1999
DOI: 10.1111/j.1600-0897.1999.tb00446.x
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Quantification of C3 and C4 in Infertile Men with Antisperm Antibody in Their Seminal Plasma

Abstract: In the presence of ASAs, the C system has no definitive activity in blood serum or outside the male genital tract. In SP, and in association with ASAs, C has no lytic activity by the classical pathway. The excess of C3 in SP of ASA+ infertile men may participate in other C-mediated activities in the male reproductive tract.

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Cited by 17 publications
(14 citation statements)
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“…The role of complement in semen was strongly suggested by the observation that infection with HIV added to heated or EDTA-treated semen was no different from that seen with HIV alone (i.e., diluted in culture medium). Complement components have been detected in all body secretions, including seminal fluid (4,5). HIV is known to activate complement in serum in the presence or the absence of Abs (12,19).…”
Section: Discussionmentioning
confidence: 99%
“…The role of complement in semen was strongly suggested by the observation that infection with HIV added to heated or EDTA-treated semen was no different from that seen with HIV alone (i.e., diluted in culture medium). Complement components have been detected in all body secretions, including seminal fluid (4,5). HIV is known to activate complement in serum in the presence or the absence of Abs (12,19).…”
Section: Discussionmentioning
confidence: 99%
“…The action of antibody on endothelial cells in the absence of complement activation also may have a role in allograft rejection, particularly chronic allograft rejection (50). Even in the absence of complement, endothelial cells demonstrate activation and proliferation in the presence of MHC class I antibodies in vitro (51,52).…”
Section: Antibody Action Without Complementmentioning
confidence: 99%
“…Semen, cervicovaginal secretions, and breast milk contain complement proteins that may allow viral particles to be opsonized (3)(4)(5). Opsonization of HIV-1 with complement results in enhancement of viral infection of T and B cell lines (6,7), primary PBMC (8), and primary monocytes/ macrophages (9).…”
mentioning
confidence: 99%