Quantification of plasma Epstein–Barr virus DNA for assessing treatment response in a patient with plasmablastic lymphoma

Law, Man Fai; Poon, Wai Lun; Ng, Kwan Shun; Chan, Hay Nun; Lai, Ho Kei; Ha, Chung Yin; Ng, Chi‐Fai; Yeung, Yiu Ming; Yip, Sze Fai

doi:10.1007/s00277-011-1313-1

Cited by 7 publications

(6 citation statements)

References 11 publications

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“…Hence, it plays a significant role in the tumorigenesis in HIV-positive PBL patients [ 2 , 11 – 14 ]. Apart from the role of EBV as an effective diagnostic marker, it has also been implicated in investigating potential EBV-directed PBL therapies and predicting treatment response and relapse in PBL cases [ 15 – 17 ].…”

Section: Discussionmentioning

confidence: 99%

Plasmablastic Lymphoma Mimicking Acute Pancreatitis

Inayat

Virk

Cheema

et al. 2016

Case Reports in Oncological Medicine

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Background. Plasmablastic lymphoma (PBL) is a rare B-cell neoplasm. It predominantly occurs in the oral cavity of human immunodeficiency virus (HIV)-positive patients and exhibits a highly aggressive clinical behavior. Case Presentation. We describe an unusual case of a 37-year-old HIV-positive male who presented with acute pancreatitis secondary to multiple peripancreatic masses compressing the pancreas. Histopathological examination of the lesions showed diffuse and cohesive pattern of large B-cells resembling immunoblasts or plasmablasts. The neoplastic cells were positive for BOB1 and MUM1, partially positive for CD79a, and negative for CD20, CD56, CD138, CD3, CD5, AE1/AE3, and HHV8. Epstein-Barr virus-encoded RNA in situ hybridization was positive. These features were consistent with PBL. The patient was initiated on cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy, demonstrating a striking response. Conclusion. To our research, this is the first report of PBL with the initial presentation of acute pancreatitis. The findings in this case suggest that PBL should be included in the differential diagnosis of pancreatic and peripancreatic tumors.

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Section: Discussionmentioning

confidence: 99%

Plasmablastic Lymphoma Mimicking Acute Pancreatitis

Inayat

Virk

Cheema

et al. 2016

Case Reports in Oncological Medicine

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“…Quantification of the plasma EBV-DNA level may facilitate the monitoring of treatment response and it has been found to be effective in different types of lymphoproliferative diseases (13)(14)(15). For cases responding to treatment, circulating EBV-DNA falls to undetectable levels when complete remission is achieved (13).…”

Section: Discussionmentioning

confidence: 99%

Post-transplant lymphoproliferative disorder presenting with skin ulceration in a renal transplant recipient who achieved sustained remission with rituximab therapy: A case report

Law

Chan

Lai

et al. 2016

Molecular and Clinical Oncology

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Abstract. Post-transplant lymphoproliferative disorder (PTLD) is associated with a variety of clinical presentations, but rarely involves the skin. We herein report a case of PTLD presenting with skin ulceration in a renal transplant recipient. A biopsy of the ulcer confirmed the diagnosis of diffuse large B-cell lymphoma. The patient was initially treated with immunosuppression reduction, but the skin ulcer persisted. He was then treated with two courses of chemotherapy, but his condition was complicated with cryptococcal infection. Antifungal agents were administered to control the fungal infection. The patient later developed lymphoma recurrence and was successfully treated with single-agent rituximab. The patient remains well 6 years after treatment, with no evidence of disease relapse. Therefore, PTLD may manifest as skin lesions and physicians must be aware of this rare presentation.

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“…HAART has been defined as a modifying factor of PL’s natural course, as its use is associated with an increase of extra oral PL presentation. [ 1 , 2 , 4 - 10 ].…”

Section: Discussionmentioning

confidence: 99%

Rectal Plasmablastic Lymphoma in HIV/AIDS: Two Cases

et al. 2013

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Plasmablastic lymphoma is an aggressive variant of large B-cells lymphoma in which the infection by Human Immunodeficiency Virus and Epstein-Barr herpesvirus are involved. This recently denominated neoplasia has a special tropism through the oral cavity. However, its presence has been reported in the digestive tract, abdominal cavity and retroperitoneum. We describe two Human Immunodeficiency Virus infected patient cases with rectal presentation of PL in the HIV service of the Hospital Civil de Guadalajara.

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Quantification of plasma Epstein–Barr virus DNA for assessing treatment response in a patient with plasmablastic lymphoma

Cited by 7 publications

References 11 publications

Plasmablastic Lymphoma Mimicking Acute Pancreatitis

Plasmablastic Lymphoma Mimicking Acute Pancreatitis

Post-transplant lymphoproliferative disorder presenting with skin ulceration in a renal transplant recipient who achieved sustained remission with rituximab therapy: A case report

Rectal Plasmablastic Lymphoma in HIV/AIDS: Two Cases

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