (Q-Dixon) magnetic resonance imaging (MRI) and high-speed T 2 -corrected multi-echo (HISTO) magnetic resonance spectroscopy (MRS) are both advanced imaging techniques that offer potential for detailed assessment of MFI. However, the validity and reliability of these methods in measuring volumetric changes in muscle composition, particularly in both thigh and paravertebral muscles, have not been thoroughly compared. This study aims to validate volumetric measurements using Q-Dixon MRI against HISTO MRS in thigh and paravertebral muscles, taking into account the heterogeneity of MFI. Methods A retrospective study was conducted with 54 subjects [mean age, 60 years; 38 male (M)/16 female (F)] for thigh muscle and 56 subjects (mean age, 50 years; 22 M/34 F) for paravertebral muscle assessment using a 3-Tesla MRI. The proton density fat fraction (PDFF) was measured with Q-Dixon MRI and HISTO MRS within the upper-middle part of quadriceps femoris and paravertebral muscles at L4/5 level in volumes-of-interest (VOIs). The corresponding volumetric Q-Dixon freehand VOI PDFF was measured. Scatterplots, Bland-Altman plots, Spearman correlation coefficients, and Wilcoxon signed rank test with Bonferroni correction were employed. The Kruskal-Wallis H tests followed by Bonferroni-corrected post hoc tests were analyzed to compare parameter differences with visual MFI grades. Results Q-Dixon cubic VOI PDFF correlated positively with HISTO MRS PDFF in thigh (r=0.96, P<0.001) and paravertebral groups (r=0.98, P<0.001), with insignificant differences (P=0.29, 0.82, respectively). Both PDFF values from cubic VOIs in Q-Dixon and HISTO MRS differed from the freehand Q-Dixon PDFF (all P<0.001). Only for <5% HISTO MRS PDFF, there was a difference between HISTO MRS PDFF and Q-Dixon cubic VOI PDFF (P=0.002). Conclusions Volumetric Q-Dixon cubic VOI PDFF exhibited good correlation and consistency with HISTO MRS PDFF for quantitative fat assessment in thigh and paravertebral muscles except for muscles with fat fraction <5%, and the Q-Dixon freehand VOI PDFF offers a more comprehensive assessment of the actual MFI compared to cubic VOI.

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“…The key biophysical mechanisms for this hyperintensity are thought to be an increase in proportional water content, with an accompanying reduction in fat content, and elongation of the T 2 of the water component (T 2water ). 7,[8][9][10][11][12] In the rheumatic inflammatory diseases, the identification of STIR hyperintensity is crucial for the detection of inflammation, and thus plays a key role in the patient pathway.…”

Section: Introductionmentioning

confidence: 99%

A multiparametric alternative to short inversion‐time inversion recovery for imaging inflammation: T_2water and fat fraction measurement using chemical shift–encoded turbo spin‐echo MRI

Gollifer

Bray

Kruezi

et al. 2023

Magnetic Resonance in Med

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Short-inversion-time inversion-recovery MRI is used widely for imaging bone and soft-tissue inflammation in rheumatic inflammatory diseases, but there is no widely available quantitative equivalent of this sequence. This limits our ability to objectively assess inflammation and distinguish it from other processes. To address this, we investigate the use of the widely available Dixon turbo spin echo (TSE Dixon) sequence as a practical approach to simultaneous water-specific T 2 (T 2water ) and fat fraction (FF) measurement. Methods:We use a series of TSE Dixon acquisitions with varying effective TEs (TE eff ) to quantify T 2water and FF. The validity of this approach is assessed in a series of phantom and in vivo experiments, with reference values provided by Carr-Purcell-Meiboom-Gill acquisitions, MRS, and phantoms. The effect of inflammation on parameter values is evaluated in patients with spondyloarthritis.

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Quantification of bone marrow edema in rheumatoid arthritis by using high-speed T2-corrected multiecho acquisition of 1H magnetic resonance spectroscopy: a feasibility study

Cited by 3 publications

References 47 publications

Advances in Bone Marrow Imaging: Strengths and Limitations from a Clinical Perspective

Advances in Bone Marrow Imaging: Strengths and Limitations from a Clinical Perspective

Quantification of volumetric thigh and paravertebral muscle fat content: comparison of quantitative Dixon (Q-Dixon) magnetic resonance imaging (MRI) with high-speed T2-corrected multiecho MR spectroscopy

A multiparametric alternative to short inversion‐time inversion recovery for imaging inflammation: T_2water and fat fraction measurement using chemical shift–encoded turbo spin‐echo MRI

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Quantification of bone marrow edema in rheumatoid arthritis by using high-speed T2-corrected multiecho acquisition of 1H magnetic resonance spectroscopy: a feasibility study

Cited by 3 publications

References 47 publications

Advances in Bone Marrow Imaging: Strengths and Limitations from a Clinical Perspective

Advances in Bone Marrow Imaging: Strengths and Limitations from a Clinical Perspective

Quantification of volumetric thigh and paravertebral muscle fat content: comparison of quantitative Dixon (Q-Dixon) magnetic resonance imaging (MRI) with high-speed T2-corrected multiecho MR spectroscopy

A multiparametric alternative to short inversion‐time inversion recovery for imaging inflammation: T2water and fat fraction measurement using chemical shift–encoded turbo spin‐echo MRI

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Product

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A multiparametric alternative to short inversion‐time inversion recovery for imaging inflammation: T_2water and fat fraction measurement using chemical shift–encoded turbo spin‐echo MRI