Quantification of olanzapine polymorphs using powder X-ray diffraction technique

Tiwari, Manisha; Chawla, Garima; Bansal, Arvind K.

doi:10.1016/j.jpba.2006.08.030

Cited by 90 publications

(55 citation statements)

References 15 publications

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“…67, 17.09, 19.87, 21.05, 21.54, and 23.95 which were identical to those reported in the literature (Tiwari et al, 2007). The XRD pattern for ascorbic acid also showed multiple sharp characteristic diffraction lines at 2 10.…”

Section: X-ray Diffractionsupporting

confidence: 86%

In vitro/in vivo evaluation of an optimized fast dissolving oral film containing olanzapine co-amorphous dispersion with selected carboxylic acids

et al. 2016

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Improvement of water solubility, dissolution rate, oral bioavailability, and reduction of first pass metabolism of OL (OL), were the aims of this research. Co-amorphization of OL carboxylic acid dispersions at various molar ratios was carried out using rapid solvent evaporation. Characterization of the dispersions was performed using differential scanning calorimetry (DSC), Fourier transform infrared spectrometry (FTIR), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). Dispersions with highest equilibrium solubility were formulated as fast dissolving oral films. Modeling and optimization of film formation were undertaken using artificial neural networks (ANNs). The results indicated co-amorphization of OL-ascorbic acid through H-bonding. The co-amorphous dispersions at 1:2 molar ratio showed more than 600-fold increase in solubility of OL. The model optimized fast dissolving film prepared from the dispersion was physically and chemically stable, demonstrated short disintegration time (8.5 s), fast dissolution (97% in 10 min) and optimum tensile strength (4.9 N/cm 2 ). The results of in vivo data indicated high bioavailability (144 ng h/mL) and maximum plasma concentration (14.2 ng/mL) compared with the marketed references. Therefore, the optimized co-amorphous OL-ascorbic acid fast dissolving film could be a valuable solution for enhancing the physicochemical and pharmacokinetic properties of OL.

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Section: X-ray Diffractionsupporting

confidence: 86%

In vitro/in vivo evaluation of an optimized fast dissolving oral film containing olanzapine co-amorphous dispersion with selected carboxylic acids

et al. 2016

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“…Many APIs can transform into different polymorphic forms from an amorphous state [156]. Thus, reference powder patterns for that API makes the identification of different polymorphs possible [157][158][159]. The preferred orientation of crystals is considered to be the main source of error in PXRD experiments, but this can be minimized using transmission mode analysis [160].…”

Section: X-ray Diffraction Techniquesmentioning

confidence: 99%

Pharmaceutical solvates, hydrates and amorphous forms: A special emphasis on cocrystals

Healy

Worku

Kumar

et al. 2017

Advanced Drug Delivery Reviews

282

189

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a b s t r a c t a r t i c l e i n f oActive pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to differences in the intermolecular interactions, affecting the internal energy and enthalpy, and the degree of disorder, affecting the entropy. Differences in solid forms often lead to differences in thermodynamic parameters and physicochemical properties for example solubility, dissolution rate, stability and mechanical properties of APIs and excipients. Hence, solid forms of APIs play a vital role in drug discovery and development in the context of optimization of bioavailability, filing intellectual property rights and developing suitable manufacturing methods. In this review, the fundamental characteristics and trends observed for pharmaceutical hydrates, solvates and amorphous forms are presented, with special emphasis, due to their relative abundance, on pharmaceutical hydrates with single and two-component (i.e. cocrystal) host molecules.

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“…The diffraction patterns of amorphous solids consist of broad peaks often referred to as an amorphous halo because amorphous systems have little long-range order. 28 Metformin displayed crystallinity by showing peaks at 2 of 12,13,18,22,24,25,32,34. Similar peaks were produced by the microsphere formulations but with significantly reduced intensity.…”

Section: Drug-polymer Interactionmentioning

confidence: 99%

Evaluation of two novel plant gums for bioadhesive microsphere and sustained-release formulations of metformin hydrochloride

2017

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Quantification of olanzapine polymorphs using powder X-ray diffraction technique

Cited by 90 publications

References 15 publications

In vitro/in vivo evaluation of an optimized fast dissolving oral film containing olanzapine co-amorphous dispersion with selected carboxylic acids

In vitro/in vivo evaluation of an optimized fast dissolving oral film containing olanzapine co-amorphous dispersion with selected carboxylic acids

Pharmaceutical solvates, hydrates and amorphous forms: A special emphasis on cocrystals

Evaluation of two novel plant gums for bioadhesive microsphere and sustained-release formulations of metformin hydrochloride

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