Quantification of the uterine involution and dimensions, hormonal response and reproductive performance of pyometric and healthy dairy cows treated with Dinoprost

Abstract

The aim of the present study was to investigate the effects of a PGF 2α analogue (Dinoprost) on involution of the puerperal uterus, especially with pyometra during 35 to 45 days postpartum in multiparous high yielding Holstein dairy cows. At days 40 ± 5 postpartum, 1250 cows were ultrasonographically examined. Fifty cows were diagnosed as pyometric. Fifty pyometric and 50 clinically healthy cows were assigned randomly to one of four groups. Groups were: 1.) Pyometric+Dinoprost cows (PD, n = 25 treated with 25 mg of Dinoprost), 2.) Pyometric+Saline cows (PS, n = 25 treated with saline), 3.) Healthy+Dinoprost cows (HD, n = 25 treated with 25 mg of Dinoprost), and 4.) Healthy+Saline cows (HS, n = 25 treated with saline). All treatments were given intramuscularly. Ultrasonography was performed at the time of examination and 7 days later to evaluate changes in uterine diameter. Treatment with Dinoprost significantly reduced gross uterine diameter in PD in comparison to the PS group in the presence or absence (P4 concentrations <1 ng/ml) of an active corpus luteum. Dinoprost treatment did not decrease gross uterine diameter in groups HD and HS. Luminal diameter was significantly smaller in the PD than in the PS group. Pregnancy rate of PD was greater than PS cows (36% vs 20%, respectively). Days to first service (110 d vs. 140 d) and open days (160 d vs. 190 d) were shorter in PD cows than PS cows. It was concluded that injection of 25 mg of Dinoprost to pyometric cows had uterotonic effects in presence or absence of functional corpus luteum. Therefore, this treatment can help uterine involution in puerperal dairy cows affected by pyometra and consequently improved reproductive performance.

Treatment of Postpartum Metritis in Dairy Cattle

“…It has been reported that the PGF 2 α the most effective drug for metritis (19), while others showed no improvement of the subclinical metritis (20,21) . It has been observed that administration of 25 mg/im of Dinoprost (synthetic PGF 2 α) had an effect on reduction of the size of the uterus (22) . The low response in T 1 and T 2 which treated with lugol's Iodine and Lotagen respectively it might be due to that intrauterine infusions treated with these antiseptics leads to irritation and necrosis of endometrial wall and may cause damages to the endometrial glands.…”

Effect of Exogenous Progesterone or Flunixin Meglumine After AI on Serum Progesterone Concentration and Pregnancy per AI in Lactating Dairy Cows

“…Estrus detection was performed by two technicians every 3 h for at least 20 min during each observation. Estrus was confirmed by transrectal palpation before AI as previously described (López-Gatius and Camón-Urgel, 1991;Masoumi et al, 2018). Cows confirmed in estrus were inseminated, according to the am/pm rule, with semen from sires available commercially.…”

IMPACT OF OXYTETRACYCLINE AND PROSTAGLANDIN F2α DURING PUERPERIUM PERIOD ON UTERINE RECOVERY AND POST-PARTURIENT REPRODUCTIVE CHARACTERISTICS IN BALADI COWS

“…Melendez et al (2004) reported that at 8 d postpartum, two doses of PGF2α 8 h apart in primiparous Holstein cows diminished the diameter of the uterine horns. Masoumi et al (2018) observed that 25mg PGF2α injection led to uterotonic effects, which may aid accelerate uterine involution in puerperal dairy cows. PGF2α is commonly used during early postpartum to facilitate uterine involution in dairy cows (Salasal andMokhtari, 2011 andJeremejeva et al, 2012).…”