Quantification of the selective retention of palladium octabutoxynaphthalocyanine, a potential photothermal drug, in mouse tissues

Bucking, M.; Dickson, Eva F. Gudgin; Farahani, M.; Fischer, F.; Holmes, Duncan S.; Jori, Giulio; Kennedy, James C.; Kenney, Malcolm E.; Peng, X.; Pottier, R.; Weagle, G.

doi:10.1016/s1011-1344(00)00108-1

Cited by 15 publications

(18 citation statements)

References 18 publications

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“…PdNc(OBu) 8 has a limited solubility in most potential injectable solutions. For injection, a Cremophor EL ® /propylene glycol‐based delivery formulation was used, which was freshly prepared prior to each injection, according to the description of Bucking and coworkers . In brief: 5 ml Cremophor EL was heated to 55°C to which 1.65 ml of propylene glycol was added dropwise.…”

Section: Methodsmentioning

confidence: 99%

“…Tetrahydrofuran was evaporated by heat (55°C), and the sample was diluted 1:1 by volume with sterile saline. The naphthalocyanine concentration was determined spectrophotometrically during this procedure using an extinction coefficient of 280,000 M −1 cm −1 at 828 nm in tetrahydrofuran, and 295,000 M −1 cm −1 in the injection formulation .…”

Section: Methodsmentioning

confidence: 99%

“…A study on the pharmacokinetic behavior of PdNc(OBu) 8 , performed by our group in a Balb/c‐EMT6 tumor model revealed good selective accumulation in tumor tissue compared to, for example, muscle and skin at 96 hours post intraperitoneal application of the dye, with ratios of 20:1 (tumor:muscle) and 5:1 (tumor:skin), respectively .…”

Section: Introductionmentioning

confidence: 99%

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Localized thermal tumor destruction using dye‐enhanced photothermal tumor therapy

et al. 2015

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Localized thermal tumor destruction using dye‐enhanced photothermal tumor therapy

et al. 2015

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“…However, the metal complexes studied thus far have mostly been limited to the first row transition metal complexes. Although the synthesis of Ru and Os Nc(OBu) 8 complexes was reported recently [15], only PdNc(OBu) 8 has been studied for its photophysical and photochemical properties from the second and third row transition metals [10, 11]. …”

Section: Introductionmentioning

confidence: 99%

The synthesis and characterization of a group of transition metal octabutoxynaphthalocyanines and the absorption and emission properties of the Co, Rh, Ir, Ni, Pd and Pt members of this group

Kim¹,

Soldatova²,

Rodgers³

et al. 2013

Polyhedron

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The synthesis and photophysical properties of new metallo-octabutoxynaphthalocyanines with Rh(III), Ir(III), and Pt(II) are reported. Various metals were inserted into the metal-free octabutoxynaphthalocyanine and the resultant metal complexes were fully characterized by NMR, UV-vis spectroscopy, and mass spectrometry. The absorption and emission properties of these new complexes were also examined and compared to those of Co(II), Ni(II), and Pd(II) octabutoxynaphthalocyanines. The results provide useful information to understand the effect of these transition metals on the properties of this macrocyclic ring.

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“…Octabutoxynaphthalocyanines (H 2 Nc(OBu) 8 ) of the elements iron [1], cobalt [2], nickel [3], copper [4,5], zinc [4], and palladium [6,7] have been reported. However, little is known about iron octabutoxynaphthalocyanines and nothing is known about the ruthenium and osmium octabutoxynaphthalocyanines.…”

Section: Introductionmentioning

confidence: 99%

The synthesis and properties of iron, ruthenium, and osmium octabutoxynaphthalocyanine

Kim

Kenney

2012

J. Porphyrins Phthalocyanines

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New series of iron, ruthenium, and osmium octabutoxynaphthalocyanines were synthesized by inserting corresponding metals into the metal-free octabutoxynaphthalocyanine. Although preparation of axial ligand-free iron octabutoxynaphthalocyanines was reported before, we could not reproduce the synthesis by following the reported method. We attributed the failure to the instability of the iron octabutoxynaphthalocyanines. Bis-ligation increased the stability of the iron complex but only sufficiently for characterization. The application of iron complexes will be limited by their instability. However, ruthenium and osmium formed stable complexes with this macrocycle ring but with significantly lower reaction yields. These new complexes were characterized by NMR, UV-vis, and mass spectrometry.

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Quantification of the selective retention of palladium octabutoxynaphthalocyanine, a potential photothermal drug, in mouse tissues

Cited by 15 publications

References 18 publications

Localized thermal tumor destruction using dye‐enhanced photothermal tumor therapy

Localized thermal tumor destruction using dye‐enhanced photothermal tumor therapy

The synthesis and characterization of a group of transition metal octabutoxynaphthalocyanines and the absorption and emission properties of the Co, Rh, Ir, Ni, Pd and Pt members of this group

The synthesis and properties of iron, ruthenium, and osmium octabutoxynaphthalocyanine

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