Quantifying Bioaccumulation in the Aquatic Environment

Borgå, Katrine; Ruus, Anders

doi:10.1007/7653_2019_36

Cited by 4 publications

(4 citation statements)

References 41 publications

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“…We estimated TMFs by regressing the PFAS concentrations onto the TP for Svarthamaren, as it was the only colony where we had three trophic levels (Borgå et al, 2012;Kidd et al, 2019). The corresponding equations can be found in Borgå and Ruus (2019) and in Supporting Information.…”

Section: Biomagnification and Trophic Magnification Factorsmentioning

confidence: 99%

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Bioaccumulation of Per and Polyfluoroalkyl Substances in Antarctic Breeding South Polar Skuas (Catharacta maccormicki) and Their Prey

Garcia¹,

Descamps

Herzke

et al. 2022

Front. Mar. Sci.

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Per and polyfluoroalkyl substances (PFASs) are found in Antarctic wildlife, with high levels in the avian top predator south polar skua (Catharacta maccormicki). As increasing PFAS concentrations were found in the south polar skua during the breeding season in Antarctica, we hypothesised that available prey during the breeding period contributes significantly to the PFAS contamination in skuas. To test this, we compared PFAS in south polar skuas and their main prey from two breeding sites on opposite sides of the Antarctic continent: Antarctic petrel (Thalassoica antarctica) stomach content, eggs, chicks, and adults from Svarthamaren in Dronning Maud Land and Adélie penguin chicks (Pygoscelis adeliae) from Dumont d’Urville in Adélie Land. Of the 22 PFAS analysed, seven were present in the majority of samples, except petrel stomach content [only perfluoroundecanoate (PFUnA) present] and Adélie penguins (only four compounds present), with increasing concentrations from the prey to the skuas. The biomagnification factors (BMFs) were higher at Dumont d’Urville than Svarthamaren. When adjusted to reflect one trophic level difference, the BMFs at Svarthamaren remained the same, whereas the ones at Dumont d’Urville doubled. At both the colonies, the skua PFAS pattern was dominated by perfluorooctanesulfonic acid (PFOS), followed by PFUnA, but differed with the presence of branched PFOS and perfluorotetradecanoate (PFTeA) and lack of perfluorononanoate (PFNA) and perfluorodecanoate (PFDA) at Dumont d’Urville. At Svarthamaren, the pattern in the prey was comparable to the skuas, but with a higher relative contribution of PFTeA in prey. At Dumont d’Urville, the pattern in the prey differed from the skuas, with the domination of PFUnA and the general lack of PFOS in prey. Even though the PFAS levels are low in Antarctic year-round resident prey, the three lines of evidence (pattern, BMF difference, and BMF adjusted to one trophic level) suggest that the Antarctic petrel are the significant source of PFAS in the Svarthamaren skuas, whereas the skuas in Dumont d’Urville have other important sources to PFAS than Adélie penguin, either in the continent or external on the inter-breeding foraging grounds far from Antarctica.

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Section: Biomagnification and Trophic Magnification Factorsmentioning

confidence: 99%

“…Diet is the major source of PFAS in avian wildlife and biomagnification factors (BMFs) reflect the relative change in contaminant concentration from prey to predator (Mackay et al, 2013;Borgå and Ruus, 2019). BMF is assumed to reflect a steady state condition where the predator reflects the contaminant status in its dominant prey.…”

Section: Introductionmentioning

confidence: 99%

Bioaccumulation of Per and Polyfluoroalkyl Substances in Antarctic Breeding South Polar Skuas (Catharacta maccormicki) and Their Prey

Garcia¹,

Descamps

Herzke

et al. 2022

Front. Mar. Sci.

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“…The BCF of a chemical represents the concentration ratio between the organism in vivo and water at a steady state. 33,34 Because pharmaceuticals are regarded as pseudo-persistent pollutants, bioconcentration can rise to a toxic level within the organism over time. Therefore, BCF is an important endpoint in assessing the hazard potential of a compound in an aquatic environment.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Bioconcentration in fish is a process in which a compound is taken up by the gills, dermal contact, and oral intake, and its concentration subsequently increases in the body tissue. The BCF of a chemical represents the concentration ratio between the organism in vivo and water at a steady state. , Because pharmaceuticals are regarded as pseudo-persistent pollutants, bioconcentration can rise to a toxic level within the organism over time. Therefore, BCF is an important endpoint in assessing the hazard potential of a compound in an aquatic environment.…”

Section: Resultsmentioning

confidence: 99%

Enantiospecific Uptake and Depuration Kinetics of Chiral Metoprolol and Venlafaxine in Marine Medaka (Oryzias melastigma): Tissue Distribution and Metabolite Formation

Jin

Wang

Meng

et al. 2023

Environ. Sci. Technol.

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The increasing use of chiral pharmaceuticals has led to their widespread presence in the environment. However, their toxicokinetics have rarely been reported. Therefore, the tissue-specific uptake and depuration kinetics of two pairs of pharmaceutical enantiomers, S-(−)-metoprolol versus R-(+)-metoprolol and S-(+)-venlafaxine versus R-(−)-venlafaxine, were studied in marine medaka (Oryzias melastigma) during a 28-day exposure and 14-day clearance period. The toxicokinetics of the studied pharmaceuticals, including uptake and depuration rate constants, depuration half-life (t 1/2 ), and bioconcentration factor (BCF), were reported for the first time. The whole-fish results demonstrated a higher S-than Rvenlafaxine bioaccumulation potential, whereas no significant difference was observed between S-and R-metoprolol. O-desmethyl-metoprolol (ODM) and α-hydroxy-metoprolol (AHM) were the main metoprolol metabolites identified by suspect screening, and the ratios of ODM to AHM were 3.08 and 1.35 for S-and R-metoprolol, respectively. N,O-Didesmethyl-venlafaxine (NODDV) and Ndesmethyl-venlafaxine (NDV) were the main venlafaxine metabolites, and the ratios of NODDV to NDV were 1.55 and 0.73 for Sand R-venlafaxine, respectively. The highest tissue-specific BCFs of the four enantiomers were all found in the eyes, meriting indepth investigation.

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Assessing Adverse Effects of Legacy and Emerging Contaminants in Fish Using Biomarker Analysis and Histopathology in Active Monitoring Scenarios

Orbea

Bilbao

Cajaraville

2022

Methods in Pharmacology and Toxicology

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Quantifying Bioaccumulation in the Aquatic Environment

Cited by 4 publications

References 41 publications

Bioaccumulation of Per and Polyfluoroalkyl Substances in Antarctic Breeding South Polar Skuas (Catharacta maccormicki) and Their Prey

Bioaccumulation of Per and Polyfluoroalkyl Substances in Antarctic Breeding South Polar Skuas (Catharacta maccormicki) and Their Prey

Enantiospecific Uptake and Depuration Kinetics of Chiral Metoprolol and Venlafaxine in Marine Medaka (Oryzias melastigma): Tissue Distribution and Metabolite Formation

Assessing Adverse Effects of Legacy and Emerging Contaminants in Fish Using Biomarker Analysis and Histopathology in Active Monitoring Scenarios

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