2019
DOI: 10.1007/978-981-13-8367-0_10
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Quantification of Mitochondrial Network Characteristics in Health and Disease

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Cited by 13 publications
(16 citation statements)
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“…The reasons for that are not clear, one of possible explanation is different composition of culture media, including different glucose concentration, which is known to strongly affect mitochondrial network morphology of the cultured cells. 35 The results from our analysis of the mitochondrial size distribution are in line with those reported by Perez et al 20 We detected a higher percentage of the smallest mitochondria and fewer individual mitochondria per cell in AD fibroblasts. Thus, when looking only at the size of the elements separated from the network, one may assume enhanced mitochondrial fission.…”
Section: Discussionsupporting
confidence: 92%
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“…The reasons for that are not clear, one of possible explanation is different composition of culture media, including different glucose concentration, which is known to strongly affect mitochondrial network morphology of the cultured cells. 35 The results from our analysis of the mitochondrial size distribution are in line with those reported by Perez et al 20 We detected a higher percentage of the smallest mitochondria and fewer individual mitochondria per cell in AD fibroblasts. Thus, when looking only at the size of the elements separated from the network, one may assume enhanced mitochondrial fission.…”
Section: Discussionsupporting
confidence: 92%
“…The importance of mitochondrial network morphology, which translates into their functionality, is increasingly explored. 35 However, its research is often based only F I G U R E 4 Mitochondrial dynamics in control and sAD fibroblasts. A, Representative images showing the alterations in the mitochondrial size and quantity of separate fragments of mitochondrial network observed during the analysis.…”
Section: Discussionmentioning
confidence: 99%
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“…In cells, mitochondria can exist as either punctate, individual mitochondria or branched, highly connected architectures (Bleck et al, 2018;Valente et al, 2019) termed the mitochondrial network or reticulum (Figure 3). For example, mitochondria in vascular smooth muscles are ovoid or rod-shaped (Nixon et al, 1994;McCarron et al, 2013).…”
Section: Mitochondrial Network Structurementioning
confidence: 99%
“…However, Morton et al also demonstrated a significantly higher maximal respiration capacity of lymphocytes from healthy individuals compared with lymphocytes from acute pancreatitis patients with a simultaneously unchanged basal oxygen consumption [36]. We suggest TGF-ß1 activates a program that increases the maximal respiratory potential of mitochondria, possibly due to mitochondrial mass or architecture, improved fission and fusion, and/or altered reactive oxygen species concentrations [37].…”
Section: Discussionmentioning
confidence: 61%