2022
DOI: 10.55519/jamc-02-9698
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Quantification of Thrombus Burden as an Independent Predictor of Intra-Procedural No-Reflow in Patients With St-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Revascularization

Abstract: Background: Aim of this study was to perform quantitative evaluation of high thrombus burden (Grade ≥4) as an independent predictor of slow/no reflow phenomenon during primary percutaneous coronary interventions (PCI) of patients with ST-segment elevation myocardial infarction (STEMI). Methods: In this analytical cross-sectional study we included consecutive patients who have undergone primary PCI for STEMI at a tertiary care cardiac center of the Pakistan. High thrombus burden was defined as angiographic thro… Show more

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Cited by 10 publications
(7 citation statements)
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“…1 High thrombus burden and plaque rupture, the two main pathogenesis, are associated with poor myocardial reperfusion with increased risk of slow/no-reflow during primary PCI. 2 Manual thrombus aspiration or pre-balloon dilatation after passing the coronary wire are the two widely adopted clinical approaches for primary PCI of patients with thrombolysis in myocardial infarction (TIMI) flow grade of 0. However, routine manual thrombus aspiration is downgraded from class IIa to class III in the current clinical practice guidelines.…”
Section: Introductionmentioning
confidence: 99%
“…1 High thrombus burden and plaque rupture, the two main pathogenesis, are associated with poor myocardial reperfusion with increased risk of slow/no-reflow during primary PCI. 2 Manual thrombus aspiration or pre-balloon dilatation after passing the coronary wire are the two widely adopted clinical approaches for primary PCI of patients with thrombolysis in myocardial infarction (TIMI) flow grade of 0. However, routine manual thrombus aspiration is downgraded from class IIa to class III in the current clinical practice guidelines.…”
Section: Introductionmentioning
confidence: 99%
“…High-burden thrombosis is the most important risk factor for no reflow or slow blood flow phenomena following PCI ( 32 ). Thrombus aspiration (TA) is a common method used for treating intracoronary thrombus, but TA cannot completely remove the thrombus and no reflow rate is still high following emergency PCI ( 33 ).…”
Section: Discussionmentioning
confidence: 99%
“…The thrombus load in the infarct-related artery was scored using the TIMI thrombus grade. This grading system included six categories, ranging from no cineangiography characteristics of thrombus present (TIMI grade 0) to chronic total occlusion with extensive collateralization (TIMI grade 6) (9) .…”
Section: Exclusion Criteriamentioning
confidence: 99%